广防己

急性毒性实验显示广防己水煎液小鼠LD（50）为69.8305g／kg。

Acute toxic test shows that LD_ ( 50 ) is 69.8305g/kg .

结果：与空白组对照，大剂量广防己组尿AKP明显升高（P<0.05）；

Results : Compared to blank group , the concentrations of AKP were significantly higher ( P < 0.05 ) in high dosage group .

报道海南岛4种新记录植物，包括广防己AristolochiafangchiY。

Four species are reported as new records for Hainan Island , China . They are Aristolochia fangchi Y.

目的：观察广防己醇提取物（RAFE）急性以及不同剂量的RAFE对肾脏慢性毒性。

Objective : To observe the acute and chronic renal toxicity induced by Radix Aristolochiae Fangchi Extract ( RAFE ) in different doses in rats .

结论：毒性剂量下的广防己提取物在大鼠体内的代谢符合血管外给药二室开放模型，AA-I及AL-I的组织分布较广泛，其蓄积具有特异性。

Conclusion : The metabolism of Aristolochia Fangchi extract in a toxic dose was correspondence to two-compartment model , and the distribution of AA-I and AL-I was wide and the accumulation of them was specific .

不同配伍药物拮抗广防己肾毒性的实验研究

Experimental Studys on different matching herbs antagonizing the kidney toxicity of Radix Aristolochiae Fangchi

结论滋阴补肾丸可显著降低广防己中马兜铃酸A的含量。

Conclusion Ziyin Bushen Pill can markedly decreased Aristolochhia acid A content of Aristolochia fangchi .

广防己致大鼠慢性肾小管-间质损伤的实验研究Ⅱ

Experimental study of chronic renal tubular-interstitial injury induced by Radix Aristolochiae Fangchi extract in rats

中药广防己与粉防己总提取物利尿效应及肾毒性比较研究

Characterization of diuretic effect and nephrotoxicity of the Aristolochia fangchi total extract in comparison with Stephania tetrandra

生地对广防己减毒作用最佳配伍比例的研究参知健脑片有效组分的最佳配伍筛选

Study on Best Comparability Ratio of Radix Rehmanniae with Radix Aristolochiae Fangchi for Attenuation of Toxicity The Best Combination of Effective Screening Component