性早熟

中华绒螯蟹人工培育幼蟹过程中，缺少必需的维生素C的添加，会导致约14%左右的雌性个体性早熟出现。

During the process of artificial cultivating the young crabs of eriocheir sinensis , if lacking to add the essential Vc , then it will cause about 14 % female individualities to appear the pubertas praecox .

缓释型促性腺激素释放激素拟似剂治疗性早熟的疗效观察

The observation on the therapeutic effect of the slow-release analog of the gonadotropin releasing hormone on pubertas praecox

中华绒螯蟹幼蟹的维生素C摄取与克服性早熟

To Absorb the Vitamin C from the Young Crabs of Eriocheir Sinensis and Overcome Pubertas Praecox

G蛋白偶联受体54mRNA在雌性性早熟大鼠下丘脑中的表达及其意义

Expression of Hypothalamic G Protein-Couple Receptor 54 mRNA in Female Rats with Precocious Puberty and Its Significance

达那唑诱导的雌性性早熟大鼠GnRH及其受体mRNA的表达

Expressions of GnRH and GnRH receptor mRNA in female rats with danazol-induced precocious puberty

皮下注射N甲基DL天冬氨酸是诱发雌性大鼠真性性早熟的有效手段。

Subcutaneous injection of NMA is an effective means to induce true precocious puberty in female rats .

性早熟现象与其体内Vc的含量不足存在着正相关。初步判断，Vc源的缺乏或不足是造成幼蟹性早熟的重要原因。

According to the initial judgement , lacking Vc resources is the main reason to cause the pubertas praecox of young crabs .

结论血清瘦素、IGF-1、脑电图可作为真性性早熟的早期诊断指标之一。

Conclusion Serum leptin , IGF-1 , EEG are of diagnostic value to precocious puberty .

目的研究假性性早熟（PPP）的病因、临床特征、诊治及预后。

Objective To study the causes , clinical feature , diagnoses and prognosis of pseudoprecocious puberty .

性早熟的发生与肝胰腺中ACP和ALP活性的显著升高有关。

Onset of precocity was related to significant elevation of activities of ACP and ALP .

LHRH激发试验在儿童性早熟诊断及治疗中的应用

Therapeutic and diagnostic application of LHRH stimulation test in precocious puberty

方法分别采用醋酸甲羟孕酮4～20mg/d口服和醋酸亮丙瑞林60～90μg/（kg·月），每4周1次，皮下注射治疗女童性早熟74例。

Methods Seventy-four with CPP were treated with medroxyprogesterone acetate 4 ~ 20 mg / d orally and leuprorelin acetate 60 ~ 90 μ g / kg subcutaneously injection at monthly intervals .

性早熟儿童IGF-Ⅰ和IGFBP-3水平的观察

The observation of serum IGF - ⅰ 、 IGFBP-3 levels in children sex precocity

Logistic回归分析结果表明营养滋补品，成人洗漱护肤品，自觉课业负担沉重与儿童性早熟密切相关（P<0.01）。

Logistic regression showed that nutritious and moisten products , skin care cosmetic for adult , over burdened homework had statistic significant differences among precocious puberty children ( P < 0.01 ) .

方差分析的结果表明，蟹种的个体生长率随放养密度的递增而下降，组间差异极为显著（P＜0.01），性早熟比例与密度递增组间差异不明显；

Results of variance analysis showed the individual growth rate of crab decreased with the increase of stocking density and the difference was quite significant ( P < 0.01 ) . Ratio of pre maturation was not obviously related with stocking density .

GnRH-a治疗真性性早熟的临床研究

GnRH-a treatment of precocious puberty in clinical research

结论：①NMA诱导的雌性大鼠性早熟模型是真性性早熟模型；

Conclusions : ① The NMA induced precocious puberty rat model is ture precocious puberty model .

实验采用称量法和气相色谱法分别测定了性早熟前后中华绒螯蟹的肝胰腺指数（HI）、肝脂含量（LC）和肝胰腺脂肪酸组成。

The hepatopancreas index ( HI ), lipid content ( LC ) and fatty acid composition in Eriocheir sinensis before and after the precocity , were compared by gravimetry and gas chromatography .

