少突胶质细胞

资料综合：Nogo-66受体1是髓鞘糖蛋白、少突胶质细胞髓鞘糖蛋白以及Nogo的共同受体。

DATA SYNTHESIS : Nogo-66 receptor 1 is the common receptor of myelin associated glycoprotein , oligodendrocyte myelin glycoprotein and Nogo .

在培养细胞系统，已经发现OPC有分化成多种细胞的潜能，它能够分化成少突胶质细胞和星形胶质细胞[6]，甚至还能分化成神经元[7]。

In the system of cell culture , OPCs have proved to have the potency of cell differentiation , such as differentiating into oligodendrocyte cells , astrocytes , even neurons .

烫伤后3h，少数神经细胞及少突胶质细胞轻度肿胀。

Nervous cells and oligodendrocytes became to swell lightly at 3 hour after scald .

SOX蛋白与少突胶质细胞的发育

SOX Protein and Development of Oligodendrocytes ALBUMINOUS CELLS

体外培养条件下钾离子对少突胶质细胞表达MBP的影响

Investigation on the influence of potassium on oligodendrocytes expressing myelin basic protein in vitro

2移植的NSC在宿主视网膜内可以分化为星形胶质细胞、少突胶质细胞和神经元。

The grafts differentiate into both glia and neuronal cells after transplantation .

在不同的培养环境下OPC可分化为星形胶质细胞、少突胶质细胞甚至分化为神经元[17]。

Generally , OPC is a precursor cells which can differentiate astrocytes and oligodendrocytes , even neurons In different culture environment .

在含血清培养基中培养时NSCs可被诱导分化，分化后的细胞分别表达神经元细胞、星形胶质细胞和少突胶质细胞的特异性抗原。

Serum midium induced these NSCs to differentiate and express specific antigens of neuron , astrocyte and oligodendrocyte .

多发性硬化症（MultipleSclerosis，MS）的主要病因是成熟的少突胶质细胞损伤或死亡，从而产生髓鞘缺失。

The major reason for multiple sclerosis ( MS ) is the severe injury and death of mature oligodendrocytes , which in turn causes the loss of the myelin sheaths .

免疫荧光染色检测脊髓损伤处的神经元、星形胶质细胞及少突胶质细胞数量随时间推移逐渐增加，E+NSCs组与其他各组之间均存在差异（P＜0.01）。

The number of neurons , astrocytes and oligodendrocytes keratinocyte in injured site gradually increased over time by immunofluorescence stain . Difference between E + NSCs group and other groups respective was obvious ( P0.01 ) . Conclusion : 1 .

使用降低剂量强度的PCV方案对少突胶质细胞瘤化疗：来自新加坡的经验

Oligodendroglial tumor chemotherapy using decreased - dose - intensity PCV : A Singapore experience

目的：比较亚洲型和西方型髓磷脂少突胶质细胞糖蛋白（MOG）基因的多态性与比较亚洲型和西方型多发性硬化（MS）患者。

Aim : To explore the association of myelin oligodendrocyte glycoprotein ( MOG ) gene polymorphisms with multiple sclerosis ( MS ) .

结果：经流式细胞术获得了细胞膜表达Nogo-A的成熟少突胶质细胞，比例为3.36%。

Results : The percentage of mature oligodendrocytes with Nogo-A expression in membrane was 3.36 % .

少突胶质细胞髓鞘糖蛋白是糖基磷脂酰肌醇锚合蛋白，富含亮氨酸重复片段结构域，参与蛋白间的相互作用，发挥DNA修复、RNA剪接、细胞间黏附及信号转导等功能。

OMgp , a glycosyl-phosphatidyl inositol anchor protein , was rich in leucine repeated segments , participated in interaction among protein , had the function of DNA repair , RNA splicing , cell adhesion , signal transduction and so on .

神经干细胞（NSC）是具有高度自我更新能力并能分化为神经元、星形胶质细胞和少突胶质细胞的神经前体细胞。

Neural stem cells ( NSCs ) have the ability of highly self-renewal and can be differentiated into neurons , astrocytes and oligodendrocytes .

已有实验证明Lingo-1对少突胶质细胞的分化和髓鞘形成起负性调控作用。

Lingo-1 has been identified as a negative regulator of oligodendrocyte differentiation and myelination .

目的了解高苯丙氨酸（Phe）对中枢神经系统少突胶质细胞（OLG）NogoA表达的影响。

Objective To study the effect of high phenylalanine on Nogo A mRNA and protein expression of oligodendrocyte ( OLG ) .

