格列齐特

气相色谱法测定格列齐特中残留乙醇和N，N-二甲基甲酰胺的量

Determination of ethanol and DMF remained in Gliclazide

国产格列齐特的有效剂量明显低于进口格列齐特（P＜0.05）。

The effective dosage of domestic gliclazide was lower than that of imported gliclazide ( P < 0.05 ) .

HPLC分离测定格列齐特片及其有关物质

Determination of gliclazide and its related substances in gliclazide tablets by HPLC

格列齐特对糖尿病大鼠心肌ATP敏感性钾通道mRNA表达的影响

Effect of Gliclazide on mRNA expression of ATP-sensitive potassium channels in myocardium of diabetic rats

结果DSC曲线和TG曲线证明乳糖和格列齐特一定比例下形成共熔体。

Results From the graphs of DSC and TG , solid dispersion was formed in the procedure .

目的：建立新的HPLC法分离测定格列齐特片及其有关物质。

OBJECTIVE : To develop a new HPLC method for isolation and determination of gliclazide and its related substances .

格列齐特渗透泵片在Beagle犬体内的药动学

Pharmacokinetics of gliclazide osmotic pump tablets in Beagle dogs

改进了测定人血清中格列齐特（1）的HPLC方法；在10名健康志愿者体内，研究了两种国产1片剂的相对生物利用度。

A reversed-phase HPLC method was developcd for determination of gliclazide in human serum to study the relative bioavailability of two brands of domestic tablets in10 healthy volunteers .

对冬凌草片、格列齐特片和盐酸雷尼替丁胶囊分别用PLS和判别分析建立其定量和定性模型。

The quantitative and qualitative models were established by PLS and discriminant analysis for the rabdosia rubescens tablets , gliclazide tablets and ranitidine hydrochloride capsules .

分别以格列齐特和碘海醇为研究对象，建立了化学原料药中19种金属杂质的ICP-AES测定法。

An inductively coupled plasma-atomic emission spectrometry method was established to determine nineteen elemental impurities in chemical bulk drugs simultaneously by choosing gliclazide and iohexol as research object .

结论国产格列齐特缓释片能有效地降低FBG、2hBG以及HbA1c水平。结论格列齐特缓释片和普通片可在有效降低T2DM患者血糖的同时，改善血管内皮功能。

Conclusions Both gliclazide and slow-released gliclazide can improve the endothelial functional dependent dilatation and serum glucose level in type 2 diabetics .

结果：2001～2003年我院口服降糖药的DDDs呈现逐年上升，其中格列齐特、甲苯磺丁脲、二甲双胍位居前列；

Result : The DDDs of oral antidiabetic agents rised gradually from 2001 to 2003.The front of DDDs were among Gliclazide , Tolbutamide and Metformin .

目的：建立快速、灵敏、专属的液相色谱-串联质谱（LC／MS／MS）法，测定人血浆中的格列齐特浓度，并应用于格列齐特缓释片人体生物等效性评价。

Aim To develop and validate a rapid , sensitive and selective LC / MS / MS method for the determination of gliclazide in human plasma and to evaluate the bioequivalence of gliclazide modified release tablet by the validated LC / MS / MS method .

心肌转化生长因子β1蛋白和mRNA水平：马来酸罗格列酮组、格列齐特组及糖尿病未治疗组明显高于正常组（P<0.01,0.05），马来酸罗格列酮组明显低于糖尿病未治疗组（P<0.05）。

TGF β 1 protein and mRNA : The Avandia group , Gliclazide group and diabetes group were significantly higher than that of the normal group ( P < 0.01 , 0.05 ), and the Gliclazide group was obviously lower than the diabetes group ( P < 0.05 ) .

格列齐特混悬剂的制备及物理稳定性的研究

Preparation of suspension of gliclazide and studies on the physical stability

难溶性药物格列齐特口服控（缓）释制剂的研究

The Study of Gliclazide Oral Controlled ( Sustained ) Release Formulations

格列齐特缓释片的制备及其释药因素考察

Preparation of gliclazide sustained-release tablets and influencing factors on its release

非配体依赖性受体激活格列齐特治疗非胰岛素依赖性糖尿病的疗效

Ligand-independent receptor activation Therapeutic effects of gliclazide in non-insulin-dependent diabetes mellitus

国产格列齐特片（Ⅱ）在健康人体内的药动学研究

Pharmacokinetics of domestic and imported gliclazide tablets (ⅱ) in healthy volunteers

格列齐特缓释片的研制及体外释放度考察

Preparation and Dissolution of Gliclazide Sustained Release Tablets in Vitro

方法采用混合骨架材料制备格列齐特缓释片；

METHODS : Mixed matrix materials was used to prepare the tablet .

应用国产格列齐特治疗非胰岛素依赖型糖尿病106例，并以格列本脲（优降糖）作对照药物。

Gliclazide was used to treat 106 patients with noninsulin-dependent diabetes mellitus .

格列齐特渗透泵控释片的制备及犬体内药动学

Preparation and Pharmacokinetics in Beagle Dogs of Gliclazide Osmotic Pump Controlled-release Tablets

目的：对格列齐特缓释片进行质量标准研究。

Objective : To study the quality specification of Gliclazide Sustained-release Tablet .

格列齐特对老年糖尿病患者冠状动脉血流储备变化的初步观察

The effects of treatment with gliclazide on coronary flow reserve in elderly diabetic

此外，格列齐特还可降低红细胞最大聚集指数；

In addition , erythrocyte maximal aggregation index was decreased in gliclazide group .

格列齐特缓释微丸胶囊的制备及体外释放度考察格列齐特缓释微丸胶囊的研制

Study on Preparation and Dissolution Test in Vitro of Gliclazide Extended-release Pellet Capsule

建立了单扫描示波极谱法测定格列齐特片的含量。

A single sweep oscillopolarography method was established for the determination of gliclazide tablets .

3-氮杂双环[3.3.0]辛烷1是合成格列齐特的关键中间体。

3-azabicyclo [ 3.3.0 ] octane 1 is a key intermediate of synthesizing gliclazide .

格列齐特治疗非胰岛素依赖型糖尿病106例的近期疗效

Short-term efficacy of gliclazide in the treatment of noninsulin-dependent diabetes mellitus in 106 patients