舒林酸

舒林酸对小鼠大肠癌模型p53、Bcl-2和Bax表达的影响

Influence of Sulindac on the Expressions of p53 , bcl-2 and Bax in Mice Model with Colon Carcinoma

舒林酸诱导胃癌BGC-823细胞凋亡的研究

A Study on the Apoptosis of BGC-823 Gastric Cancer Cells Induced by Sulindac

NF-κB途径在舒林酸促人胃癌SGC-7901细胞凋亡中的作用

The role of NF - κ B pathway of sulindac-induced apoptosis in human gastric carcinoma SGC-7901 cells

结果舒林酸、尼美舒利可以抑制人胃癌SGC-7901细胞生长并具有浓度、时间依赖性；

Results Tumor cells proliferation was inhibited in dose and time dependent manner .

舒林酸抑制胃癌BGC-823细胞生长的实验观察

Inhibitory effect of sulindac on the growth of gastric cancer cells in vitro

舒林酸对胃癌细胞株BGC-823作用的实验研究

Experimental study for effect of sulindac for gastric cancer cell BGC - 823

舒林酸在防治小鼠大肠癌中对p53和p21~（WAF1）影响的初步研究

Initial Research For Influence On P53 And p21 ~ ( WAF1 ) By Sulindac During Protecting From Colon Carcinoma in Mice

PPARγ通路在舒林酸抑制胃癌细胞增殖中的作用及机制

A study of the effects of PPAR γ pathway on the proliferation inhibition of gastric cancer cells by sulindac and the underlying mechanism

目的观察舒林酸对家族性腺瘤息肉病（FAP）的临床疗效，并探讨其可能的作用机制。

Objective To assess the clinical efficacy of sulindac on familial adenomatous polyposis ( FAP ) and its possible mechanism .

结论舒林酸的硫化代谢产物能够显著抑制血管内皮细胞的增殖活性，改变细胞的周期分布，使细胞阻滞于G2期，并可能在此期诱导其凋亡。

Conclusions Sulfide can significantly reduce the proliferation of ECV304 , change the cell cycle distribution and arrest cells in G2-M phase where apoptosis may be induced .

结论系统评价结果显示舒林酸对于家族性FAP的疗效尚不确切，而对SCAP有一定的疗效。

Conclusion The therapeutic effect of sulindac on FAP is not sure , but it is effective on SCAP .

结论舒林酸、尼美舒利可以抑制人胃癌SGC-7901细胞增殖，抑制NF-κB，COX-2的蛋白表达在二者抑制肿瘤机制中可能具有一定作用。

Conclusion The proliferation of SGC-7901 cells was inhibited after treated by sulindac and nimesulide . Suppressing COX-2 , NF - κ B expression may play some roles in the antitumor process of these two drugs .

方法对人胃癌SGC-7901细胞采用细胞培养，MTT法检测不同浓度舒林酸、尼美舒利对人胃癌SGC-7901细胞增殖抑制作用，免疫组化、westernblot方法检测药物对COX-2、NF-κB表达的影响。

Methods SGC-7901 cells were treated by sulindac and nimesulide . The anti-proliferative effect was measured by using MTT assay ; COX-2 and NF - κ B protein expression were examined by immunohistochemical stain and western-blot analysis .

背景与目的：体外研究舒林酸对人胃癌bgc-823细胞的生长抑制作用，探讨其作用机制。

Background & aim : to study the effect of Sulindac on growth inhibition of human gastric cancer cells bgc_823 in vitro and its antineoplastic mechanisms .

结论舒林酸长期维持治疗可使FAP患者结直肠腺瘤保持长期显著消退状态。

No severe adverse event was found during the treatment . Conclusions Long-term treatment of sulindac is effective in maintaining the regression of colorectal adenoma in FAP patients .

结论：舒林酸可抑制结肠癌细胞株HT-29生长，其机制可能与其阻止细胞周期的进展，诱导细胞凋亡有关。

Conclusions : Sulindac may inhibit the proliferation and induce apoptosis of colon cancer cell HT-29 , and its mechanism probably relates to the progress of its prevention on cell cycle .

口服舒林酸胶囊剂和片剂的相对生物利用度

ABSTRACTS OF ORIGINAL ARTICLE Relative bioavailability of sulindac capsules

舒林酸对卵巢癌裸鼠腹腔移植瘤生长的影响

Effect of sulindac on growth of transplantable ovarian carcinoma of nude mice model

舒林酸食道支架放疗联合治疗食道癌48例分析

Analysis of 48 cases of esophageal cancer treated by sulindac stents combined radiotherapy

目的评价舒林酸治疗结直肠息肉的有效性和安全性。

Objective To assess the efficacy and safety of sulindac on colorectal polyps .

舒林酸抑制人胃腺癌细胞增殖及诱导凋亡

Effects of Sulindac on growth inhibition and apoptosis induction in human gastric cancer cells

目的：观察新型非类固醇类抗炎药&舒林酸对实验性高钙尿症的防治作用，探讨其可能机制。

OBJECTIVE To observe the therapeutic effects of sulindac ( a new type of NSAIDs ) on experimental hypercalciuria and to clarify its pharmacological mechanism .

目的：本实验通过观察舒林酸对凋亡调控基因的影响，初步探讨舒林酸防治肿瘤作用可能存在的分子机制。

Objective : To observe the effect of Sulindac on changes of the apoptosis regulating genes in different stages of the tumor formation , and probe the possible anticarcinogenic molecular mechanism of sulindac .

它对肾脏及胃肠道的不良反应均小于其它传统的非甾体抗炎药。近年来，有很多研究证实舒林酸同时具有降低结直肠肿瘤及家族性结肠息肉的作用。

In recent years , Accumulating evidences have indicated that sulindac appears to reduce the risk of colorectal cancer , decrease the incidence of familial adenomatous polyposis . Compared with other traditional nonsteroidal anti-inflammatory drugs , sulindac has less adverse reactions .

舒林酸是吲哚乙酸类非甾体抗炎药，主要用于治疗类风湿性关节炎、强直性脊椎炎、骨关节炎、急性痛风及肩关节疼痛等。

Sulindac is a nonsteroidal antiinflammatory drug ( NSAID ) of the indene acetic acid class . Sulindac can be used to treat rheumatoid arthritis , osteoarthritis and ankylosing spondylitis , Other uses include the treatment of acute gouty arthritis and acute painful shoulder .