避孕疫苗

壳聚糖/卵透明带DNA口服避孕疫苗的研究

The Study on Chitosan / zona Pellucida DNA Oral Contraceptive Vaccine

卵透明带DNA避孕疫苗的研究

The Study of Zona Pellucida DNA Contraceptive Vaccine

hCGβ避孕疫苗研究进展

Progress in Research of hCG β Contraceptive Vaccine

HCG避孕疫苗：β-亚单位免疫原的分子修饰和重建

Human Chorinic Gonadotropin Contraceptive Vaccine : Molecular modification and reconstruction of hCG β - subunit immunogen for practice use

为探讨人绒毛膜促性腺激素β亚基（hCGβ）基因避孕疫苗的可能性。

Human chorionic gonadotropin beta subunit ( hCG β) has been considered as a promising candidate antigen for contraceptive vaccine .

以后还需在疫苗剂型上深入研究以增强表位肽的免疫原性而降低甚至避免副作用。本研究为B细胞表位肽疫苗和多价避孕疫苗的研究提供了实验基础。

How to enhance the immunogenicity of B cell epitope but alleviate or avoid side effects should be investigated further . But our study provided experimental ground - work for development of multivalent contraceptive vaccine .

目的：构建猪卵透明带ZP3α真核表达载体，为探讨卵透明带DNA疫苗避孕疫苗奠定基础。

Objective : Constructing the porcine zona pellucida - 3 α eukaryotic expression vector to develop the zona pellucida contraceptive DNA vaccines .

LDH-C4的精子特异性及其良好的免疫原性使其成为一个很好的避孕疫苗候选对象。

Therefore , LDH-C4 is a known candidate antigen for a contraceptive vaccine .

探索卵泡刺激素受体（FSHR）作为男性免疫避孕疫苗的可能性。

E : Study on the possibility of follicle stimulating hormone receptor ( FSHR ) serving as male contraceptive vaccine .

筛选鉴定这些交叉抗原对阐述UU致男性不育机理以及研制避孕疫苗具有重要意义。

It is of great significance to determine these cross-reactive antigens for the benefit of discovering the pathological mechanism of the male infertility caused by UU and designing contraception vaccines .

结论：CTP多聚体能刺激家兔产生特异性抗体，这提示CTP多聚体有可能作为避孕疫苗或肿瘤疫苗的免疫原。

Conclusion : CTP polymeride can stimulate the rabbits to produce the specific antibodies , which suggested the possibility of CTP polymeride as the immunogen for anti-hCG contraception vaccine or cancer vaccine .

目的：为发展避孕疫苗研究制备去糖基猪卵透明带抗原DGZPB和DGZPC并研究它们的免疫反应性。

Aim : To prepare chemically deglycosylated porcine zona pellucida antigens DGZPB and DGZPC from porcine ovaries and characterize their immuno-reactivity for of developing contraceptive vaccine .

人类绒毛膜促性腺激素避孕疫苗的毒理学和免疫安全性研究

Toxicology and safety studies of human chorionic gonadotropin ( hcg ) contraceptive vaccine on rhesus monkey

男性避孕疫苗的研究进展

Advances in Male Contraceptive Vaccine

人们从精子、卵细胞和生殖激素中筛选出最为适合的靶抗原用于免疫避孕疫苗。

Several suitable target antigens from Spermatozoa , ovum and reproductive hormones have been used for the vaccine .

卵透明带是发展孕前型避孕疫苗的一个理想的靶抗原。

Zona pellucida ( ZP ) is a potential target antigen which is used to develop a progestational contraceptive vaccine .

目的探索有效提高避孕疫苗生殖道粘膜免疫的方法。

Objective To explore the methods for the improvement of the effect of genital mucosal immunologic reaction of the contraceptive vaccine .

避孕疫苗根据其作用的靶点不同，分为靶向配子的产生、配子的功能和配子的结局三类。

Based on various targets , the CVs fall into three categories : vaccines inhibiting gamete production , gamete function and gamete outcome .

利用精子抗原来制作避孕疫苗，已成为免疫避孕的研究热点。

Many special sperm antigens have been utilized to prepare contraception vaccine for controlling fertilization , which is focused in immunological contraception research .

国产第一代β-hCG避孕疫苗免疫恒河猴的抗体反应及免疫安全性研究

Antibody Response and Safety Studies on Rhesus Monkey Immunized with the First Generation of Chinese-made Human Chorionic Gonadotropin ( hCG ) Contraceptive Vaccine

以精子／睾丸抗原为靶抗原的免疫性避孕疫苗因可能适用于两性，一直受到研究者的青睐。

In recent years , the researches indicate that the development of a vaccine based on sperm antigens represent a promising approach for contraception .

然而迄今为止没有理想的避孕疫苗问世，究其原因最大的可能在于没有理想的靶抗原。

Up to now , there has been no indication of an ideal contraceptive vaccine being developed probably due to the lack of an ideal target antigen .

文章总结了近年来男性避孕疫苗研究方面所取得的成绩和存在的问题，为进一步开展避孕疫苗的研究工作奠定了基础。

This paper summarizes the achievement and the problems in researching of male contraceptive vaccine , so as to provide a foundation for future research of male contraception vaccine .

结论抗35肽抗体可抑制人精子受精功能，35肽作为一种避孕疫苗有一定开发前景。

Conclusion The anti-35 peptide antibody could inhibit the fertilization ability of human sperms . However , further studies should be conducted for the development of 35 peptide as a new contraceptive vaccine .

本文综述了近年来陆续发现的6种重要的抗精子抗体靶抗原的结构和功能，为进一步探讨抗精子抗体与不育的因果关系以及筛选免疫避孕疫苗奠定基础。

This paper summarizes the structure and function of the six target antigens of antisperm antibodies found recently , so as to discover the causal relationship of the antibodies to infertility and provide a basis for screening a vaccine for immunological contraception .

结论：通过定点突变产生人源化猪ZP4B细胞表位是可行的。研究将为人类克隆并制备新的人卵透明带避孕疫苗奠定基础。

Conclusion : Through humanized point mutation on porcine zona pellucida ( pZP4 ), it 's possible to find a novel way towards the development of a new B-cell epitope of ZP contraceptive vaccines which is of strong immunogenicity as well as potent antifertility effect .

由此可知，豚鼠PH-20免疫豚鼠可得到明显、持久但又可逆的抗生育效应。PH-20在精子表面的分布及其在受精过程中的作用，使其作为免疫避孕候选疫苗一直受到人们的关注。

So we can see that long-lasting and reversible contraception was obtained in male and female guinea pigs immunized with PH-20 . PH-20 is an important candidate for contraceptive vaccine .