大环

本品为大环内酯类抗生素。

This is the large ring lactone class antibiotic .

用手拿住探头顶部的大环。

Grasp probe by large ring at top .

四氮大环铜配合物和DNA的相互作用

Interaction between macrocyclic copper coordination compound and DNA

单N－乙酸取代N2O2大环配体及其过渡金属配合物的合成与性质的研究

Synthesis and characterization of a new mono-N-acetic acid substituted N_2O_2 macrocycle and its complexes with transition metals

两性霉素B最初是从结节性链霉菌中分离出来的一种大环内酯多烯类抗生素化合物，该化合物对真菌有较强的抑杀作用。

Amphotericin B , a polyene macrolide antibiotic , was originally isolated from Streptomyces nodosus , and it can be strong inhibiting fungus .

在小闭环内采用PID控制，大环内采用并、串复合的同步控制方法实现水压双缸同步控制。

Synchronization control was realized through the PID in inner closed loop and the series - parallel connection in outer loop .

新型大环Schiff碱化合物的合成及其晶体结构

Synthesis of Novel Schiff Base Macrocyclic Compound and Its Crystal Structure

Schiff碱大环聚醚的d过渡金属配合物的合成

The Synthesis of complexes of schiff base cyclic polyether and d-transition metal

含吡啶环的双Schiff碱大环化合物的合成与表征

The synthesis and characterization of Schiff - base type macrocycle containing pyridine ring

上述大环配体和各种配合物均经元素分析、IR、~1HNMR、MS等证实了它们的结构和组成。

All these macrocyclic compounds and complexes were identified by elemental analysis and spectral analysis ( IR , ~ 1HNMR , MS ) .

大环多胺金属配合物能水解DNA、RNA，其水解能力跟金属离子和与其连接的基团密切相关。

Metal complex of macrocyclic polyamines can hydrolyze DNA and RNA , the ability depends on metal ions and their side groups conjugated to them .

含羟基功能团Schiff碱大环聚醚化合物的合成及其结构分析

Synthesis and Structural Analysis of Schiff Base Cyclic Polyether Compound Bearing Hydroxy Functional Group

结果：急性上呼吸道感染各组首选药物为青霉素或大环内酯类，A组占82.93%，B组49.36%，C组占35%。

Result : Acute upper respiratory infections : the percentage of penicillin and macrocyclic was 82.93 % in Group A , 49.36 % in Group B and 35.00 % in Group C.

氟代喹诺酮和大环内酯抗菌剂都与QT间期的延长有关。

Fluoroquinolones and macrolide antimicrobial agents have both been associated with prolongation of the QT interval .

目的探讨大环内酯类抗生素对丙烯醛诱导的大鼠黏液高分泌模型的干预作用，以及核因子-κB（NF-κB）在黏液高分泌发病机制中的作用。

Objective To investigate the effects of macrolide on and the role of nuclear factor - κ B ( NF - κ B ) in airway mucus hypersecretion stimulated by acrolein in rats .

方法：应用微生物生长抑制原理，通过Bacillusstearothermophilus细菌的生长与否，对大环内酯类药物残留进行定性检测。

Methods : The technique was based on inhibition of growth of Bacillus stearothermophilus .

控制器采用硬件构成PI调节器和脉宽调制器，实现整个系统大环的速度闭环调节，其响应速度快，具有实时调节的优点。

PI adjuster and pulse-width modulation of the controller are constructed by hardware in order to realize the speed close-loop regulation of the whole system .

多功能臂大环多胺La（Ⅲ）配合物的合成及其对PNPP催化水解研究

Synthesis of multi-functional macrocyclic polyamines La (ⅲ) complex and its catalytic activity for hydrolysis of PNPP

方法：采用微量肉汤稀释法检测了5种大环内酯类药物对203株Uu的最低抑菌浓度（MIC）。

Methods : The MIC of five macrolides against 203 strains of Uu were determined using broth microdilution method .

结论：大环内酯类抗生素的黏液抑制性调理作用可能是由于其内在化于中性粒细胞抑制NE释放而间接实现的。

Conclusion : Suppressive effect on mucous of macrolides is indirectly realized by inhibiting NE release , dued to macrolides endocytosis in neutrophil .

阿奇霉素（Azithromycin，ATM）是新一代的大环内酯抗生素，它与传统的红霉素相比有许多优点。

Azithromycin ( ATM ) is one of the new generation of macrolides and has several advantages over traditional macrolides such as erythromycin .

耐药基因mef编码的外排蛋白是一个能量依赖的膜蛋白，由405个氨基酸组成，含12个跨膜区域，mef依靠质子运动力泵出14、15元环大环内酯类药物。

Mef pumped out 14 - and 15-membered ring macrolides by proton motility .

结论：大环内酯类药物是目前治疗Uu感染的首选药物，其次为左旋氟嗪酸和强力霉素。

Conclusion : The best antibiotic to treat Uu infection was roxithromycin , then erythromycin , levofloxacin , ofloxacin and doxycycline .

重稀土硝酸盐与单N-乙酸取代O2N2大环配合物的合成与表征

Diazo Rare-Earth Nitrates And Mono-N - Acetic Acid Take The Place of Combination And Character of O_2N_2 Great-Cycle Compound

负载有钴大环配合物Nafion膜气体扩散电极对氧的催化还原

Studies on Catalytic Reduction of Dioxygen at Gas Diffusion Electrode of Nafion Film Coated with Macrocyclic Complexes of Cobalt

从链霉菌FR－008中克隆出一个七烯大环内酯抗生素的生物合成基因簇，基因置换试验证实克隆的基因片段与抗生素生物合成直接相关。

Genes for biosynthesis of a Streptomyces sp. FR-008 heptaene macrolide antibiotic faith antifungal and mosquito larvacidal activity were cloned in E.

人CD81胞外大环在大肠杆菌中的克隆表达及活性研究

Cloning and expression of human CD81 major extracellular loop in E.coli and its activity

HPLC-ESI-MS法测定鸡肝中的大环内酯类抗生素

Determination of macrolides in chicken liver by HPLC-ESI-MS

临床治疗MP感染主要选择抑制或影响蛋白质和核酸合成的药物，如大环内酯类、四环素类、氨基糖苷类、喹诺酮类。

Antibiotics which can affect the protein and nucleic acid synthesis , including macrolide , quinolone , aminoglycosides , and tetracycline , were effective for the therapy for MP infection .

头孢菌素类占抗菌药物DDDs最高为45.6%，其次是大环内酯类为33.7%，青霉素类为13.5%。

Cephalosporin medicines took up 45.6 % of anti-infection agents DDDs ; next , Macrolide medicines 33.7 % , Penicillium medicine 13.5 % .