氟他胺

抗雄激素物质氟他胺作用于受孕SD大鼠引起尿道下裂的机制研究

Mechanism of Antiandrogen Flutamide Causing Hypospadias on Pregnant SD Rat

目的初步确定氟他胺（flutamide，Flu）肝毒性发生的机制。

Purpose To study the liver toxicity mechanism of flutamide in SD rats .

氟他胺对F1雄性大鼠睾酮分泌的影响机制

The mechanism of testosterone secretion of F1 male rat with flutamide

雄激素拮抗剂氟他胺也能够部分抑制（50%）睾酮对细胞内AR蛋白水平的上调作用。

Furthermore , androgen up-regulation of intracellular AR protein was partially inhibited ( 50 % ) by nonsteroidal androgen antagonist , flutamide .

2例术后PSA未降至正常，加用氟他胺行辅助内分泌治疗后逐渐降至正常。

Cases had not decreased to normal PSA , plus flutamide adjuvant hormone therapy , they gradually returned to normal .

方法对24例前列腺癌（C期10例，D期14例）采用联合雄激素阻断（双侧睾丸切除+氟他胺）治疗。

Methods 24 cases of advanced prostate cancer ( 10 in stage C and 14 in stage D ) were retrospectively studied . All the patients have been treated with combined androgen blockade ( bilateral orchiectomy and flutamide ) .

氟他胺（Flutamide）的抗雄性素作用及抗肿瘤作用

Anti-androgenic and Anti-tumor Activity of Flutamide

方法：回顾性分析21例晚期前列腺癌病人，应用药物诺雷德去势加氟他胺（甲组）或康士得IAD方法（乙组）治疗的结果。

Method 21 patients treated with IAD by LHRH analogues ( zoladex ) and androgen blockade ( flutamide or cascodex ) were reviewed retrospectively .

然后用双氢睾酮和氟他胺在体内和体外实验中对上述三种LNCaP前列腺癌亚细胞株的生长特性及其雄激素依赖性进行研究，以论证所建立的前列腺癌细胞模型。

The growth characteristics and androgen-dependence of the three LNCaP sublines were determined by flutamide and DHT in vivo and in vitro .

目的探讨肝癌癌变过程中雄性激素受体的动态变化及氟他胺（flutamide）对受体和成癌的影响。

Objects [ WT5BZ ] To investigate changes of androgen receptor ( AR ) in hepatocarcinogenesis and influence of flutamide on the expression of AR and carcinogenesis .

目的观察诺雷德（Zoladex）和氟他胺（Flutamide）治疗晚期前列腺癌的临床疗效，分析影响疗效的有关因素。

Objective To observe the clinical effect of advanced prostate cancer treated by Zoladex and Flutamide , and analyze the related factors influencing curative effect .

方法在LNCaP细胞中加入氟他胺，然后抽提正常LNCaP细胞和加入氟他胺的LNCaP细胞中的mRNA制备cDNA探针，应用基因芯片技术观察两者细胞周期基因表达差异情况。

Methods Flutamide was added to LNCaP cells . The mRNA from both experiment group cells and the control group cells was extracted to make cDNA probes . The difference in the expression of cell cycle related genes was observed in both groups by genechips .

氟他胺是非甾体类雄激素拮抗剂，用于治疗前列腺癌100例，采用美国生产缓退瘤（Fugerel）治疗前列腺癌31例作为对照组。

Flutamide is a nonsteroidal antiandrogen and is used to treat prostatic cancer . This study compared Flutamide tablet and Fugerel ( Schering Plough Carp , USA ) in the treatment of Prostatic cancer ( 100 cases for Flutamide V. S. 31 cases for Fugerel ) .

氟他胺对大鼠肝生物转化酶和抗氧化功能的影响

Influence of Flutamide on Liver Biotransformation Enzymes and Antioxidation in Rats

氟他胺撤退综合征（附78例报告）

Flutamide withdrawal syndrome ( report of 78 cases )

氟他胺和二甲双胍在难治性多囊卵巢综合征中的临床应用

Clinical effect of flutamide and metformin on patients with complicated polycystic ovary syndrome

小剂量氟他胺对大鼠性分化影响的实验研究

Impact of Flutamide on Sex Differentiation in Rats

抗癌药氟他胺的合成研究

Research on Synthesis of Anticancer Drug Flutamide

氟他胺加睾丸切除治疗晚期前列腺癌22例报告

Orchiectomy with Oral Flutamide in Treating Advanced Prostate Carcinoma & Clinical Report of 22 Cases

菌核净的抑制作用较氟他胺弱，约为氟他胺的1/100。

The inhibiting potency of dimethachlon was about 1 / 100 of that of flutamide .

氟他胺耐受前列腺癌动物模型的建立

Establishment of flutamide insensitive animal model

雄激素拮抗剂氟他胺在先天性肾上腺皮质增生症治疗中应用探索

Pilot study on application of antiandrogen ( flutamide ) in the treatment of congenital adrenal hyperplasia

氟他胺联合去雄激素环境诱导的雄激素非依赖性前列腺癌细胞模型的建立

Establishment of an Androgen-independent Prostate Cancer Cell Line Induced by the Combined of Flutamide and Androgen-free Environment

诱发性肝癌雄性激素受体的动态变化及氟他胺对受体表达和成癌的影响

Change of androgen receptor in induced hepatoma and influence of flutamide on expression of androgen receptor and hepatocarcinogenesis

目的采用抗雄激素类药物氟他胺诱导建立大鼠尿道下裂动物模型，为进一步研究尿道下裂发病的分子作用机制和治疗提供理论和实验依据。

Objective To establish a rat model of hypospadias by flutamide to further studying molecular mechanisms of hypospadias etiology .

她发现，二甲双胍、胰岛素增敏剂？格列酮和氟他胺一起服用的效果好于口服避孕药。

She found that metformin , an insulin sensitizer called pioglitazone and flutamide taken together performed better than oral contraceptives .

氟他胺与螺内酯联合达英35治疗特发性多毛症临床疗效比较的随机对照研究

Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism : A randomized controlled study

目的建立人血浆中2-羟基氟他胺的HPLC-MS/MS测定法，研究氟他胺片生物等效性。

OBJECTIVE To develop an HPLC-MS / MS method for the determination of2-hydroxyflutamide in human plasma and evaluate the bioequivalence of flutamide tablets .

方法136例前列腺癌患者采用联合雄激素阻断治疗（睾丸切除+氟他胺或福至尔，250mg/次，3次/d）。

Methods One hundred and thirty-six patients with adenocarcinoma of the prostate were treated with combined androgen block ( orchiectomy and flutamide 250 mg , Tid ) .

然而，同时补充氟他胺使去睾丸雄兔动脉粥样斑块的面积显著、内膜厚度增加，并使斑块纤维帽厚度减低、胶原含量下降。

However , presence of flutamide increased the plaque area , the aortic intimal thickness and decreased the fibrous cap thickness and collagen contents in castrated rabbits again .