脊髓横断组髓磷脂碱性蛋白（MBP）阳性的少突胶质细胞数目的时间及空间分布与正常对照组相比无统计学差异（P>0.05）。

The number of myelin basic protein ( MBP ) immunopositive oligodendrocytes in SCI groups was not obviously different from that in the control group ( P > 0.05 ) .

目的：探讨蛋白脂蛋白（PLP）在分化成熟的两型星形胶质细胞和少突胶质细胞中的表达。

Objective : To explore the expression of proteolipid protein ( PLP ) in mature type-1 astrocytes , type-2 astrocytes and oligodendrocytes .

少突胶质细胞肿瘤染色体1p、19q和10q杂合性缺失与临床预后的关系

Relationship between loss of heterozygosity on chromosome 1p , 19q and 10q and clinical prognosis in oligodendroglial tumors

Nogo-A是一种髓鞘源性抑制蛋白，主要存在于中枢神经系统神经元和少突胶质细胞中，对轴突生长表现出强烈的抑制作用。

Nogo-A is a myelin-derived inhibitory protein , which exists in the central nervous system neurons and oligodendrocytes , and shows a strong inhibition in the axon growth .

OLIG1对人少突胶质细胞瘤鉴别诊断意义的实验研究变性高效液相色谱检测少突胶质细胞瘤1p杂合性缺失

Experimental Study on the Distinct Diagnostic Significance of OLIG I to Oligodendroglial Tumors ; Identifying 1p LOH in Oligodendroglioma with Denaturing High Performance Liquid Chromatography

目前已经鉴定的抑制分子主要有Nogo、髓磷脂相关糖蛋白及少突胶质细胞髓磷脂糖蛋白，他们通过同一受体复合体转导抑制信号。

Three major inhibitors , Nogo , myelin-associated glycoprotein and oligodendrocyte myelin glycoprotein , have been identified , which lead to signal inhibition through the same receptor complex .

方法：用激光共聚焦双重免疫荧光标记技术检测PLP在分化成熟的两型星形胶质细胞和少突胶质细胞中的表达情况。

Methods : Laser confocal double immunofluorescence staining method was used to detect the expression of PLP in the mature type-1 astrocytes , type-2 astrocytes and oligodendrocytes .

神经干细胞（NSC）是神经系统中能够自我更新并具有多向分化潜能的细胞，在一定条件下能分化为神经元、星形胶质细胞和少突胶质细胞。

Neural stem cells are the multipotential , self-renewing cells in many regions of the mammalian central nervous system . They are able to differentiate into neurons , astrocytes and oligodendrocytes under certain conditions .

成年哺乳动物脑室下区（SVZ）富有神经干细胞、神经细胞祖细胞和胶质细胞祖细胞，它们能生成新的神经细胞、星状胶质细胞和少突胶质细胞。

The subventricular zone ( SVZ ) of the adult mammalian forebrain contains stem cells , neuronal progenitors and glial progenitors which give rise to neurons , astrocytes and oligodendrocytes .

iNPC能代表前脑、中脑、腹侧大脑等区域。并且iNPC具有向神经元、星形胶质细胞及少突胶质细胞分化的潜能。

INPC could represent the forebrain , midbrain , the ventral brain areas , etc. And iNPC has the potential to differentiate into neurons , astrocytes and oligodendrocytes .

经相应特异性标志蛋白检测证实神经干细胞经诱导分化后可形成神经元（MAP2）、星形胶质细胞（GFAP）和少突胶质细胞（04）。

Staining with specific protein markers in the corresponding cells confirmed that neural stem cells could form neurons ( MAP2 ), astrocytes ( GFAP ) and oligodendrocytes ( 04 ) after differentiation induction .

研究结果表明分离后OPCs能够在体外条件下继续存活生长，保持着良好的分裂增殖能力，并且能够在体外定向分化为成熟的少突胶质细胞。

The isolated OPCs are found to be able to survive and continue to grow in vitro . These OPCs still retain the proliferative ability and further differentiate and maturate to oligodendrocytes . 3 .

其次，NSC在一定条件下能分化为三种不同神经细胞系即：神经元、星形胶质细胞和少突胶质细胞，能克服单一种类细胞移植导致局限性功能恢复的缺陷和致瘤的弊端；

The second , NSC can differentiate into three different lineages : neurons , astrocytes and oligodendrocytes under some conditions which can overcome the shortage of limited function rehabilitation caused by one lineage transplantation and the possibility to forming tumor .