脱氧鸟苷

DNA加合物8-羟基脱氧鸟苷特性研究

Characteristic Study of DNA Adduct 8 - Hydroxy - 2 - Deoxyguanosine

目的探讨老龄大鼠大脑皮质基因组DNA中8羟基2′脱氧鸟苷（8OHdG）变化规律和左归丸的调节作用。

Purpose To explore the altered concentrations of 8 hydroxy 2 ′ deoxyguanosine ( 8 ? OH dG ) in cerebral genome of aging rats and regulative effect of Zuogui Wan ( ZGW ) on it .

石棉纤维诱发8－羟脱氧鸟苷导致DNA损伤的体外研究

A Study of DNA Damage Induced by Asbestos Fibers in Vitro

肝脑型线粒体DNA缺失综合征的新脱氧鸟苷激酶基因突变

New DGK gene mutations in the hepatocerebral form of mitochondrial DNA depletion syndrome

DNA主链构象与脱氧鸟苷组分构象相关性的喇曼分析

Raman Spectroscopic Analyses of Conformations Relationship Between Deoxyguanosine Component and Deoxyribose - phosphate Backbone in DNA

8-羟基脱氧鸟苷是DNA损伤生物标志物中最有代表性的一种。

8-Hydroxy-2 ' - deoxyguanosine is one of the most representative biomarkers of oxidative DNA damage .

ELISA方法测定尿8-羟基脱氧鸟苷（8-OH-dG）含量及其临床意义

Determination of urine 8 - hydroxyl - deoxyguanosine using ELISA method and its clinical significance

目的探讨8羟基脱氧鸟苷（8OHdG）在肺癌发生中的作用及其分子机制。

Objective To investigate the role of 8-hydroxydeoxyguanine ( 8-OH-dG ) in the development of human lung cancer and its molecular mechanism of carcinogenesis .

应用高效液相色谱电化学检测技术，以及单细胞凝胶电泳技术，研究了11种不同价态金属离子体外诱导核酸（DNA）氧化损伤产生8羟基脱氧鸟苷和DNA链断裂的化学机制。

The oxidative DNA damage markers - 8-hydroxy-2 ' - deoxyguanosine and DNA strand breakage , induced by reactive oxygen species due to metal ions in vitro , were observed using high performance liquid chromatograph coupled with electrochemical detection and single cell gel electrophoresis .

然后，按照固相亚磷酰胺化学法的要求，将修饰后的脱氧鸟苷进行N2位的碱基保护，以及脱氧核糖上的羟基保护，合成得到DNA单体。

Then we modified the deoxyguanosine derivative according to solid-phase phosphoramidite method , which should protect N2 position on the base , as well as protect the hydroxyl groups on the deoxyribose with certain bases , and got the DNA monomer .

因此，我们致力于将光敏性基团（即反式苯乙烯），修饰于脱氧鸟苷的C-8位，合成得到DNA单体。

In this paper , we have devoted our efforts to modify 2 ' - deoxyguanosine at C-8 with photosensitive group (( E ) - styryl ) to get the desired DNA monomer .

应用液相色谱-电化学法研究丙烯醛致DNA分子产生氧化损伤标志物8-羟基脱氧鸟苷（8-OHdG）。

The oxidative DNA damage marker , 8 , hydroxy , 2 ' , deoxyguanosine ( 8 , OHdG ), was detected by high performance liquid chromatography with electrochemical detection ( HPLC , EC ) .

本研究旨在探讨ref1在肺癌中的表达及其与氧化损伤标志8羟基脱氧鸟苷（8OHdG）的关系。

We investigated the expression of ref-1 in situ and its relationships to 8-Hydroxyguanine ( 8-OH-dG ) in lung cancer and normal tissues , respectively .

目的探讨血清谷胱甘肽硫转移酶（GST）和尿8羟基脱氧鸟苷（8OHdG）作为焦炉工人多环芳烃（PAHs）暴露生物监测标志的可行性。

Objective To investigate the application of serum glutathione S-transferase ( GST ) and urinary 8-hydroxy-2-deoxyguanosine ( 8-OHdG ) as the monitoring biomarkers for coke oven workers exposed to polycyclic aromatic hydrocarbons ( PAHs ) .

目的探讨尿中8-羟基脱氧鸟苷（8OHdG）作为肿瘤手术治疗和化疗效果监测与评价生物标记物的可行性。

Objective To investigate urinary 8-hydroxydeoxyguanosine ( 8OHdG ) as a biomarker of evaluating and monitoring the effect of surgical therapy and chemotherapy for tumor patients .

目的研究灌服中药扶正解毒汤（FJD）后兔血清对硫酸镍（NiSO4）暴露的人支气管上皮细胞（16HBE）自由基含量及8-羟基-2-脱氧鸟苷三磷酸酶（8-oxo-dGTPase）表达的影响。

Objective To study the effect of drug contained rabbit serum , prepared by gastric perfusion with fuzheng Jiedu Decoction ( FJD ), on the free radicals and expression of 8-oxo-dGTPase in cells exposed to nickel sulfate ( NiSO_4 ) .

血清8-羟基脱氧鸟苷水平升高与癌症相关性抑郁的临床意义

Increased Serum Levels of 8-Hydroxy-2 ' - Deoxyguanosine in Cancer-related Depression

8-羟基脱氧鸟苷在宣威地区女性肺癌中的表达研究

The Expression Study of 8-hydroxy-2-deoxyguanosine in the Xuanwei Female Lung Cancer

氧化应激对人淋巴细胞8-羟基-2'-脱氧鸟苷三磷酸酶表达的影响

The Expression of 8-oxo-dGTPase in Human Lymphocytes by Oxidative Stress

焦炉工人血清谷胱甘肽硫转移酶活力和尿8-羟基脱氧鸟苷水平

Analysis of serum glutathione S-transferase and urinary 8-hydroxy-2-deoxyguanosine in coke oven workers

8-羟基脱氧鸟苷检测方法的研究进展

The Progress of 8 - hydroxy - 2 ′ - deoxyguanosine Detecting Method

建立8-羟基脱氧鸟苷的检测新方法具有重要的生物医学意义。

To develop novel detection method for8-hydroxy-2 ' - deoxyguanosine has important medical significance .

鼻咽癌患者血清和鼻咽组织中8-羟基脱氧鸟苷含量的变化

Detection of 8-hydroxy-2 ' - deoxyguanosine in serum and tissue in patients with nasopharyngeal carcinoma

标准石英粉尘及青石棉直接诱导8-羟基脱氧鸟苷加合物形成的研究

Study on the formation of 8-hydroxy-2 ' - deoxyguanosine adduct directly induced by standard silicon dust and crocidolite

左归丸对老年大鼠大脑皮质8-羟基脱氧鸟苷酸的调节作用

Effect of Zuogui Wan on 8 - hydroxy - 2 ′ - deoxyguanosine of Neocortex of Aging Rats

8-羟基脱氧鸟苷与吡啰红Y作用的共振光散射光谱及分析应用

Resonance light scattering spectra of interaction of 8-hydroxy-2 ′ - deoxyguanosine with pyronine Y and its analytical application