赋形剂
- 名excipient;vehicle
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(1) [vehicle]∶一种不发生化学反应的药用混合物(如糖浆、猪油或液态凡士林),其中加入一种具有疗效的药物或者通过它使其他成分胶合在一起
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(2) [excipient]∶构成药物或抗原的辅料的无活性物质(如阿拉伯胶、糖浆、羊毛脂或淀粉);尤指在药物混合物中有足够量液体情况下,为使混合物有粘性,以便制备丸剂或片剂而加入的物质
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结果:预冻溶液最佳pH值为4.0~5.0;所采用的4种赋形剂中,甘露醇效果最优,其最佳用量为10.0%;
Results : The optimal pH value was 4.0 ~ 5.0.10 % mannitol was used as the optimal excipient .
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但是RPM也存在自身毒性作用大,吸收限制、亲水性差,对pH敏感和治疗指数偏低,生物应用受限于赋形剂、稳定性等药理学缺点。
However , RPM also has such pharmacological defects as toxic effect , restricted absorption , poor hydrophilicity , restricted biological application by excipient and stability , sensitivity to pH and low treatment index .
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前列腺素E1冻干静脉注射粉剂及赋形剂研究
A Research of the Aseptic Frozen-Dried Powder of Intravenous Injection of PGE_1 and Its Excipients
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目的:比较0.1%,0.03%他克莫司软膏与赋形剂治疗中、重度特应性皮炎(AD)的疗效和安全性。
Objective : To observe the clinical efficacy and safety of 0.1 % and 0.03 % tacrolimus cream in topical treatment of moderate to severe atopic dermatitis in adults .
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本文描述玻璃体内注射用的TA的配制法并分析赋形剂(苯甲基乙醇)过滤后的实际剂量。
Preparation of TA for intravitreal injection will be described and its actual dosage after filtration of the vehicle ( benzyl alcohol ) be analyzed .
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方法采用常规药敏试验,观察不同赋形剂的氢氧化钙糊剂对白色念珠菌作用48h后的抑菌圈直径。
[ WTHZ ] Methods We observed the diameters of bacterial inhibition zones after Candida albicans with the medicaments incubated for 48 hours .
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用Lowry法测定冻干注射用胸腺肽中多肽含量时,由于冻干前所加赋形剂甘露醇的干扰,其测定结果明显偏高(P<0.0005)。
When the contents of polypeptide in lyophilized thymosin for injection are determined by Lowry method , the result shows that is obviously increased ( p < 0.0005 ) since it is added mannitol before the freeze drying .
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1%贝沙罗汀凝胶与赋形剂凝胶联合窄波UVB光疗治疗中重度寻常型银屑病:一项随机、双盲、赋形剂对照比较试验
A randomized , double-blind , vehicle-controlled , bilateral comparison trial of bexarotene gel 1 % versus vehicle gel in combination with narrowband UVB phototherapy for moderate to severe psoriasis vulgaris
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结果:赋形剂用量为0.02g,浆糊浓度为22%,浆糊用量为40g,湿混合时间为15分钟为最佳生产工艺。
Results : Solid is 0.02g , liquid is 22 % and 40g , time is 15 minutes .
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结论TA玻璃体内注射时,≤25mg的无赋形剂TA对视网膜形态和功能无影响;赋形剂的存在可导致视网膜功能和形态改变。
Conclusion Intravitreous injection of TA with the dosage of ≤ 25 mg without excipient does no harm to the retinal configuration and function , and excipient may lead to the change of retinal configuration and function .
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人们认为这是由于在制药过程中需要的赋形剂引起的而不是TTFD的直接作用。
It is thought that this is due to the excipients in the preparation rather than a direct effect of TTFD .
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但调查中没有发现对FDOPA的毒性研究内容,或临床剂型中杂质和赋形剂的使用量。
The literature survey did not identify any study that examined the toxicity profile of FDOPA or that quantified impurities or excipients potentially present in clinical formulations .
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将儿童特应性皮炎分为2组,分别外用0.03%他克莫司软膏(21例)和赋形剂(21例)。每日2次,疗程为3wk。
Another 42 children with atopic dermatitis were divided into two groups with 21 patients under ( 0.03 % ) tacrolimus ointment and 21 patients for vehicle treatment in the same way for a course of 3 wk .
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应用单因素实验选择使用不同的崩解剂和赋形剂以确保最佳崩解。
Different disintegrants and excipients were decided by single factor test .
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对照组只用赋形剂进行类似的治疗。
A control group was treated similarly with the vehicle only .
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该法简便,样液稳定,赋形剂对测定无干扰。
The method was simple , stable and undisturbed with excipient .
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注射剂的新型赋形剂&胆盐/卵磷脂混合胶束系统
A New Injectable Vehicle & Bile Salt / Phosphatidylcholine Mixed Micelles System
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注射用冻干转移因子赋形剂的初步筛选
Preliminary screening of the excipients of freeze - drying transfer-factor for injection
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结果:使用40%甘露醇作为赋形剂效果较好;
RESULTS : Take the40 % mannitol as excipient ;
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赋形剂用作药物的稀释剂或赋形剂的一种掺入物质。
An inert substance used as a diluent or vehicle for a drug .
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不同赋形剂氢氧化钙抑制白色念珠菌的药敏试验
Antibiotic susceptibility test of calcium hydroxide mixed with different vehicles against Candida albicans
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不同赋形剂及配方对中药喷雾干燥浸膏粉制粒的影响
Effects of different excipients and its compound on extract granulating made by spray drying
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甘露醇是药品冷冻干燥中常用的低温保护剂和赋形剂。
Mannitol is usually used as a cryoprotectant and an excipient during pharmaceutical freeze-drying .
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玉米淀粉作为方便面酱料赋形剂的研究
Study On Using Maize Starch as Forming Agent of Sauce in Instant Noodle Production
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复方番泻叶微丸赋形剂的选择
Selection of excipient on compound folium sennae pellets
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化妆品赋形剂对皮肤的临床效果
Clinical effects of cosmetic vehicles on skin
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目的选择复方番泻叶喷雾干燥粉末微丸成型工艺的赋形剂。
AIM To select excipient of preparation technology of compound folium sennae spray drying powder .
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电镜发现胶囊大、小剂量组的心肌超微结构的损伤明显比赋形剂组轻。
The damage to the myocardial ultrastructure was milder in Xindakang-treatment group than control group .
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某些疫苗使用动物制品(例如明胶)作为赋形剂。
Animal products , for example gelatin , are used as an excipient in some vaccines .
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气相色谱法研究赋形剂对苯唑青霉素钠稳定性的影响
Investigation of the influence of excipients on the stability of sodium oxacillin by pyrolysis gas chromatography