萘普生

pH对萘普生透皮速率的影响

Effect of pH on percutaneous absorption of naproxen

萘普生和萘普生乙酯在环糊精手性柱上的HPLC分析

HPLC Analysis of Naproxen and Its Ethyl Ester on β CD Chiral Column

手性流动相HPLC法拆分萘普生对映体的研究

Study on resolution of racemic naproxen with chiral additive as mobile phase by RP-HPLC

萘普生稀土（Ce、Gd）配合物的合成及稳定性研究

Study on the Synthesis and Stability of Rare Earth ( Ce , Gd ) Naproxen Complexes

经统计学分析表明，两者无显著性差异（P＞0.05）。结论：贝氏萘普生片对联邦萘普生片的相对生物利用度为（102.72±13.76）%，两种萘普生片具有生物等效性。

Conclusion : The relative bioavailability of NAPB tablets was ( 102.72 ± 13.76 ) % compared with NAPL tablets . The result of the statistical analysis showed that the two formations were bioequivalent .

CSTR和批式反应器中酶法拆分萘普生的比较

Comparison between Enzymatic Kinetic Resolution of Naproxen in Batch Reactor and CSTR

采用高效液相色谱在纤维素三醋酸酯（CTA）手性柱上，对7种结构不同的外消旋萘普生酯进行了手性拆分。

Chiral resolution of seven racemic naproxen esters was performed on CTA chiral stationary phase .

我们也使用S-萘普生和S-酮洛芬作为模板分子制备了MIP毛细管涂层柱。

The MIP coatings were also prepared using either S-naproxen or S-ketoprofen as template molecule .

以S萘普生为模板，N乙烯基吡咯烷酮为功能单体，二乙烯基苯为交联剂分别按照摩尔比1/4/10、1/4/20和1/4/30合成了分子印迹聚合物（MIP）。

Molecularly imprinted polymers were prepared using S-naproxen as a template molecule , N-vinylpyrrolidone as a functional monomer and divinylbenzene as a crosslinker .

实验结果表明：外消旋萘普生酯能在CTA手性柱上获得分离；

Results showed that racemic mixtures of naproxen ester could be separated on CTA chiral stationary phase .

结果：萘普生的稳态透皮速率随pH升高而增大，而表现渗透系数则随pH升高而减少。

RESULTS : When the pH in the donor compartment of the diffusion cell was increased the steady state flux of naproxen was increased , on the contrary , the apparent permeability coefficient was decreased .

方法123例患者随机分成试验组和对照组，试验组服用盐酸文拉法辛胶囊25mg，bid，对照组服用萘普生片0.2g，bid，服药疗程均为14d。

METHODS 123 tension-type headache patients were randomly assigned to Venlafaxine 25 mg group , or Naproxen 0.2 g group as control .

结果：尼美舒利的总有效率为83%，萘普生的总有效率为75%（P＜0.05）。不良反应发生率分别为23%和32%（P＞0.05），以胃肠反应为主。

RESULTS : Both nimesulide and naproxen improved the inflammatory signs and symptoms of patients with to_ tal effective rates 83 % and 75 % respectively ( P 0.05 ) and adverse reaction rates of 23 % and 32 % respectively ( P0.05 ) .

并通过商品脂肪酶（Candidarugosalipase）及芽孢杆菌E-53脂肪酶催化的萘普生甲酯的不对称水解反应得到了证实。

They were experimentally verified by the commercial preparation lipase ( Candida rugosa ) and Bacillus E 53 lipase catalyzed asymmetric hydrolysis of racemic naproxen methyl ester .

结果：服用萘普生组30日内为症状消失100%，而对照组为87.5%，两组对比有显著性差异（P0.01）；

Results : Taking the Naproxen Tablets Tablets is 100 % on 30 inside the set , but is 87.5 % on 30 inside the matched control , two contrasts contain obvious difference ;

萘普生对大鼠着床期宫内PGF（2α）含量及宫内节育器抗生育作用的影响

Influence of Naproxen on the Content of Uterine PGF_ ( 2 α) in Implantation Period and Antifertility Effect of IUDs in Rats

结果表明：与PVP、PAA均聚物和物理混合物相比，PAA/PVP复合物作为药物载体能使萘普生具有肠溶包衣片的性质；

It shows that , compared with PVP , PAA homopolymers and physical mixtures , the complexes of PVP and PAA as drug carriers make naproxen have the property of enteric-coated pellets .

