大突变

稳态大注入突变异质结Poisson方程理论

Poisson 's Equation Theory for the Abrupt Heterojunctions Under the Stable Large Injection Condition

目的：研究蛋白质截短技术（PTT）在ATM等大基因突变检测中的可行性。

Objective To study whether protein truncation test ( PTT ) is suitable for mutation detection in large size gene , such as ATM .

水稻种子经卫星搭载后大粒型突变系的分子生物学分析

Molecular Biological Analysis of Large-Grained Rice Mutant Induced by Outer Space Condition

限制酶切指纹-单链构象多态性&一种有效的大片段中突变的检测方法

Restriction endonucleases fingerprinting-single strand conformation polymorphism : an efficient method to screen mutations in long segments

研究指出，45岁以上的男人生出的孩子患自闭症和精神疾病的风险比其他孩子更高。父亲年龄越大，基因突变的概率也会成倍增加。

The finding comes weeks after leading scientists reported children born to men over the age of 45 run a higher risk of having autism and psychiatric disorders .

建立了锤头在冲击过程中任一瞬时变形长度和非变形长度的数学模型，找到了工程应变和冲击速度之间的曲线对于塑性大变形的突变点及影响落锤变形的各个因素和控制变形的依据。

The factors influencing the deformation of hammer have been found out and the strategies for the control of the deformation are discussed . The plastic big deformation mutation point of curve have been found out between engineering strain and impact speed .

大肠癌p53基因突变与血清抗体的相关性研究及意义

Relationships between p53 gene mutation and serum p53 antibodies in colorectal cancer and their clinical significance

BAX基因在遗传不稳定的大肠癌、胃癌突变的研究

Study of the mutation of Bax gene in genetically unstable cancers of the stomach and colorectum

大肠癌组织p53突变率为48%（27/56）。

The mutations of p53 gene were detected in 48 % ( 27 / 56 ) of colorectal carcinomas investigated .

中国人散发性大肠癌K-ras基因突变的研究

K-ras mutation in sporadic colorectal cancer in China

PCR-SSCP银染法快速、简便，特别适用于对大样本基因点突变的检测。

PCR-SSCP silver-staining method is a simple and economic method and is particularly useful in the screening of point mutations in large number of samples .

目的：探寻结直肠癌缺陷基因（DCC基因）201密码子在大肠癌中的突变规律。

Objective : To explore the frequency of codon 201 point mutation of DCC gene in colorectal carcinoma ( CRC ) and the relationship between codon 201 mutation and biologic behavior of CRC .

患者粪便脱落细胞APC基因的突变率为37.75%（16/43），腺瘤和大肠癌APC基因突变分别为25%（2/8）和40%（14/35）。

The mutation rate of epithelial cell shed from intestine in stool was 37.75 % ( 15 / 13 ) . The positive rate of adenomas and CRC were 25 % ( 2 / 8 ) and 40 % ( 14 / 35 ) respectively .

结论：长期低剂量接触贫铀，其方式无论是食入、植入均可对大鼠产生致突变作用。

CONCLUSION : After long-term low-dose exposure , DU can cause mutagenesis effect on rats no matter ingesting or implanted .

重要的是，大鼠肌肉注射突变型集聚蛋白后产生的变化和在患者中观察到的突出前和突触后变化一致。

Importantly , the changes observed in rat muscle injected with mutant agrin recapitulated the pre-and post-synaptic modifications observed in the patient .

大绝灭（即集群绝灭）事件反映了全球环境的大突变，点断了地质历史中的生命记录及其发展历程，预示着生物界的演化出现了最有意义的飞跃。

Mass extinction greatly changed global biotas , punctuated the life records , and played an extraordinary role in the history of evolution .