过硝酸

结论由过硝酸根介导的自由基氧化损伤在散发性肌萎缩侧索硬化的发病机制中具有重要作用。

Conclusion Free radicals oxidative damage mediated by peroxynitrite plays an important role in the SALS pathogenesis .

过亚硝酸根对DNA的损伤主要有两种形式：DNA碱基修饰与DNA单链断裂。

Two forms of DNA damage caused by peroxynitrite are DNA base modification and DNA single strand breakage .

表明过亚硝酸根在生理pH下分解时有羟自由基产生。

The results indicated that the decomposition of peroxynitrite at physiological pH produces free hydroxyl radical .

即与还原剂Vc协同后，钴盐或钴卟啉可以起到过亚硝酸根清除剂的作用，保护酪氨酸等生物分子不被过亚硝酸根硝化。

Therefore , when coupled with Vc , cobalt salts and cobalt porphyrins served as peroxynitrite scavengers to protect tyrosine and other biomolecules from the nitration induced by peroxynitrite .

与Vc协同后，钴盐或钴卟啉抑制硝化产物的生成，且钴盐或钴卟啉催化过亚硝酸根分解的能力增强。

Cobalt salts or cobalt porphyrins inhibited the nitration of tyrosine in the presence of Vc , and the catalytic activities of cobalt compounds for peroxynitrite decomposition were enhanced sharply .

过亚硝酸根（ONOO-）在生物体内可由多种途径生成，性质活泼，损伤氨基酸、蛋白质、DNA和脂质等生物分子。

Peroxynitrite ( ONOO - ) is an active molecule , which can be formed through multiple pathways in vivo . ONOO - can modify amino acids , proteins , DNA , lipids and other biological molecules in vivo and result in serious biological consequences .

钴盐与过亚硝酸根反应后产物的光谱图说明钴盐影响过亚硝酸根的反应是通过形成Co（III）OONO中间体进行的。

Through the analysis of the products after cobalt salts reacting with peroxynitrite , it was concluded that cobalt salts influenced the reactions of peroxynitrite through Co ( III ) OONO intermediates .

通过过亚硝酸根分解的动力学研究，测得不同温度下钴盐催化过亚硝酸根分解的催化活性（kcat）。

Using stopped-flow apparatus , the catalytic activities ( kcat ) of cobalt salts for peroxynitrite decomposition at different temperatures were obtained .

固体火箭发动机喷管用的过乙酰硝酸脂材料的发展

Development of Pan Precursor Materials for Solid Propellant Rocket Motor Nozzles

亚甲蓝和乙醇不影响过亚硝酸根的分解速率。

The rate of decomposition was not affected by methylene blue and ethanol .

过亚硝酸根分解反应机制的光度法研究

Spectrophotometric Studies on The Decomposition of Peroxynitrite

生物活性小分子过亚硝酸根

Biological Active Small Molecule Peroxynitrite

邻位取代钴卟啉在所研究浓度下没有催化过亚硝酸根分解的能力，时间分辨谱显示邻位取代钴卟啉不与过亚硝酸根反应形成中间体。

Time-resolved spectrum showed that there was no intermediate formed during ortho-substituted cobalt porphyrins reacting with peroxynitrite .

过亚硝酸根对酪氨酸的硝化损伤是过亚硝酸根体现其毒性的主要途径之一。

The nitration of tyrosine is one of the main manners to exhibit the toxicity of peroxynitrite .

研究了柠檬酸铁和草酸铁对过亚硝酸根硝化酪氨酸反应的影响。

The effects of ferric citrate and ferric oxalate on the nitration of tyrosine by peroxynitrite have been studied .

金属卟啉等金属化合物在体内和体外均可催化过亚硝酸根分解，对过亚硝酸根诱导的硝化损伤有一定的催化作用。

Metalloporphyrins and other transition metal complexes catalyze ONOO - decomposition to scavenge it in vitro and in vivo , and they can catalyze tyrosine nitration induced by peroxynitrite .

败血症休克分子机制之一就是由于线粒体一氧化氮合酶（mtNOS）持续催化NO生成，导致过量过氧化亚硝酸阴离子（ONOO）产生，使线粒体功能异常，肌肉收缩功能减弱。

One of the molecular mechanisms of septic shock is that the enhanced NO production by mitochondrial nitric oxide synthase ( mtNOS ) lead to product excessive peroxynitrite ( ONOO ~ - ), mitochondrial dysfunction and muscle contractile failure .

有人研究过甘油一硝酸脂的性质。

The properties of mononitroglycerine were investigated by some people .

如果在一个地区施了过多的硝酸盐，它会污染当地的水源。

If too much nitrate is used on an area it can contamtnate local water supplies .

蔬菜中过多的硝酸盐对人体健康的潜在危害已成为社会广泛关注的问题，但是，目前对有机基质栽培蔬菜的硝酸盐调控途径及机理的研究报道却不多。

Potential harm of excessive nitrate in vegetables to human bodies has been deeply concerned by the public . However , studies on the measures to regulate nitrate accumulation in vegetables cultivated with organic substrates and corresponded mechanisms were limited .