如果可能，GERD病人应避免非甾体类抗炎药，如阿司匹林、布洛芬或萘普生。

If possible , GERD patients should avoid nonsteroidal anti-inflammatory drugs ( NSAIDs ), such as aspirin , ibuprofen ( Motrin , Advil ), or naproxen ( Aleve ) .

进行了XDA型吸附树脂对萘普生和二氯氟苯生产废水的吸附处理研究。

The treatment of wastewater containing 2-methoxy 6-propionyl naphthalene and 2,4 dichloro fluorobenzene with adsorption resin was studied .

基于环氧合酶-2（COX-2）与COX-1结构上的差异，设计了萘普生的噻唑衍生物，以期利用COX-2的侧面口袋，增加对COX-2的结合作用。

Based on the differences between cyclooxygenase-2 ( COX-2 ) and COX-1 , a series of derivatives of naproxen in which the carboxyl group was replaced with a variety of substituted thiazolyls were designed .

为手性固定相时，利用高效液相色谱法考察了流动相组成、pH值、温度对萘普生和布洛芬对映体拆分的影响。在温度274～313K的实验范围内，R-体先被洗脱；

In the range of temperature 274 to 313 K , the R-enantiomer is eluted firstly , and the capacity factor , selectivity and resolution of enantiomers decrease as temperature increases .

根据萘普生在碱性介质中的内源荧光，提出用直接荧光法测定萘普生胶囊的含量，线性范围为0.2～14.0μg·mL~－1。

According to the fluorescence of naproxen in basic solution , a quantitative determination of naproxen in the naproxen capsules has been established . The method is very simple and sensitive . The linear range is between 0.2 ~ 14.0 μ g · mL ~ - 1 .

方法采用硬脂酸包裹和羟丙甲基纤维素（HPMC）水凝胶缓释技术及UV测定法，研究了萘普生骨架型缓释颗粒胶囊并进行初步稳定性试验。

METHODS : The stearic acid coating , hydroxypropyl methylcellulose ( HPMC ) hydrogel sustained-release and ultraviolet measurement technology were undertaken to study the naproxen matrix sustained-release granular capsule and an initial stability test was also done .

水中PPCPs萘普生的光催化降解及降解后水溶液的毒性评价

Degradation of Drug Naproxen in Aqueous Medias by Photocatalysis and The Evaluation of Toxicity Generated by Intermediates

涉及到的药物有生物碱、中草药有效成分、四环素类、喹喏酮类、维生素B2、抗癌药物、萘唑啉、萘普生和血管扩张剂潘生丁双嘧哌胺醇等。

The drugs involved here included the varieties of alkaloid , Chinese traditional medicine , tetracyclines , quinolone , riboflavin , anticancer medicine , naphazoline , naproxen , nafronyl dipyridamole and so on .

本文测定了对照组及两个萘普生（前列腺素合成酶抑制剂）处理组大鼠着床期宫内PGF2α的含量。

The levels of PGF2 α in uterine tissues of naproxen-treated and control rats in implantation period were measured and compared .

以S-萘普生为模板，分别采用丙烯酰胺（AM）、N-乙烯基吡咯烷酮（NVP）和甲基丙烯酸（MAA）3种功能单体，合成了印迹聚合物P1、P2和P3。

Using S-naproxen as template , molecularly imprinted polymers P1 , P2 and P3 were synthesized by different functional monomers , acrylamide ( AM ), methacrylic acid ( MAA ) and N-vinylpyrrolidone ( NVP ) respectively .

通过萘普生及其包合物的13C-NMR谱表明甲氧基端碳受到的屏蔽效应更大，可能已经进入到β-环糊精的腔内。

Naproxen and its inclusion compound by 13C-NMR spectra showed that the methoxy carbon by the end of the shielding effect of a larger , may have entered into the β - cyclodextrin cavity .

支配手性拆分的主要因素是外消旋萘普生酯在CTA手性空腔中的体积大小适应性，尤其是立体结构的空间适应性是关键。

The decisive factor for the chiral recognition is the fitness of the size of racemic naproxen ester to the chiral cavities of CTA , however the space fitness of the steric structure of the solute is also a key point .

Farkouh及其同事调查了患有关节炎的高危患者应用布洛芬、萘普生或氯美昔布治疗的心血管结果。

Farkouh and associates investigated cardiovascular outcomes in high-risk patients with arthritis treated with ibuprofen , naproxen , or lumiracoxib .