肝衰竭

结果医院感染疾病，原发性细菌性腹膜炎居首，败血症其次，深部真菌感染发生率17%，肝衰竭患者中发生率占32%，病死率高达82.1%；

RESULTS Among nosocomial infection diseases , the first was peritonitis , the next was septicemia . Morbidity of systemic fungal infection was 17 % > hepatic failure was 32 % , and its mortality was 82 . 1 % .

组织蛋白酶B在小鼠暴发性肝衰竭肝组织中的表达

Expression of cathepsin B in liver tissue of fulminant hepatic failure in mice

乌司他丁对Wistar大鼠暴发性肝衰竭的治疗作用

The therapeutical effect of Ulinastatin on fulminant hepatic failure in Wistar rat

[实验结果]1、NK细胞在病毒诱导的急性肝衰竭肝损伤中发挥重要作用。

NK cells play a significant role in virus induced acute liver injury .

辨证论治肝衰竭疗效的Meta分析

Dialectical Liver Failure on the Treatment of Meta-analysis of Efficacy

实验性暴发性肝衰竭大鼠肝脏NK细胞与肝再生的关系

Relationship Between Liver Resident NK Cells and Liver Regeneration in Experimental Fulminant Hepatic Failure

慢性乙肝患者与肝衰竭患者准种条带间比较差异有统计学意义（P＜0.05），肝衰竭患者血清内HBV-DNA基因S区的准种复杂度高于慢性乙肝的患者。

There is statistical meaning ( P0.05 ) in comparative difference among quasispecies stripes of the patients with CHB and Patients with liver failure .

结论（1）D-gal1.4g/kg腹腔注射可以很好构建SD大鼠急性肝衰竭模型。

Conclusion ( 1 ) Acute hepatic failure of rats can be induced with D-gal at the dose of 1.4g/kg very well .

PDTC对暴发性肝衰竭大鼠肝组织NF-κB及其调控炎症细胞因子的影响

Effect of PDTC on NF - κ B and the Inflammatory Cytokines in Liver Tissue of Experimental Fulminant Hepatic Failure

急性肝衰竭大鼠肝组织iNOS和VEGF的表达及氨基胍的干预作用

The Expression of iNOS and VEGF in Liver Tissue of Rats with Acute Liver Failure and the Effect of Aminoguanidine

肝性脑病（hepaticencephalopathy，HE）是肝衰竭的一种严重并发症，其死亡率极高，严重危害人类的健康。

The hepatic encephalopathy ( HE ) is a serious complication of liver failure with a high mortality and serious harm to human health .

PAF水平对肝衰竭患者HRS的发生可能有一定预测作用。

The PAF level may forecast whether patients with liver failure will take place HRS .

方法24例肝衰竭合并MODS患者进行了60次6～24h的MARS治疗。

Methods 60 single MARS treatments were performed for 6-24 hours on 24 severe liver failure patients with MODS .

方法以D-氨基半乳糖胺（D-gal）作为肝脏毒剂，构建雌性SD大鼠急性肝衰竭模型。

Methods A female rat model of liver injury induced by D-galactosamine ( D-gal ) was established .

本实验结果显示对乙酰氨基酚、D-氨基半乳糖联合内毒素诱导的急性肝衰竭时HIF-1α表达增加。

Our results demonstrated that HIF-1 α expression increased during APAP or D-GalN / LPS induced acute liver failure .

PGE1治疗对肝衰竭患者生存及并发症发生率影响的荟萃分析

A meta-analysis of PGE_1 Therapy for Survival and Incidence of Complications in Patients with Liver Failure

慢性HBV感染常常会导致肝硬化、肝衰竭以及肝细胞癌的发生，严重威胁着人类的健康。

Chronic HBV infection often leads to the development of liver cirrhosis , liver failure , and hepatocellular carcinoma , which is seriously threatening the human health .

急性肝衰竭（acuteliverfailure，ALF）是病毒性肝炎一种危重的临床综合征，传统支持治疗病死率高达80%。

Acute liver failure ( ALF ) is a devastating clinical syndrome of viral hepatitis , with the mortality rate more than 80 % when treated by traditional supportive therapy .

HBV感染是急慢性肝炎的主要病因，后者可导致终不期肝衰竭甚至肝细胞癌。

Hepatitis B virus ( HBV ) infection is a major cause of acute and chronic hepatitis . The latter can lead to end-stage liver failure and hepatocellular carcinoma .

乙型肝炎病毒感染慢加急性肝衰竭患者PD-1的表达研究

Expression of the Programmed Death-1 in HBV-associated Acute-on-chronic Liver Failure

经生存分析统计，慢加急性（亚急性）肝衰竭试验组的生存率高于对照组（P＜0.05），慢性肝衰竭生存率比较两组间差异无统计学意义（P＞0.05）。

Survival analysis shows that the survival rate in the experimental group is higher than the control group ( P0.05 ) in patients with acute on chronic liver failure , but there is no difference in chronic liver failure ( P0.05 ) .

TLR4在急性肝衰竭模型大鼠中的动态变化及意义

Dynamic changes and significance of Toll-like receptor 4 in the rat model of acute liver failure

而随着用药时间的延长，HBV可能会发生NA相关的耐药突变，从而可导致肝炎发作，甚至肝衰竭和死亡，因而NA相关HBV耐药突变是一重要的临床问题。

Mutations associated with NA-resistant may develop with prolonged theatment , which can lead to hepatitis attack , even liver failure and death . Thus NA-resistant mutation is an important clinical question .

结果44例肝衰竭患者，经ALSS治疗后临床症状及体征明显改善；

Results ALSS therapy achieved a remarkable improvement in clinical symptoms and physical signs .

结论：Ch量化值是比TB、Che、PTA更有价值的标志肝衰竭严重程度的实验参数，是判断慢性肝衰竭预后和了解是否有紧急肝移植指征的可靠指标。

Conclusions : The quantitative estimation of Ch value is the most useful parameter to determine the degree of hepatic failure and necessity for urgent liver transplantation .

目的研究小鼠暴发性肝衰竭（FHF）动物模型凋亡肝细胞中凋亡基因胱门蛋白酶（caspase3）mRNA及蛋白的表达及意义。

Objective To study the expression of protein and mRNA of caspase-3 during hepatocyte apoptosis in the mice with fulminant hepatic failure ( FHF ) .

结论：微囊化猪肝细胞腹腔内移植可以提高药物诱导急性肝衰竭大鼠的存活率，改善ALF大鼠的肝功能。

Conclusions : After microencapsulated pig hepatocytes transplantation , the survival rate of ALF rats induced by D-gal increased .

方法：采用ISI1.11,1.76和2.05的三种凝血活酶对52例肝衰竭病人和50例口服华法令的换瓣术后的病人进行PT测定。患者年龄13～76岁。

PTs were measured with three thromboplastin reagents of different sensitivities ( ISI 1.11 , 1.76 and 2.05 ) in plasma from 52 patients with liver failure and 50 patients with oral anticoagulation .

目前，对于BMSC治疗肝衰竭作用机制的研究主要集中在BMSC的分化潜能方面。

The study on the mechanism of BMSC transplantation for acute liver failure focused on the potential differentiation ability of stem cell .

目前研究表明慢加急肝衰竭发病机制可能与HBV病毒复制、宿主免疫反应以及感染等多种因素有关，但确切机制尚待进一步研究。

Present study shows that the pathogenesis of acute on chronic liver failure include HBV viral replication , host immune reactions , infection and other factors , but the exact mechanism remains to be further studied .