神经系统变性疾病

肌萎缩侧索硬化（amyotrophiclateralsclerosis，ALS）是一种支配随意运动的上下运动神经元选择性受累的神经系统变性疾病。

Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disease , selectively involving the upper and lower motor neurons that control voluntary movement .

由于该病是一种缓慢进展的神经系统变性疾病，生存期5-20年。

Because the disease is a slowly progressive neurodegenerative disease , survival 5-20 years .

帕金森病（Parkinson'SDisease，PD）是一种常见于中老年人的进行性神经系统变性疾病。

Parkinson 's disease ( PD ) is a common neurodegenerative disorder of unknown cause that occurs in adults .

阿尔茨海默病（AD）是一种以记忆和认知功能障碍为主要症状的中枢神经系统变性疾病，是老年痴呆的常见类型。

Alzheimer disease ( AD ) is a neurodegenerative disorder that results in memory deficits and cognitive decline .

帕金森病（Parkinson'SDisease，PD）是一种好发于中老年的中枢神经系统变性疾病，随着社会人口老龄化的发展，本病的发病率和患病率有逐渐上升的趋势。

Parkinson 's disease ( PD ) is a kind of degenerative disease of the central nervous system in the middle-age and old age .

特发性帕金森氏病（PD）是一种缓慢进展的神经系统变性疾病，病理改变见于中脑黑质纹状体，神经细胞内存在嗜酸性包含体，又称Lewy氏小体。

Idiopathic Parkinson 's disease ( PD ) is a slowly progressive disorder of degeneration of nerve system .

帕金森病（Parkinsondisease，PD）是发生在中年以上常见的人类神经系统变性疾病，主要病变在黑质和纹状体通路，因多巴胺生成减少导致震颤麻痹。

Parkinson disease is a common neurological disorder characterized by occurrence in the middle and old-aged , and main lesion of which is in the substantia nigra and striatum . And paralysis agitans happen for decrease of dopamine production .

肌萎缩侧索硬化（amyotrophiclateralsclerosis，ALS）是一种选择性累及上、下运动神经元的慢性进行性致死性神经系统变性疾病，其病因和发病机制尚不清楚。

Amyotrophic lateral sclerosis ( ALS ) is a fatal neurodegenerative disease characterized by progressive and selective death of upper and lower motor neuron , the etiology and pathogenesis are still unclear .

神经元蜡样脂质褐素沉积病（Neuronalceroid-lipofuscinoses，NCLs）是一组遗传性神经系统变性疾病，具有高度临床变异和遗传异质性。

The neuronal ceroid-lipofuscinoses ( NCLs ) are a large group of progressive neurodegenerative diseases with high phenotypic and genotypic heterogeneity .

方法对110例正常人脑、85例神经系统变性疾病的脑标本及1例嗜银颗粒性痴呆（AGD）病例，进行了嗜银颗粒的病理组织学研究。

Methods The occurrence frequency and pathohistology in AG of 110 normal human brain cases , 85 neurodegenerative disorder cases and one argyrophilic grain ( AGD ) case were studied .

在炎症、缺血及中枢神经系统变性疾病中发挥作用。

It plays roles in inflammation , ischemia and degenerative diseases of CNS .

这种激活细胞自噬的能力对于神经系统变性疾病中的治疗意义重大。

The ability to activate autophagy within these cells could prove invaluable in the treatment of neurodegenerative disorders .

目的：脊髓小脑共济失调是一种遗传性神经系统变性疾病，目前仍无理想治疗方法。

Objective : Spinocerebellar ataxias , which is a hereditary neurological degenerative disorders , are incurable at present .

背景：原发性进行性失语是以语言能力进行性下降，而记忆力相对保存的神经系统变性疾病。

BACKGROUND : Primary progressive aphasia is a degenerative disease of nervous system clinically characterized by the progressive decrease of speech ability and the relatively reserved memory .

神经系统变性性疾病

Degenerative diseases of nervous system

阿尔茨海默病（Alzheimer'SDisease，AD）是一种常见的中枢神经系统退行性变性疾病，其主要临床表现为进行性记忆减退和认知障碍。

Alzheimer 's disease ( AD ) is a common neurodegenerative disease , which is characterized clinically by a progressive loss of memory and cognitive impairment .

大量研究业已揭示，性腺类固醇激素尤其是雌激素在神经系统退行变性性疾病如帕金森病（PD）中具有神经保护作用。

It has been well-known that gonadal steroid hormones , estrogen especially , plays an important role in protecting the brain from neurodegenerative processes , including Parkinson 's disease ( PD ) .

Tau蛋白高度磷酸化形成的神经原纤维缠结主要见于神经系统变性疾病。

Neurofibril tangle formed by high phosphorylation of Tau protein is mainly seen in degenerative diseases of nervous system .

近年来，胚胎和神经干细胞移植在治疗多种神经系统变性疾病中获得成功，NSCs开始广泛用于神经再生、修复和功能重建研究。

Recently , embryonic stem cells ( ES ) and NSCs were utilized successfully in the treatment of many degenerative diseases of central nervous system . NSCs have been widely studied for neural regeneration , restoration , and neural function rebuilding .

帕金森病（Parkinson'SDisease）是以黑质-纹状体多巴胺能神经系统进行性变性为基本病理改变的中枢神经系统变性疾病。

Parkinson 's disease is a common neurodegenerative disorders characterized by the progressive degeneration of dopamine systems in substantia nigra and striatum .

传统观点认为，成人神经细胞损伤后无法再生，功能无法重建，以致中枢神经系统损伤及变性疾病患者的神经功能很难恢复。

The adult neural cells can not regeneration and its function can not rebuild after the injury of them , the neural function of the patients with nervous system damage and neurodegenerative diseases is hard to recover .

在成年人中枢神经系统功能损害性疾病中，脑血管疾病的比例当居首位，其次为神经系统变性疾病、颅脑和脊髓损伤等。

Among the central nervous system diseases and injuries , cerebral vascular diseases have the highest proportion , followed by the nervous system degenerative diseases , brain and spinal cord injury .