基因缺陷

这些微观的能量组拥有不同于细胞核中主基因组的自身的DNA，线粒体基因缺陷可能导致从肌肉无力、心衰竭到脑部疾病等多种疾病。

These microscopic power packs have their own DNA , separate from the main genome in the cellular nucleus , and genetic defects can cause a wide range of medical problems from muscle weakness to heart failure and brain disease .

该技术在纠正基因缺陷及基因优化方面有带来革命性改变的潜力。

Its potential to correct genetic defects and introduce enhancements could be transformative .

载脂蛋白E基因缺陷（C57BL/6J-ApoE）小鼠血脂及病理组织学观察

Observations of Serum lipid and Histopathological Status in ApoE Gene Knockout Mice

X染色体异常及其基因缺陷在卵巢早衰发病机制中的研究

The abnormality and genetic disorders of X chromosome involved in premature ovarian failure

X基因缺陷的乙肝病毒基因治疗载体质粒的构建

Construction of X-gene Defected Hepatitis B Virus Vector Plasmid for Liver Cells Gene Therapy

溶血卵磷脂对载脂蛋白E基因缺陷小鼠腹腔巨噬细胞源泡沫细胞胆固醇外流的影响

Effects of Lysophosphatidylcholine on Cholesterol Efflux from Apolipoprotein E Gene Deficient Mouse Peritoneal Macrophage-Drived Foam Cells

的研究何首乌总甙对载脂蛋白E基因缺陷小鼠实验性动脉粥样硬化病变形成的保护作用。

Aim To study the protecting effect of Polygoni Multiflori total glycosides ( PMTG ) on the atherosclerotic lesion formation .

主要观察指标：载脂蛋白E基因缺陷小鼠和正常小鼠小鼠氧化低密度脂蛋白的水平和动脉粥样斑块面积。

MAIN OUTCOME MEASURES : ox-LDL level and atherosclerotic plaque area in mice with Apo-E genetic defect or normal mice .

载脂蛋白E基因缺陷对小鼠主动脉壁caveolin-1表达的影响

Affection of ApoE Gene-deficiency on the Expression of Caveolin-1 in the Wall of Artery

目的：观察丹酚酸B对载脂蛋白E基因缺陷小鼠（ApoE-/-小鼠）动脉粥样硬化（AS）的干预作用。

Objective : To observe the effect of Salvianolic acid B on atherosclerosis ( AS ) of apolipoprotein E-knockout ( ApoE - / - ) Mice .

花色苷对ApoE基因缺陷小鼠炎症信号转导的影响

Effect of anthocyanins on inflammatory signal transduction in ApoE knock-out mice

叶酸、B族维生素缺乏、基因缺陷和关键酶缺失等可导致血浆Hcy水平升高。

Deficiency of folate , vitamin B12 , metabolic gene and key enzyme can result in dis-equilibrium of Hey in EH .

《柳叶刀》上发表的研究治疗的脉络膜缺失症是由X染色体的单一基因缺陷引起的，主要患者为男孩。

The ailment treated in the Lancet study , choroideremia , is caused by defects in a single gene on the X chromosome and mainly affects boys .

发现部分子痫前期患者可能存在HLAG基因缺陷，且HLAG多态性在子痫前期及正常妊娠者中分布也不同。

It is found that some patients with pre-eclampsia maybe have HLA-G gene defect , and the distribution of HLA-G polymorphism was also different .

ApoE基因缺陷鼠免疫、血液稳态和抗氧化功能改变

Changes of immune , haemostasis and anti-oxidation functions in ApoE gene deficiency mice

以载脂蛋白E基因缺陷小鼠腹腔巨噬细胞源泡沫细胞为研究对象，观察溶血卵磷脂对泡沫细胞胆固醇外流的影响以及初步探讨其机制。

Aim To explore the effects of lysophosphatidylcholine ( LPC ) on cholesterol efflux from apolipoprotein E ( apo E ) gene deficient mouse peritoneal macrophage foam cells .

RNAi在基因缺陷模型方面的应用

Application of RNAi in Gene-deficient Models

肝X受体激动剂对高脂载脂蛋白E基因缺陷小鼠动脉壁一氧化氮合酶、增殖细胞核抗原和纤溶酶原激活物抑制剂1表达的影响

The Effects of Liver X Receptor Agonists on the Expressions of Nitric Oxide Synthase , Proliferating Cell Nuclear Antigen and Plasminogen Activator Inhibitor-1 in the Artery of Apolipoprotein E-Deficient Mice

有氧运动和膳食脂肪对ApoE基因缺陷小鼠动脉粥样硬化斑块形成的影响

Effect of Aerobic Exercise and Dietary Fat on the Formation of Atherosclerotic Plaque in ApoE-Deficient Mice

黑米花色苷提取物对ApoE基因缺陷小鼠动脉粥样硬化晚期斑块的影响

Effects of Black Rice Anthocyanin - rich Extract on Advanced Atherosclerotic Plaque in ApoE Deficient Mice

DNA错配修复基因缺陷的MSI-H大肠癌频发Ki-ras基因点突变

Frequent Ki-ras Mutation in MSI-H Colorectal Cancer Deficient in DNA Mismatch Repair Genes

这些建议因基因缺陷而有所不同，例如，在FAP中；

The recommendations differ depending on the genetic defect , for example in FAP ;

阿托伐他汀对ApoE基因缺陷小鼠心肌肥厚一级预防的实验研究

Primary prevention effect of atorvastatin on myocardial hypertrophy in ApoE-deficient ( ApoE - / - ) mice

人类因子IX基因缺陷的研究

Study on gene defects of human factor IX

目的探讨葛根总黄酮对载脂蛋白E基因缺陷小鼠主动脉窦动脉粥样硬化斑块形成的影响。

Aim To investigate the effect of total flavone of radix puerariae on atherosclerotic plaque formation of aortic sinus in apolipoprotein E gene deficient ( ApoE ~ ( - / - )) mice .

进一步研究显示，MBL基因缺陷在感染性和自身免疫性疾病中发挥作用。

MBL deficiency is believed to play an important role in infectious and autoimmune disease .

有氧运动结合低脂膳食组中ApoE基因缺陷小鼠的动脉粥样硬化斑块面积进展低于单独的运动组和低脂膳食组。

ApoE-deficient mice in low fat diet + exercise group have the least lesion area comparing with other groups .

凝血因子Ⅷ（FⅧ）是血液凝固过程中起重要作用的一种血浆蛋白，其基因缺陷可导致临床上常见的遗传性出血性疾病&血友病A。

Human factor ⅷ ( F ⅷ) is a plasma protein which plays a central role in normal blood coagulation . Hemophilia A is caused by a dysfunction of the F ⅷ gene .

质粒pBR322在recA基因缺陷的大肠杆菌细胞内的遗传重组

Genetic Recombination of Plasmid pBR322 DNA in Two recA-Escherichia coli Strains

脂蛋白脂酶（LPL）是脂代谢的关键酶，其基因缺陷与内源性高甘油三脂血症（HTG）及冠心病等多种疾病有密切关系。

The defect of LpL gene is often associated with endogenous hypertriglyceridemia and coronary heart disease .