乙酰化

Western印迹法检测处理后膀胱癌细胞组蛋白乙酰化水平的变化；

The acetyl level of histone after TSA treatment was detected by Western blot ;

N4-乙酰化代谢是本药的主要消除方式，所给剂量62.1%以该方式消除。

The 62.1 percent of the administered dose was metabolized by N4-acetylation in the body .

用咖啡因作代谢探针测定研究了203例健康志愿者的N－乙酰化表型。

Acetylator status in 203 healthy Chinese volunteers was determined with caffeine as a probe drug .

靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。

Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials .

目的DNA甲基化和组蛋白乙酰化是基因表达调控的主要形式。

Objective DNA methylation and chromatin modification of histone acetylation are two global mechanisms that regulate gene expression .

ELISA法测定人血中单核细胞乙酰化低密度脂蛋白受体活性

Determination of AcLDL Receptor Activity of Human Monocyte by ELISA

样品经索氏提取器提取后，再以咖啡因-甲酸提取液提取，经乙酰化滤纸纸层析分离，用荧光薄层扫描法测定各样品中B（a）P的含量。

After combining extraction by caffeine and formic acid with PC-Scanning method , the B ( a ) P contents were obtained .

真核细胞组蛋白N端赖氨酸残基的乙酰化与基因的转录激活有关。

Acetylation of lysine residues of core histone N terminal domains has been found correlatively associated with transcriptional activation in eukaryotes .

通过WESTERNBLOTTING方法检测组蛋白H3乙酰化水平的改变。

The level of acetylated histone H3 was detected by Western blotting .

以咖啡因为代谢探针，对203例中国健康志愿者和67例膀胱癌患者的N－乙酰化代谢表型进行了对比研究。

Acetylator status of 203 healthy Chinese volunteers and 67 patient with urinary bladder cancer were determined with caffeine as a probe drug .

壳聚糖（chitosan，CS），是一种天然阳离子多糖，是甲壳素脱乙酰化的产物。

Chitosan , a cationic polysaccharide in neutral , is obtained from the deacetylation of chitin .

目前发现有如下几种表观遗传分子机制：DNA甲基化，RNA干扰，组蛋白乙酰化和组蛋白修饰。

There are several types of epigenetic inheritance systems methylation of DNA , RNA interference , histone acetylation and protein modification .

其他的工作集中在组蛋白乙酰化，这种化学修饰可以使DNA从组蛋白缠绕中解离出来，产生基因活性。

Other work has focused on histone acetylation , a chemical modification that unwinds DNA from protein spools called histones , thereby enabling gene activity .

GP的乙酰化和酶活受细胞内能量状态的调控。

Cell energy status can regulates the acetylation and activity of GP .

目的分析和探讨同一结肠癌细胞系DNA甲基化和组蛋白乙酰化对抑癌基因表达和细胞周期的影响。

Objective To investigate the effects of DNA methylation and histone acetylation on cell cycle progression and expression of tumor suppressor genes in human colonic cancer cells .

曲古菌素A对HL-60细胞组蛋白乙酰化水平和凋亡的作用

Effect of Trichostatin A on Histone Acetylation Level and Apoptosis in HL-60 Cells

部分乙酰化聚乙烯醇的FTIR研究&谱图分析程序的应用

FTIR STUDIES OF PARTIALLY ACETYLATED POLY - ( VINYL ALCOHOL ) & Application of Spectra Analyzing Programm

能明显上调组蛋白H3的乙酰化水平，促进P53的表达和P53的乙酰化。

The levels of histone H3 acetylation , P53 expression and P53 acetylation were increased obviously .

大脑皮层和海马部位的胆碱乙酰化转移酶（ChAT）活性显著低下；

Neurochemical study showed that choline acetyltransferase ( ChAT ) activity in the cerebral cortex and hippocampus decreased significantly ;

姜黄素诱导Raji、HL-60和K562组蛋白乙酰化的研究

Curcumin causes histone acetylation enhancement in Raji , HL-60 and K562 cell lines

这些结果显示，即使组蛋白去乙酰化酶可以作为治疗AD的潜在靶点，但是持续的用药还是必需的。

These results indicate that although histone deacetylase can be served as a potential target for treating AD , continuous drug administration may be required .

p53去乙酰化是与乙酰化相反的过程，由组氨酸去乙酰化酶介导。

Deacetylation of p53 is the contrary process of acetylation of p53 , which is mediated by histone deacetylase ( HDACs ) .

二妙丸类方抗湿热证痛风有效部位群乙酰化GC指纹图谱比较研究

A Comparative Study of GC Acetyled Fingerprint and Effective Parts of Ermiao Wan Categorized Formula in Anti-Gouty Syndrome of Damp and Heat

研究表明，组蛋白的乙酰化与去乙酰化状态，可作用于T、B细胞的发育、分化、成熟、分泌及表面因子的表达等多个方面。

Studies had shown that acetylation and deacetylation of histone are of certain value on T , B cell 's development , differentiation , maturation , secretion and surface factor 's expression etc.

我们认为姜黄素的抗肿瘤作用，与其HAT抑制活性及对组蛋白乙酰化的诱导作用关系不大。

We believe that the effect of HAT inhibition and induction of histone hyperacetylation of curcumin plays little role in its anti-cancer effect .

方法：构建c-fos启动区氯霉素乙酰化转移酶（chloramphenicolacetyl-transferase，CAT），然后转染HeLa癌细胞株，用不同浓度SeO2处理后观察细胞中CAT的活性。

METHODS : HeLa cells were transfected with plasmids containing upstream regulating regions of c fos chloramphenicol acetyl transferase ( CAT ) .

乙酰化EGCG衍生物的合成、纯化及应用特性研究

Studies on the Synthesis , Purification and Application Characterization of Acetylated EGCG Derivatives

叶酸靶向的PGA联合N-苯乙酰化阿霉素的抗肿瘤活性

Anticancer activity of N - ( phenylacetyl ) doxorubicin combined with folate - targeted PGA

宫内生长受限大鼠肝脏组蛋白H3乙酰化的研究

Acetylation of hepatic histone H3 in rats with intrauterine growth retardation

去甲基化和组蛋白去乙酰化转移酶抑制剂对K562细胞增殖和肿瘤相关基因表达的影响

Effect of Inhibitors for Demethylation and Histone Deacetylase on Proliferation of Cell Line K562 and Expression of Tumor Related Genes