体细胞突变

肿瘤发生的遗传机制；体细胞突变的发生机制；DNA修复，基因组学与分子医学。

Cancer genetics , somatic mutagenesis , DNA repair , genomics and molecular medicine .

目的制备抗GPA单克隆抗体以建立“GPA体细胞突变分析法”。

Objective To prepare anti GPA McAb for establishing GPA somatic mutation assay .

SLE病人遗传学的研究发现抗dsDNA自身抗体大多属于对dsDNA具有高亲和力的IgG亚类，不同于体细胞突变产生的抗体。研究显示自身DNA可以诱导抗dsDNA抗体产生。

Genetic studies in SLE patients revealed that anti-dsDNA autoantibodies , which generally belong to IgG subtype with high-affinity binding to dsDNA , differ from the germ line due to somatic mutations .

方法采用体外蛋白合成试验和序列分析确定19例HNPCC病例APC体细胞突变。

Methods PCR based in vitro synthesized protein test ( IVSP ) assay and sequencing analysis were used to confirm somatic mutations of whole APC gene in 19 HNPCC patients .

结果发现4例体细胞突变均有临床效应；

Results : Observation 4 cases with somatic mutation have clinical effect .

癌基因组不稳定性来源于胚系突变和体细胞突变。

The genomic instability of cancer stems from germ-line mutation and somatic mutation .

细胞工程育种&林木耐盐体细胞突变体育种研究进展

Progress in the Breeding of Saline-tolerant Somatic Mutant Trees AN APPROACH TO ECOSYSTEM ENGINEERING

种子繁殖和体细胞突变是芦苇种群遗传多样性产生的主要途径，杂合子的选择优势可能是遗传多样性维持的重要机制之一。

The selection advantage of heterozygotes maybe is the important mechanism of maintaining genetic diversity .

肝癌患者β-catenin基因第三外显子的体细胞突变

Somatic mutations on exon 3 of the β - catenin gene in human hepatocellular carcinoma

基因组不稳定性与癌的遗传易感性相关，涉及基因组结构改变和表遗传效应，来源于胚系突变和体细胞突变。

Genomic instability involving structure alterations and epigenetic effect stems from germline and somatic mutation and related to genetic susceptibility of cancer .

体细胞突变是柑橘等果树比较常见的生物学现象，也是品种选育，即芽变选种的主要变异来源。

Somatic mutation , a main biological phenomenon of citrus and other fruits , is often used for breeding as a major variation source .

例如，植物有时将体细胞突变通过无性或有性过程传递给后代，而花芽可能由植物的体细胞变异部分发育。

For example , plants can sometimes transmit somatic mutations to their descendants asexually or sexually where flower buds develop in somatically mutated parts of plants .

在M1所产生的叶绿素缺失中，大多数属于体细胞突变，或是由于辐射损伤所致，一般是不能遗传的；

Most of the chlorophyll deletion occurred in M1 were belonged to somatic mutation or caused by radiation injury so that they usually were not inheritable .

在这里，我们调查的，是由体细胞突变引起的肿瘤细胞的细胞核，能被后生重编程进入正常组织的可能性。

Here , we investigate the possibility of whether a tumor cell nucleus , in which transformation is caused by somatic mutation , can be epigenetically reprogrammed into normal tissues .

体细胞超突变与B细胞淋巴瘤

Relationship between somatic hyper mutation and the pathogenesis of B cell lymphoma

肿瘤通常是指机体在各种致癌因素作用下，由于某些特定染色体上的DNA损伤引起体细胞发生突变而导致其克隆性异常增生形成的新生物。

The body always is affected by all kinds of carcinogenic factors that lead to tumor development . Tumor is a neoplasm which forms under some DNA impairment in definite chromosome that causes somatic cell mutation and clonally abnormality hyperplasia .

4个新的体细胞性突变中2个为错义突变。

There were two missense mutations in four novel somatic mutations .

目的探讨乳腺癌的线粒体基因D环区的体细胞性突变和多态性变异特征。

Objective To investigate the features of somatic mutations and polymorphisms of mitochondrial D loop regions in breast cancer .

肿瘤的发生经历正常体细胞的突变、免疫系统对突变细胞的识别及免疫系统对肿瘤细胞的杀伤作用等三个阶段。

There are three steps in the development of cancer including mutation of normal cells , recognition and killing against cancer cells by the immune system .

子宫肌瘤发生可能涉及正常子宫肌层体细胞的突变，性激素及生长因子间复杂的相互作用，氧化应激，细胞周期的异常及炎症。

Normal myometrium somatic mutations , the interaction between sex hormones and growth factors , oxidative stress , dysregulation of cell cycle and inflammation have been reported to be associated with the growth of leiomyomas .

体细胞HPRT基因突变检测用于辐射剂量估算的可行性研究

Feasibility study of radiation dose estimation using somatic HPRT gene mutation

克隆法检测大鼠体细胞HPRT基因突变探讨

Discussion on Cloning Method for Detecting the HPRT Gene Mutation of Rats

目的克隆法研究放射性核素内照射诱发大鼠体细胞HPRT基因突变，比较不同体细胞HPRT基因突变频率。

Objective To study and compare the HPRT gene mutation in rat soma cells induced by internal exposure to radionuclides using cloning method .

多核细胞法和Brdurd法检测辐射诱发体细胞HPRT基因突变的比较研究

Comparative Study on Multinucleated Cell Assay and Brdurd Labeling in Detecting the Somatic HPRT Gene Mutation Induced by Radiation

方法应用人外周血淋巴细胞抗6－TG分析技术检测了30例健康成人和30例放射工作者体细胞HPRT位点突变频率。

Methods Mutant frequencies of somatic HPRT locus in peripheral blood lymphocytes of 30 healthy adults and 30 radiation workers were detected by using 6 thioguanine resistant ( TG r ) assay .

2000ppm染毒时胎肝血嗜多染红细胞微核出现率显著高于阴性对照组，这表明苯经胎盘转运至胎体后对胎仔体细胞有致突变作用。

The occurence of exposed micronucleus , 2000 ppm is apparently higher than that in control group . This suggests that concentrative benzene is able to poison the mice foetus and cause injuries in the chromosome in cells .

目的探讨克隆法检测大鼠体细胞HPRT基因突变，为后续研究打下基础。

Objective To discuss the cloning method for detecting the HPRT gene mutation of rats .

健康成人和放射工作者体细胞HPRT基因位点突变率的检测和比较

Detection and comparison of mutant frequency of somatic HPRT locus between healthy adults and radiation workers

晚期混合裂变产物内照射诱发体细胞HPRT基因位点突变率与剂量率关系的研究

Study on the relationship between dose-rates and somatic cell mutation at HPRT locus induced by late fission products

能源循环释放的辐射和化学污染物致体细胞HGPRT基因位点突变的比较研究

Comparison of somatic mutation frequencies at HGPRT locus induced by radiation and chemical pollutant from energy system