结论：如患儿临床上表现为性早熟和痴笑样癫痫，影像学上显示灰结节或乳头体肿块，具有典型CT和MRI表现，应首先考虑本病。

Conclusion : If a child suffered from precocious puberty or gelasmus epilepsy , together with CT and MRI characteristics of the mass near the tuber cinereum or mammillary body , the diagnosis of hypothalamic hamartoma might be considered first .

【目的】探讨简化促性腺激素释放激素（GnRH）兴奋试验在女性性早熟症诊断中的意义。

【 Objective 】 To explore the clinical value of simplified gonadotropin releasing hormone ( GnRH ) test in the management of female precocious puberty .

血清IGF1、IGFBP3及OST用于判断性早熟儿童骨骼发育异常及疗效

The significance of measuring serum IGF_1 , IGFBP_3 and OST for the judgement of abnormal skeletal development and therapeutic monitoring in precocious children

方法对42例女性同性性早熟患者施行简化GnRH兴奋试验，其中38例患者平均随访26（3～78）个月，观察患者的临床表现及病情发展情况。

Methods Simplified GnRH stimulating test was performed in 42 girls with IPP . Thirty-eight of them were followed-up for a mean of 26 ( 3-78 ) months .

结论简化GnRH兴奋试验有助于女性同性性早熟症发病原因的诊断，及客观判断下丘脑垂体卵巢轴是否被激活，较临床指标更为可靠。

Conclusion Simplified GnRH test is helpful to objectively evaluate activation of the hypothalamic-pituitary-ovary axis , and is more reliable than those clinical features in differential etiological diagnosis of female IPP .

该制剂能显著降低白兔因性早熟引起的激素E2、PROG、TESTO、LH、FSH含量偏高，使其接近正常水平。

The experiment shows that the preparation can reduce the rabbit levels of hormone E2 . PROG , TESTO , LH , FSH and lead them to normal levels .

目的：观察滋阴泻火中药对达那唑诱导的性早熟模型大鼠下丘脑促性腺激素释放激素（GnRH）和垂体GnRH受体mRNA表达的影响，探讨滋阴泻火中药的作用机制。

Objective : To probe the mechanism of Chinese herbal medicine ( CHM ) for nourishing Yin and purging Fire on the expressions of gonadotropin-release hormone ( GnRH ) and its mRNA expression in hypothalamus and GnRH receptor mRNA in pituitary in danazol induced precocious puberty model rats .

目的评价促性腺激素释放激素类似物（GnRHa）联用重组人生长激素（rhGH）治疗对于改善真性性早熟（CPP）女孩预测成年身高（PAH）的疗效。

Objective To evaluate the effect of combined treatment with gonadotropin-releasing hormone analog ( GnRHa ) and recombinant human growth hormone ( rhGH ) on predicted adult height ( PAH ) in girls with central precocious puberty ( CPP ) .

结论：滋阴泻火方能抑制NMA诱导的雌性大鼠性早熟的发生，并使其维持在正常青春前期状态，其作用与亮丙瑞林相似。

Conclusions : ① CHM for nourishing Yin and purging Fire , as well as Leuprorelin , were able to inhibit the occurrence of the true precocious puberty induced by NMA in female rats , and remain the rats in normal prepuberty status .

结果表明，性早熟大黄鱼脑垂体许多促性腺激素分泌细胞的胞质出现空泡，提示性早熟的原因可能是由于GtH细胞提早进入分泌活动所致。

The present results indicate that it occurred vacuole in the cytoplasms of many gonadotropic cells in the pituitary of gonadal precocity , which shows that the cause of gonadal precocity may be due to entering the secretory activity of GtH cells in pituitary .

总之，儿童性早熟可能是一种涉及到基因调控和表达的疾病，滋阴泻火中药合剂可从分子水平，在多个层次调整异常的HPGA功能。

In sum , the expression and regulation of certain genes may be involved in the pathogenesis of precocious puberty , and the targets of CHM that effectively treat this disease may just at the level of gene .

文昌鸡性早熟，母鸡127d产蛋率5%，182d产蛋率50%，300d产蛋量73个，平均蛋重37.6±3.2g。

Wenchang fowl was precocious . The egg production rate of the hen at 127d and 182d was 5 % and 50 % , respectively , with an average egg weight of 37.6 ± 3.2g .