青霉酸

青霉酸对尼西鸡的毒性作用

Toxicity of Penicillic Acid in Broiler Chickens

为探讨青霉酸最有效的化学脱毒方法，采用碳酸氢钠、次氯酸钠、氢氧化钠和氯化钠等化学脱毒剂对青霉酸进行了去毒试验。

To find out the most effective chemical method in detoxifying penicillic acid , an experiment was conducted by using sodium bicarbonate , sodium hypochlorite , sodium hydroxide and sodium chloride .

用3.00%的碳酸氢钠处理青霉酸只需1d，就能达到理想的去毒效果。

Sodium bicarbonate at 3.00 % level had an ideal effectiveness of detoxification when it was used for only 1 day .

圆弧青霉菌毒素&青霉酸的单克隆抗体及免疫毒理学研究

Studies on the Immune-toxicology of Penicillic Acid from Penicillium Cyclopium and Its Monoclonal Antibody

圆弧青霉菌毒素-青霉酸对小鼠肾脏损伤及损伤机理的研究

Effects on kidney damage and its mechanism induced by a toxin of penicillium cyclopium-penicillic acid

结果表明：①青霉酸中毒尼西鸡的主要病理变化是肝细胞脂肪变性、肾小管上皮细胞浊肿、心肌细胞颗粒变性；

The results showed that : ① major pathological changes was fatty and vacuolar degeneration of hepatocytes , cloudy swelling of renal epithelial cells and myocardial cells ;

用HPLC法测定6-氨基青霉烷酸色谱条件的探索

Developing the Analytical Methods of 6-Amino Penicillanic Acid by HPLC

通过确定苯乙酸、青霉素G在离子交换柱中的动力学行为和固定化酶的动力学参数，利用已建立的数学模型，可很好地对青霉素G水解生产6-氨基青霉烷酸过程进行计算机模拟。

Based on Phenylacetic acid and Penicillin G dynamics in ion exchange process and immobilized enzyme kinetics , the hydrolysis of Penicillin G was simulated well by computer from the mathematical model developed .

研究齐墩果醇酸（oleanolicacid，OA）对6-氨基青霉烷酸APA-蛋白致敏豚鼠过敏休克的对抗作用。

Reduction of histamine contents . To study the antagonistic effect of oleanolic acid ( OA ) on anaphylactic shock in guinea-pigs sensitized with 6-aminopenicillanic acid ( APA ) - protein .

目前PGA主要催化水解青霉素G生成6-氨基青霉烷酸（6-aminopenicillanicacid，6-APA）及苯乙酸，6-APA是工业上半合成β-内酰胺类抗生素的关键中间体[13]。

PGA catalyze the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid-one of the key intermediates for the production of semisynthetic β - lactam antibiotics .

青霉素酰化酶酶活可以利用荧光胺和6-氨基青霉烷酸（6-APA）反应加以测定。

The reaction of 6 - aminopenicillanic acid with fluorescamine can be used to determine penicillin acylase activity .

测定了苯乙酸（PAA）在纯水和水乙醇、水丙醇混合溶剂中的溶解度以及6-氨基青霉烷酸（6-APA）在PAA溶剂中的萃取动力学。

The solubility of phenoxyacetic acid ( PAA ) in water , water-ethanol , water-acetone and the extraction kinetics of 6-aminopenicillanic acid ( 6-APA ) in PAA was measured .

考察了青霉素G，丙酮和苯乙酸（PAA）杂质在6氨基青霉烷酸（6APA）结晶过程中对晶习的影响及其在乙醇溶液中的生长过程。

The effects of impurity of penicillin G , acetone and phenoxyacetic acid ( PAA ) on habit of 6-aminopenicillanic acid ( 6-APA ) in the process of its crystallization and the growth of 6-aminopenicillanic acid in the solution of ethanol are studied .

6-氨基青霉烷酸（6-APA）是生产各种半合成青霉素的原料，在半合成抗生素工业中占据着重要地位。

6-aminopenicillanic acid ( 6-APA ) is a precursor for the synthesis of semi-synthetic penicillins and a critical element in the production of semi-synthetic β - lactam antibiotics .

用静态法研究了6-氨基青霉烷酸在弱碱性阴离子交换树脂IRA67上的吸附行为。

The adsorption behavior of6-aminopenicillanic acid ( 6-APA ) on weak basic anion exchange resin IRA67 was studied .

6-氨基青霉烷酸（6-APA）是半合成β-内酰胺抗生素的关键中间体，年产量在10000吨以上，酶法水解青霉素是生产6-APA的重要途经。

6-aminopenicillanic acid ( 6-APA ) is a key intermediate for production of semi-synthetic β - lactam antibiotics . It is produced industrially at a scale of 10,000 ton / year .

而青霉素酰化酶是一种重要的工业用酶，用来催化青霉素盐去酰化反应，得到制备半合成青霉素的必需中间体6-氨基青霉烷酸（6-APA）。

The two layered materials were used as supports for the immobilization of penicillin G acylase ( PGA ), which is an important enzyme for catalysis of the deacylation of penicillin to afford a necessary intermediate in the manufacture of semisynthetic penicillins .

用固定化细胞裂解苄基青霉素制备6-氨基青霉烷酸

Production of 6 - aminopenicillanic acid from benzylpenicillin by immobilized E.coli cells

青霉烷酸衍生物构效关系的理论计算与研究

Theoretic calculation and study on structure-activity relationship of penicillin derivatives

6-氨基青霉烷酸晶体生长过程中杂质对晶习的影响

Effect of Impurity on the Crystal Habit of 6-aminopenicillanic Acid During Its Growth

乙醇、甲醇对6-氨基青霉烷酸结晶条件的影响

Effect of ETHYL-OR methyl alcohol on the crystallization condition of 6-amino penicillanic acid

过饱和度和温度对6-氨基青霉烷酸生长晶习的影响

Effect of Supersaturation and Temperature on the Crystal Habits of 6 - Aminopenicillanic Acid

6-氨基青霉烷酸衍生物的研究Ⅰ.6-（取代丙烯酰氨）青霉烷酸的合成

Derivatives of 6-aminopenicillanic acid ⅰ . synthesis of 6 - ( substituted acrylamido ) penicillanic acid

本文较详细地研究了乙醇、甲醇对6-氨基青霉烷酸结晶条件的影响。青霉素裂解液中加入一定量的乙醇或甲醇可防止苯乙酸的结晶。

We studied the effect of ethyl - or methyl alcohol on the crystallization condition of 6-Aminopenicillanic Acid in detail .

目的改进β-内酰胺酶抑制剂泰唑巴坦关键中间体2α-甲基-2β[（1,2,3-三唑-1-基）-甲基]青霉烷酸砜二苯甲酯（Ⅰ）的合成。

Objective To modify the synthesis of Benzhydryl 2 α - methyl-2 β - [ ( 1,2,3 - triazol - 1-yl ) - methyl ] penicillanate-1,1-dioxide ( ⅰ ), the key intermediate of β - lactamase inhibitor tazobactam .

马尔尼菲青霉异柠檬酸裂解酶的表达与其酵母相生长的关系

The relationship between expression of isocitrate lyase and development of penicillium marneffei yeast

圆弧青霉毒素&青霉酸对小鼠肝脏损伤的实验研究

Experimental Studies of Injury to the Liver Tissue by Cyclopium Penicillic Toxin-PA

为探讨青霉毒素对动物的毒性作用，给家兔静脉注射圆弧青霉毒素（青霉酸），对其中毒的临床与病理学进行了观察。

The clinical and pathological manifestation were observed after intravenous injection of penicillic acid in rabbits .