牡荆素

牡荆素的飞行时间质谱

Time of Flight Mass Spectrometry of Vitexin

对有效部位进行了化学成分分离，得到了三个化合物，分别为牡荆素、牡荆素鼠李糖苷、牡荆素葡萄糖苷。

Three compounds were isolated from the active part and identified as vitexin , vitexin glucoside , vitexin rhamnoside NMR data and physical and chemical character .

FITC标记Annexin-V/PI双染流式细胞术结果表明：紫花牡荆素诱导SGC-7901细胞凋亡百分率增高（P0.05），且呈时间和剂量依赖性。

Data of flow cytometry of FITC-Annexin-V / PI double staining demonstrated that casticin significantly induced increase of the percentage of apoptotic cells ( P0.05 ), in a time - and concentration-dependent manner .

紫花牡荆素抗肿瘤作用及其作用机制

Anti-tumor effect of casticin and its mechanism

利用台式飞行时间质谱的中分辨本领，研究了牡荆素的电子轰击质谱的裂解规律，对裂解途径进行了完全的指认。

Using moderate resolution capabilities of a desk time-of-flight instrument , the fragmentation regularity from electron impact mass spectra of cilnidipine is reported .

牡荆素主要通过肝脏和肾脏代谢排泄，在大鼠尿、粪和胆汁中的总排泄量约为给药量的30%。

Vitexin was mainly excreted through bile , and urine , and the total percentage of the corresponding cumulative excretion was found to be nearly 30 % in the bile , urine and feces .

山楂叶中的黄酮类化合物如芦丁、金丝桃甙、槲皮素、牡荆素等，是其主要的有效成分，可以起到降压、降血脂、增大心脏血流量等作用。

The flavonoid ingredients , such as rutin , quercetin , hypericin and vitexin , are main efficient components in Hawthorn leave , which reduce blood pressure and blood lipid , while improve cardiac output .

结论：牡荆素鼠李糖苷能通过蛋白及基因水平有效地调节缺氧再给氧损伤血管内皮细胞产生的血管活性物质的表达。

Conclusion : We have demonstrated that V-R had the regulatory effect on the expression of vaso-active substances of EC damaged by hypoxia and reoxygenation in the levels of protein and gene transcription of cytokines .