碱基缺失

一例由α（1,2）岩藻糖基转移酶基因两碱基缺失引起的类孟买型血型

Two base deletion of the alpha ( 1,2 ) fucosyltransferase gene responsible for para-Bombay phenotype

分析结果表明两株生产菌的purA基因发生了1个碱基缺失，导致阅读框发生移码突变；

A one base deletion is discovered in purA gene from inosine producing strain and guanosine producing strain , which will cause the open reading frame shift mutation .

涎腺淋巴上皮癌中EB病毒潜伏膜抗原-1基因30碱基缺失的研究

Thirty base pair ( 30 bp ) deletion in latent membrane protein 1 oncogene in lymphoepithelial carcinoma of salivary glands

淋病奈瑟菌mtrR基因启动子区的IR区碱基缺失与其耐药性关系的研究

Study of Relationship Between IR Gene Deletion in The mtrR Gene Promoter and Antibiotic Resistance of Neisseria Gonorrhoeae

结外鼻型NK/T细胞淋巴瘤中EB病毒潜伏膜蛋白1基因30bp碱基缺失的检测意义及其与预后的关系

Detection of the 30 base pair deletion of Epstein-Barr virus latent membrane protein 1 in extranodal nasal type NK / T-cell lymphoma and its prognostic significance

结果表明，PCR扩增获得的片段为939bp，与中国西门塔尔牛该段序列相比，同源性为97.44%，在-720bp处的1个碱基缺失；

The result showed that the PCR product of buffalo FSHR is 939 bp . Compared with the Chinese Simmental , the homology of this sequence is 97.44 % and there is 1 bp absence in-720 bp .

和活体标本的18Srdna序列相比，标本DNA的碱基缺失率为7%，碱基替换比例为11%。

Compared with live specimen , 80 % bases of 18S rDNA sequence are identical , 7 % are deleted , and 11 % are replaced in formalin-fixed specimen .

非编码区亦存在单个碱基缺失及置换突变。

In non-coding region it shows mutation of single nucleotide deletion or substitution .

结果：两种方法均能得到重组质粒，但是双链PCR法构建效率高且不易引起碱基的缺失和突变。

Results : Recombination vectors were obtained by both methods and better cloning efficiency was achieved and rare base deletion and mutant were found in the PCR method .

两分离株的F基因都没有碱基的缺失和插入，但有多处点突变，分散存在。

None of the F genes of the isolated NDV virulent strains suffered any base deletion and insertion , but there are mutations in many points scattering about .

有趣的是两个突变体中都发生了单个碱基的缺失，PCR-RFLP证实了该结果。

Interestingly , both mutant alleles had a single-base deletion , which was confirmed by PCR-RFLP .

钙调神经磷酸酶B亚基（PPP3R1）启动子区域新的5个碱基对缺失的识别及其与左心室肥厚的关系

Identification of a novel 5-base pair deletion in calcineurin B ( PPP3R1 ) promoter region and its association with left ventricular hypertrophy

所有移码突变表现为1～2个碱基的缺失或插入，大多（7/9）发生在简单核苷酸重复序列，特别是单腺苷酸重复序列（A）n（5/9）。

All of frameshift mutations were deletion or insertion of 1 2 bp and most of them ( 7 / 9 ) happened at simple nucleotide repeat sequences , particularly within ( A ) n tracts ( 5 / 9 ) .

测序发现co-9中CO基因编码区中有10个碱基的缺失导致了CO蛋白C末端92个氨基酸没有被合成，这其中包含一个CCT结构域。

The late-flowering phenotype was not resumed by applying exogenous gibberellin . A 10 nt fragment deletion was found in the coding region of CO gene , resulting in premature termination of CO protein and the absence of the 92 amino acids of C-terminal domain .

267位碱基T缺失。

An absence of T base at position 267 . U.

结果5株菌均发生了A/T单个碱基的缺失。

Results Single-base deletion of A / T was observed in all 5 strains .

其中也包含有一个位点连续三个碱基的缺失突变和一个位点一个碱基的插入突变。

The eminent differences were also a continuous delete mutation of three nucleotides at one site and one insert mutation of a single nucleotide at another site in Yunnan yak ′ s genome .

本研究同时提出了水稻稻米糊化温度调控的分子遗传假说，认为基因编码区内碱基插入、缺失或替换可能是GT改变的遗传基础。

A hypothesis for molecular mechanism for GT variation of rice is presented , that is DNA insertion , deletion or base substitution in coding sequence of alk contributes to GT variation of rice .

与GenBank中另外2种小沙丁鱼的同源序列比对，去除部分端部序列后得到599bp同源序列，其中包括445个简约信息位点，154个变异位点，没有发现碱基的插入缺失。

A total sequence of 599 nucleotide base pair was obtained by alignment with homologous sequences of another two Sardinella species in GenBank . There were 445 parsimony-informative sites and 154 variation sites , but no insertion / deletions were observed .

有2处较大的碱基插入/缺失突变。

There existed much greater mutation of insertion / absence at 2 locations .

9例为点突变，其中错义突变4例、无义突变2例、同义突变3例，其余2例为碱基插入和缺失导致的移码突变。

There were 9 point mutations , including 4 missense mutations , 2 nonsense mutations , 3 silent mutations . The other 2 cases were frameshift mutations due to base insertion and deletion .

在获得的426bp序列中，A+T含量约占65.0%，有4个多态位点，无任何碱基插入和缺失。

Of the 426 bp mitochondrial cytochrome b DNA sequences obtained , A % + T % was about 65.0 % , four nucleotide sites were substituted , and no base composition of the sequences was inserted and lost .

结果表明，在COI基因片段中，存在碱基的插入或缺失。

Results of the mitochondrial COI gene sequence revealed that deletion / insertion were detected among COI gene fragments .

侧翼序列个别碱基的插入或缺失；

Having deletion or insertion of one or two base ( s ) in flanking sequence ;

该序列在3个位点处发生转换型突变，未发现碱基的增加、缺失以及颠换型突变。

Nucleotide base transitions were found at 3 loci in the sequence , while there is no insertion , deletion and transversion mutation .

1例85密码子第2、3碱基之间插入A，同时86密码子第2碱基缺失，即GCA→GA导致无义突变。

Case had 1 base pair insertion TT → TAT in 85 codon and 1 base pair deletion GCA → GA , which may result in nonsense mutation .

在检测到的24个碱基突变中，主要是碱基的置换（87.5%），碱基缺失的比例比较小（12.5%）。

In all of the 24 bases of mutants , the base replacement occupies about 87.5 % of the total mutants with only a small portion of gene deletion ( 12.5 % ) .

研究结果表明，IFP2的末端反向重复序列上每一个位点的碱基都对转座子活性有重要的影响，任何一个位点碱基的缺失都会导致转座子不能进行识别和剪切。

The results showed that every base in ITR sequences was important for the activity of transposons . Deletion of any base could result in failture of identification and cut of the transposons .

突变可以是DNA的单个碱基变化（点突变）或一个基因中的一对碱基对丢失（缺失突变），或染色体的一段移位从而影响很多基因。

Mutations can be a change in a single base of DNA ( point mutation ) or a loss of base pairs ( deletion ) affecting a single gene , or a movement of chromosomal regions ( translocation ) affecting many genes .

通过Mega软件对所得线粒体控制区序列的片段进行比较，共检测出114个碱基存在变异，其中包括84个简约信息位点，5个碱基存在插入/缺失；

And then , comparing the control region fragments with each other by Mega software , 114 sites were variable among all the partial mitochondrial control region sequences including 84 parsimonious message sites and five deletion / insertion sites .