吡嗪

因此，Fe3+可能是与主体8中的吡嗪N结合。

Therefore , Fe3 + may be combined with the N of pyrazine .

给、吸电子基团对吡嗪衍生物电子结构影响的DFT研究

DFT study on Electronic structures of pyrazine derivatives with donor and acceptor group

血浆中格列吡嗪的HPLC测定

HPLC determination of glipizide in plasma

方法：TLC法按中国药典2000年版格列吡嗪片有关物质检查薄层色谱条件；

Methods : The TLC was concordant with the method described in Chinese Pharmacopoeia 2000 ;

四甲基吡嗪对肝纤维化大鼠肝组织中肌细胞增强因子2A表达的影响

Effects of tetramethylpyrazine on expression of myocyte enhancer factor-2A in rats with liver fibrosis

四甲基吡嗪衍生物合成及其5-HT3受体拮抗活性的筛选

Synthesis of the Derivatives of Tetramethylpyrazine and Screening for 5 - HT _ 3 Receptor Antagonistic Activity

该反应产物的醚溶性成分经GC／MS分析显示，其主要成分为吡嗪类和呋喃类化合物。

The ether soluble compounds of the reaction product were analyzed by GC / MS. The major iden tified compounds were pyrazine and furan compounds .

本实验采用GC/MS法对镇江香醋中的川芎嗪（即四甲基吡嗪）成分进行定性鉴定，采用反相HPLC测定含量。

Tetramethylpyrazine was determined by GC / MS in the famous Chinese vinegar , Zhenjiang Vinegar . RP & HPLC was used to determine the quantity .

结果格列吡嗪控释片每日服用1次的降糖效果与格列吡嗪速释片每日服用3次的降糖效果相同，控释片组胰岛素和C肽水平较低。

Results controlled-release formula of glipizide once daily and immediate release glipizide 3 times per day showed a similar effect on glucose level , but the former did not increase insulin and C-peptide level .

HPLC-MS研究格列吡嗪片人体药动学和生物等效性

Study on Pharmacokinetics and Bioequivalence of Glipizide Tablets by HPLC-MS in Healthy Volunteers

观察了四甲基吡嗪（TMP）对LDL损伤内皮细胞（EC）的保护作用。

ABSTRACT Effects of tetramethylpyrazine ( TMP ) on endothelial cells damaged by low-density lipoproteins ( LDL ) were investigated .

Maillard反应中吡嗪形成的研究

Study of Pyrazines Formation in Maillard Reaction

结果2型糖尿病患者血浆脂过氧化物水平和TNFα水平高于对照组，格列吡嗪控释片能使之降低至对照组相似的水平。

Results Plasma lipid peroxide and tumor necrosis factor alpha levels were enhanced in type 2 diabetes mellitus patients , and glipizide GITS administration totally reversed these abnormalities .

SDE法可得到大量的吡咯、吡嗪类化合物。

A lot of pyrazines , pyrroles , furans were obtained by SDE .

HPLC-MS测定人血浆中格列吡嗪及其药动学研究

Determination of Glipizide in Plasma by HPLC-MS and Study on Its Pharmacokinetics in Healthy Subjects

氧甲吡嗪在糖尿病患者~（18）F-FDG心肌代谢显像中的作用

Feasibility of ~ ( 18 ) F-FDG myocardial metabolism imaging following oral acipimox in patients with diabetes mellitus

结论格列吡嗪（2.95±0.6）h血药浓度达高峰，峰浓度为（456±60）ng／ml。

Conclusion The plasma concentration of glipizide capsule attach peak in ( 2.95 ± 0 . 6 ) h , its peak concentration is ( 456 ± 60 ) ng / ml.

