刺激分化

方法：以佛波酯刺激分化的THP-1细胞作为单核细胞来源巨噬细胞模型。

Method : We used PMA-treated THP-1 cells as a model of monocyte-derived macrophages .

Thl、Th2细胞的分化方向及分泌功能已逐步被人了解，但其刺激分化的分子机制尚未完全清楚。

Th1 、 Th2cells ' differentiation and secretory function has gradually been understood but stimulating the differentiation of the molecular mechanisms are not yet fully clear .

结论淫羊藿甙不仅能促进成骨细胞的分化，还能增强其增殖能力，而葛根素主要是通过刺激分化来增强成骨细胞的活力。

Conclusion Icariine has the effect of increasing the proliferation and differentiation of osteoblasts while Puerarin mainly stimulates the differentiation of osteoblasts .

依靠蛋白质的作用，靶细胞被刺激分化，通过自分泌或旁分泌的方式促进成骨。

Depend on the role of proteins , target cells were stimulated differentiation by an autocrine or paracrine manner to promote osteogenesis .

CSF可诱导人破骨细胞形成，刺激其分化、存活，参与成熟破骨细胞对骨的吸收作用；

M-CSF can induce human osteoclast formation and stimulate them to differentiate , survive and participate bone resorption caused by mature osteoclasts , and inhibit the apoptosis of osteoclasts .

维甲酸、去甲基化及组蛋白脱乙酰酶抑制剂可刺激失分化甲状腺癌细胞的NIS表达，为甲状腺癌131I的有效治疗进行了有益的探索。

Retinoic acide and demethylation as well as histone deacetylase inhibitors treatment , have been explored with the aim of stimulating NIS expression and optimizing therapeutic responsiveness to 131I in thyroid cancer .

外周免疫器官中淋巴细胞由中枢免疫器官迁移而来，经抗原刺激而分化增殖，继而产生免疫学功能。

Lymphocytes in peripheral immune organs immigrate from center immune organ . These lymphocytes can proliferate and generate immunological function stimulated by antigens .

MBL对LPS刺激的不同分化和活化状态THP1/CD14细胞产生TNF-α和IL-12的影响

Effects of mannan-binding lectin on TNF - α and IL-12 production induced by lipopolysaccharide in differentiated and activated THP1 / CD14 cells

结论：人脐血CD34+细胞在体外培养条件下经过IL-5和病人血清刺激可早期分化为嗜酸粒细胞。可作为有效的相关研究模型。

CONCLUSION : The allergic patient serum and IL-5 induce differentiation of CD34 ~ + cells in human umbilical blood to eosinophils .

由此得出结论：外周血中确实存在EPCs，并且在血管生长因子VEGF、bFGF、IGF、EGF等的刺激下能分化为成熟的Ecs。

In conclusion : EPCs exist in the peripheral blood , and can be differentiated into mature ECs by the stimulation of VEGF , bFGF , IGF and EGF .

目的探讨甘露聚糖结合凝集素（MBL）对脂多糖（LPS）刺激的不同分化和活化状态THP1/CD14细胞产生TNF-α和IL-12的影响。

Objective To investigate the effects of mannan-binding lectin ( MBL ) on TNF - α and IL-12 production induced by lipopolysaccharide ( LPS ) in differentiated and activated THP1 / CD14 cells .

许多微流控细胞阵列已经被用于研究包内酶活性、化学浓度梯度对细胞的刺激、细胞分化、基因表达的动力学特征和高通量药物筛选，且都在纳升或皮升级下进行。

Many microfluidic devices have been developed for cell culture and to study intracellular enzyme activities , cellular responses to chemical gradients , cellular differentiation , dynamic gene expression and cell cytotoxicity screening .

在早期，它因能刺激骨细胞分化而引起关注；近年来发现它在与牙齿发育有关的原始口腔上皮中有表达。

In the early days , it caused for concern because the ability to stimulate bone cell differentiation ; in recent years , it had been founded in the expression of tooth development related in original oral epithelium .

IL-6能刺激B细胞增殖分化，并诱导成熟B细胞分泌抗体。

IL-6 could stimulate the proliferation and differentiation of B cells , and induce B cells to excrete antibodies .

MEK作为共刺激因子对DC分化成熟的影响及其疫苗对Lewis肺癌抑瘤作用的研究

Studies on the Role of MEK as a Costimulating Factor in DC Maturation and MEK-DC Vaccine in Inhibiting Lewis Lung Carcinoma

野生型的WT1转染髓系祖细胞后，可使细胞失去受粒细胞集落刺激因子的诱导分化，而代之以持续增殖。

Constitutive WT1 expression in myeloid progenitor cells by the transfection of the wild-type WT1 gene promoted their proliferative response to G-CSF , but inhibited their differentiation .

PUPS能刺激巨噬细胞进步的分化成熟而成为活化巨噬细胞，从而增加小鼠腹腔巨噬细胞的吞噬功能以及能量代谢水平。

PUPS can stimulate macrophages further differentiation of mature and become activated macrophages , thereby increasing the mouse peritoneal macrophage phagocytic function and energy metabolism . 2 .

CD40配体（CD40L）是一种免疫调节分子，CD40L与CD40结合能有效刺激T细胞增殖分化，增强其特异性杀伤肿瘤细胞的作用，还可诱导T细胞分泌细胞因子，从而发挥抗肿瘤作用。

CD40 ligand is one of the immunological regulatory molecules , and the interaction of CD40 and CD40 ligand ( CD40L ) can induce the proliferation and the differentiation of T-cell , which can further activate the specific cytotoxic effects on tumor cells and induce the production of the cytokines .

细胞学研究发现，随年龄增大骨髓基质干细胞的数量减少，骨髓基质干细胞在骨折环境的刺激下可能会分化为脂肪细胞而不是成骨细胞，同时这些干细胞的传代能力减弱。

At the cytology level , the number of MSCs decrease as age advancing , and these MSCs differentiate to lipocyte instead of osteoblast when stimulated by the environment changes .

具有选择性刺激定向千细胞分化生成中性粒细胞集落的功能，并且对某些白血病细胞的分化和增殖有影响。

G-CSF possesses the ability to stimulate the colony formation of granulocyte from committed hematopoietic stem cells . It may exert effects on possible proliferation and differentiation of some human and murine myeloid leukemic cells .

结论：1,25（OH）2D3有促进人牙乳头细胞矿化作用，表现在不仅能刺激OC、ALP的活性，而且可刺激具有分化表型的牙乳头细胞中CaB的合成，增加基质对Ca2+的摄取。

CONCLUSION : These findings indicated that the 1,25 ( OH ) 2D 3 can stimulate mineralization process of the mesenchymal cells , which is manifested in promoting ALP activity , OC content , CaB synthesis and calcium uptake by the differentiated cells .