细胞周期检查点

传统化疗药正定霉素（DR）处理可使其细胞周期检查点蛋白上调。

Traditional chemotherapeutics such as DR treatment can activate the cell cycle checkpoint .

目前胚胎发育过程中损伤修复系统以及细胞周期检查点系统的研究不多，确切作用机制尚不清楚。

But so far there have been few studies investigating the role of DNA damage and repair system or cell cycle checkpoint signal pathways in embryonic development .

p53蛋白参与了细胞周期检查点和DNA修复等多种生命活动中，在维护基因组完整性中发挥重要的作用。

Tumor suppressor protein p53 plays a critical role in the maintenance of genomic stability , participating in many cellular processes such as cell cycle checkpoints and DNA repair .

电离辐射诱导细胞周期检查点蛋白p27～（Kip1）表达及其调控机制研究

The Expression of Cell Cycle Checkpoints Regulator p27 ~( Kip 1 ) and Its Mechanisms of Regulation in DNA Damage Responses

热缺血再灌注损伤影响肝脏细胞周期检查点调控的基因表达分析

Genes expression analysis of cell cycle control in liver warm ischemia-reperfusion injury with microarrays

细胞周期检查点的分子机制

The Molecular Mechanisms of Cell Cycle Checkpoints

细胞周期检查点是确保细胞周期正常运行的一种调控机制。

Cell cycle checkpoints are regulatory pathways that ensure the order and timing of cell cycle transition .

进一步的研究表明它们事实上是DNA损伤-应答激酶，不仅仅是调控细胞周期的检查点。

However , further studies have indicated that they are actually DNA-damage-response kinases , regulating more than just cell-cycle checkpoints .

复制因子C亚单位2（replicationfactorCsubunit2，RFC2）与DNA的复制和修复及细胞周期信号检查点的功能有关。

Replication factor C subunit 2 ( RFC2 ) was reported to be associated with DNA duplication , DNA repair , and the function of cellular checkpoint .

芽殖酵母细胞周期的检查点调控

The Checkpoint Regulation of Budding Yeast Cell Cycle

DNA损伤试剂对HeLa细胞的细胞周期检查点的影响

Effect of DNA Damage Agents on Cell Cycle Checkpoints of HeLa Cells

538~+60区域启动子的调控做了比较全面的分析，着重研究了5′启动子中的血清刺激应答元件以及PCNA在细胞周期DNA损伤检查点（checkpoint）机制中的转录调控。

The serum-responsive element in the PCNA 5 ′ promoter , the transcriptional regulation of PCNA gene in the cell cycle DNA damage checkpoint , were elucidated in detail .

大肠癌细胞周期G1/S期检查点调控的研究进展

The Advances of Checkpoint G_1 / S in The Cell Cycle Regulator of Colorectal Carcinoma

氧化应激性DNA损伤精子体外受精后胚胎细胞在第一次有丝分裂细胞周期启动了G2/M检查点。

1-cell mouse embryos in vitro fertilized with DNA-damaged sperm induced by oxidative stress activates the of G2 / M cell cycle checkpoint to delay the progress of the first mitotic cell cycle .

正常细胞发生DNA损伤或是合成阻断时，将通过细胞周期检查点阻滞在特定的细胞周期内，并诱导某些特殊的转录反应，直到损伤修复后才恢复正常分裂。

Checkpoints respond to DNA damage and DNA replication block by arresting the cell cycle to provide time for repair and by inducing transcription of genes that facilitate repair . Until the damage was repaired , the cell processed into division cycle .

多种细胞机制功能障碍将导致染色体不稳定性，包括染色体分离、DNA损伤反应、细胞周期检查点、端粒功能等。

Several factors , such as defects in chromosome segregation and DNA damage response , failure of cell cycle checkpoint , telomere dysfunction , may cause chromosomal instability .