免疫耐受性

另外，由Fas/FasL系统介导的细胞凋亡可能与母体对胎儿的免疫耐受性有关。

Apoptosis mediated by Fas / FasL system may also be associated with maternal immunotolerance to the fetus .

目的：探讨胎鼠、新生鼠供体的免疫原性及新生鼠、成年鼠的免疫耐受性，建立延长移植组织存活时间的方法。

Aim : To explore the immunogenicity of the fetal and the newborn donor rat adrenal tissue as well as the immunotolerance of the newborn and the adult rat as recipients .

通过过继转移免疫耐受性DC，可明显降低糖尿病高血糖以及小鼠脾淋巴细胞增殖能力，与模型对照组差异有统计学意义（P＜0.01）；

Both of the high level blood glucose and T cell proliferation were decreased significantly by adoptive transfer of tolerogenic DC ( P < 0.01 );

结论长期注射大剂量同种异体AKautoAb的家兔可产生免疫耐受性。

Conclusion Rabbits could be induced to form immune tolerance when high-does allogenic AK auto Ab is administrated for long-term .

去脑垂体大鼠诱导免疫耐受性的实验研究

Experimental Study on the Induction of Donor-Specific Tolerance in Hypophysectomized Rats

日本血吸虫病经胎盘传播免疫耐受性的进一步研究

The further research of immunologic tolerance of congenital transmission of schistosomiasis

免疫耐受性树突状细胞在移植免疫中的作用及其分子机制

Roles and mechanism of tolerogenic dendritic cells in transplantation immunity

目的进一步探索日本血吸虫病经胎盘传播的免疫耐受性。

Aim To explore the immunologic tolerance in congenital transmission of Schistosoma japonicum .

用固相抗体-抗原复合物逆转对鸭乙型肝炎病毒的免疫耐受性

Solid matrix antibody antigen ( smaa ) complex can revert immune tolerance versus duck hepatitis B virus infection

经统计学分析，转基因鼠的抗体水平变化相差不显著，表明转基因小鼠对该病毒形成了部分免疫耐受性。

No one produced significant antibody response against the virus , indicating that the transgenic mice have developed immune tolerance to rabies virus .

但是，为了确定该研究发现的这些生物标志物是否能可靠预测免疫耐受性，还需要进行大规模前瞻性研究。

However , large , prospective studies will be necessary to determine if the same biomarkers identified in the current study are reliable predictors of immune tolerance .

结论哮喘患儿对标准化屋尘螨提取液特异性免疫治疗耐受性良好，绝大多数局部不良反应为轻度，全身不良反应均为轻度，经及时调整剂量递增方案，可减少可控性不良反应的发生。

Conclusion Subcutaneous SIT with standardized house-dust mite extract show a good tolerance in asthmatic children . A majority of local reactions and all systemic reactions are mild and respond well to ordinary treatment and adjustment of dose-increase schedule .

炎症性肠病动物模型的建立及外源性IL-10和益生菌诱导粘膜免疫耐受治疗炎症性肠病的效应探讨

Investigation on the Construction of Animal Model of Inflammatory Bowel Disease and the Therapeutic Efficacy of Mucosal Tolerance Induced by IL-10 and Probiotic

口服滋养细胞抗原诱导免疫耐受的实验性研究

Experimental Study on Immune Tolerance Induced by Trophoblast Antigens

尘螨变应性哮喘患儿对标准化螨提取液特异性免疫治疗的耐受性及依从性

Tolerance and Compliance of Asthmatic Children for Specific Immunotherapy with Standardized House-Dust Mite Extract Therapy

白血病细胞对化疗药物产生耐受的同时也产生了对免疫细胞的耐受性，从而直接影响免疫治疗疗效。

Leukemia cells which produce the tolerance to chemotherapy drug and to immune cells directly affect the effect of immunotherapy .

近年更多的研究表明，DC在外周免疫耐受中起关键性作用。

Recently investigations indicated that DCs play a critical role in the peripheral tolerance .