目的探讨临床常用的口服降糖药物格列吡嗪及二甲双胍和对Ⅱ型糖尿病人血清胰岛素样生长因子1,2（IGF1,2）的影响。

Aim To study the effects of glipizide and metformin on the serum IGF_1 , IGF_2 in patients with type ⅱ diabetes mellitus ;

吡嗪酰胺（PZA）是结核病短程化疗中的一线抗结核药物，由吡嗪酰胺酶转换成为活性形式吡嗪酸而生效。

Pyrazinamide ( PZA ) is an important component in short-course tuberculosis chemotherapy .

研究了羟丙甲纤维素（HPMC）水凝胶型格列吡嗪缓释片的制备及其释药特性。

Glipizide hydrophilic gel tablets containing hydroxypropylmethyl-cellulos ( HPMC ) were prepared , and their drug release characteristic was also evaluated .

计算结果表明：三种化合物分子内部HOMO到LU-MO电子跃迁，哒嗪的电子是由杂原子N向C原子转移，而吡嗪和嘧啶电子转移方向刚好相反；

The results show that the transition between HOMO and LUMO in the three compounds is the electronic transformation from hetero-atoms N to C in pyridazine while from C to N in pyrazine and pyrimidine .

采用川芎嗪的提取物-四甲基吡嗪作为金属管状支架的涂层制成川芎嗪涂层冠脉支架（TES），利用局部缓释技术抑制支架内再狭窄。

Tetramethylpyrazine - eluting stent ( TES ) is made up of bare-metal stent coating with Tetramethylpyrazine ( TMP ) .

底物为2,6-二氯吡嗪（4a）的Suzuki偶联反应产率较低，该优化条件对之兼容性较差。

Substrate for the 2,6-dichloro-pyrazine ( 4a ) of the low yield SUZUKI coupling reaction , the optimal conditions for the compatibility is poor .

通过对格列吡嗪胶囊溶出度两种测定方法比较表明：HPLC法和UV法测定其溶出度结果：两者相差约10%，应以HPLC法测定为好。

Through the comparison between two methods for determination the dissolution of Glipizide Capsules , the results showed : that HPLC method was better than UV method , and the variance . between two methods was about 10 %

目的探讨格列吡嗪治疗对2型糖尿病病人血清胰岛素样生长因子（IGF）及其结合蛋白（IGFBP）的影响。

Objectives To study the effects of glipizide on the serum IGF-1 , IGF-2 , IGFBP-1 and IGFBP-3 in patients with type 2 diabetes mellitus .

研究了各种有机溶剂对Eu3＋，Tb3＋－吡嗪－2，3－羧酸荧光体系的增敏效应。

The sensitivity-increasing effect of various organic solvents on Eu3 + , Tb3 + - pyrazine-2 , 3-carboxylic acid fluorescence system is studied .

方法单剂量给予国产的复方格列吡嗪片505mg（试验制剂）和格列吡嗪片5mg（参比制剂）、盐酸二甲双胍片500mg（参比制剂）。

Methods A single oral dose ( 5 mg of Glipizide and 500 mg of Metformin hydrochloride ) was given to volunteers .

糖尿病组予格列吡嗪控释片5～10mg，每日1次，早餐前服用，疗程4wk。

Patients in diabetes group received glipizide extended release 5-10 mg , qd , for 4 wk .

方法以2-吡咯甲酸甲酯为原料，经取代、环合，制备（2H）-2-环己基-3,4-二氢吡咯[1,2-a]吡嗪-1-酮（3）；通过Friedel-Crafts酰基化反应，制得其6-酰基衍生物4a~4j。

Method ( 2H ) - 2-cyclohexyl-3,4-dihydropyrrolo [ 1,2-a ] pyrazin-1-one was synthesized from methyl pyrrole-2-carboxylate via substitution and cyclization , and the target compounds 6-aryl derivatives were obtained by Friedel-Crafts reaction .

吡嗪类化合物由美拉德反应生成，炒籽30min后温度攀升为反应提供了良好的反应条件。

Pyrazine compounds generated by the Maillard reaction and the sharp temperature rise after 30 min-roasting provided a well reaction condition for the Maillard reaction .