结果提示口服CⅡ诱导免疫耐受、治疗类风湿性关节炎可能与CⅡ特性和胰蛋白酶对其的作用有关。

The results suggest that the inducing immunotolerance to treat RA by oral administration of C ⅱ is possibly concerned with the C ⅱ characteristics and trypsin enzymolysis .

抗CD4单抗诱导免疫耐受防治自身免疫性心肌炎的研究

Monoclonal anti-CD4 prevents the development of experimental autoimmune myocarditis by inducing immune tolerance to cardiac myosin

血清特异性抗体的水平和细胞因子表达的变化的结果表明，口服CⅡ有助于诱导免疫耐受并干预类风湿性关节炎的发生发展，有着潜在的类风湿性关节炎防治作用。

The results on the changes of serum specific antibodies and cytokine gene expressions indicate that the oral C ⅱ will help to induce immune tolerance , interfere in the RA development and progression and has some potential preventive and therapeutic effect .

结论成功构建了hPD1Fc重组表达载体，利用哺乳动物细胞CHO表达出有活性的hPD1Fc融合蛋白，为进一步研究PD1分子在免疫耐受、自身免疫性疾病中的作用奠定了基础。

Conclusion The hPD-1-Fc chimeric molecule is constructed and expressed successfully , which provides base for further investigation of the role of PD-1 in immune tolerance and autoimmune disease .

该方法诱导的移植免疫耐受具有供体特异性。

It has donor specificity in transplant immunotolerance by this method .

诱导实验性自身免疫性重症肌无力耐受性的机制初步探讨

A preliminary study of the mechanisms of immune tolerance to experimental autoimmune myasthenia gravis

口服免疫耐受与眼部免疫性疾病的治疗

Immunologic tolerance and treatment of ocular immunologic diseases

近年来通过口服抗原（耐受原）诱导免疫耐受，靶向性治疗自身免疫病的研究日益受到关注。

The therapy of autoimmune diseases by inducing oral immune tolerance has progressed a lot recently .

肝细胞移植可以明显延长移植胰岛细胞的功能存活期，并诱导受者产生特异性免疫耐受和非特异性免疫抑制。

Hepatocyte grafting can prolong the survival time of transplanted pancreatic islets , and can induce the nonspecific immunosuppression and specific immunosuppression of recipient rats .

结论T细胞疫苗可以诱导同种抗原特异性免疫耐受，CD4~+反应性T细胞克隆与CD8~+抗独特型T细胞克隆相对比例优势的转换可能在T细胞疫苗诱导的免疫耐受形成中发挥关键作用。

Conclusion T cell vaccination can induce specific immune tolerance , clone transforming from CD4 + T cells to CD8 + T cells may be critical in inducing specific immune tolerance .

目的探讨体内注射CD4单克隆抗体诱导大鼠对猪心肌肌凝蛋白产生免疫耐受及这种免疫耐受对自身免疫性心肌炎大鼠的治疗作用。

Objective To investigate whether monoclonal anti-CD4 can induce immune tolerance to por - cine cardiac myosin and whether the immune tolerance can protect rats with autoimmune myocarditis from cardiac dysfunction and myocardial injury .

结论先天性感染日本血吸虫的仔兔血清抗体呈低免疫反应状态（hypo-responsiveness），可能存在免疫耐受，攻击性感染不能诱导仔兔免疫系统产生明显的保护性免疫。

Conclusion Congenital infection of Schistosoma japonicum might decrease the immune response of kittens to re-exposure to Schistosoma japonicum ( hypo-responsiveness ), which might be indicative of immunologic tolerance . Challenging infection can 't induce significant protective immunity in kittens with congenital infection .

它们在天然免疫中可发挥重要的抗感染免疫功能，并与免疫耐受、特异性抗感染免疫，以及一些疾病具有相关性。

They are crucial participants in the innate immune responses , and are closely related to immunologic tolerance , specific anti-infective immunity and some other diseases .