肺间质纤维化

随着现代医学的深入研究，特发性肺间质纤维化在治疗上有了一定的进展，但目前尚没有理想的治疗药物。

Although the modern medicine research has reached certain progress on IPF therapy , there is no ideal therapy drug for IPF .

CT及高分辨率CT在判断肺气肿患者肺间质纤维化程度及预后中的价值

Value of CT and high-resolution CT in evaluating the degree of pulmonary interstitial fibrosises and prognosis of pulmonary emphysema

Fas信号转导与肺间质纤维化

Signal Transduction of Fas and Pulmonary Interstitial Fibrosis

目的探讨建立一种由免疫复合物（IC）介导模拟特发性肺间质纤维化病变动物模型。

Objective To study an idiopathic pulmonary fibrosis ( IPF ) model mediated by immuno - complex ( IC ) .

特发性肺间质纤维化与其它肺间质性病变的HRCT表现

The HRCT appearances of idiopathic pulmonary fibrosis and other interstitial lung disease

ICAM-1在实验性肺间质纤维化中的表达及盐酸氨溴索的影响

Expression of ICAM-1 on Pulmonary Interstitial Fibrosis in Rats and the Effect of Ambroxol

目的分析胸片DR后处理功能在特发性肺间质纤维化（IPF）诊断中的作用。

Objective To evaluate the value of DR post process in diagnosis of IPF .

方法：采用气管内注射博来霉素A5建立肺间质纤维化的大鼠模型。

Methods : Model rats were induced by injecting bleomycin A5 into trachea .

前言肺间质纤维化（PulmonaryInterstitialFibrosis，PF）是一种原因不明、发病机制不清、缺乏治疗手段的致命性弥漫性肺间质病。

Background : Pulmonary fibrosis is a fatal diffuse interstitial lung disease with unknown cause , pathogenesis is unclear and the lack of treatment .

余140只SD大鼠经气管内一次性灌注博莱霉素A5，按BLM5mg·kg-1体重诱导大鼠肺间质纤维化，随机取40只为模型组。

Pulmonary fibrosis model was induced by intratracheal instillation of bleomycin ( 5mg / kg body weight ) .

晚期（≥14d）则以肺间质纤维化和肺小囊性变多见。

Late findings (≥ 14d ) were pulmonary fibrosis and microcyst formation .

目的通过腺苷（ADO）受体拮抗剂茶碱（TH），探讨ADO、双哌达莫（DPM）对小鼠肺间质纤维化过程的干预作用。

Objective To evaluate the effect of dipyridamole ( DPM ) and adenosine ( ADO ) on interstitial pulmonary fibrosis in mice .

肺间质纤维化大鼠肺泡巨噬细胞STAT1的活化及其依赖性免疫应答基因ICAM-1的表达

STAT_1 activation and STAT_1 - dependent immune-response gene ICAM-1 expression in alveolar macrophages of rats suffered from interstitial pulmonary fibrosis

另外，在接受胸部CT检查的54例患者中，有17例（31.5%）出现不同程度的肺间质纤维化改变，6例（11.1%）出现胸膜增厚、粘连。

Of the 54 cases having received additional thoracic CT scanning , interstitial fibrosis of different degree was seen in 17 ( 31.5 % ) and pleural thickening with adhesion in 6 ( 11.1 % ) .

在诸多肺部慢性疾病如支气管哮喘、肺间质纤维化及慢性阻塞性肺疾病（COPD）等疾病的发生、发展中均存在呼吸道重塑。

Airway remodeling is present in the process of mang lung chronic diseases , such as asthma , idiopathic pulmonary fibrosis , and chronic obstructive pulmonary disease ( COPD ) .

其包括特发性肺间质纤维化（idiopathicpulmonaryfibrosisIPF）、尘肺、过敏性肺炎、结节病、放射和药物引起的肺纤维化以及胶原血管病导致的纤维化等多种类型。

It has many types including interstitial idiopathic pulmonary fibrosis ( IPF ), pneumoconiosis , hypersensitivity pneumonitis , sarcoidosis , radiation and drug-induced pulmonary fibrosis and fibrosis caused by collagenvascular disease .

结果12例患者肺部CT及HRCT均表现为不同程度的肺间质纤维化，并以两肺外周分布为主，磨玻璃样密度影以及小叶间隔增厚为其常见表现。

Results CT and HRCT scans showed pulmonary interstitial diseases in different degree mainly localized periphery of lung in all cases , the ground-glass opacity and interlobular septal thickening were preliminary features of pSS .

在肺间质纤维化形成中，I型和III型前胶原mRNA表达呈动态变化，早期肺泡炎以III型前胶原mRNA大量增生为主，晚期纤维化期以I型前胶原mRNA增生为主。

III procollagen mRNA expression was increased in the acute alveolitis phrase of pulmonary fibrosis induced by Bleomycin , the expression of type I procollagen mRNA was mainly increased in the chronic stage of pulmonary fibrosis .

润肺养血颗粒中养阴药对肺间质纤维化大鼠血浆TXB2、ET-1的影响

The Effect of the Drug of Nourishing-Yin among the Improving-Lung-and-Nourishing-Yin Particles on the Development of Pulmonary Fibrosis and the Change of Serum TXB_2 、 ET-1

特发性肺间质纤维化患者血清TGF-β1、IL-10、IL-13水平变化及临床意义探讨

Studies on the Clinical Significance of the Change of Serum Levels of TGF - β _1 、 IL-10 、 IL-13 in Patients with Idiopathic Pulmonary Fibrosis

结果COPD合并肺间质纤维化的临床表现介于两种疾病之间，肺功能检查为混合性通气功能障碍或先为阻塞性通气功能障碍，之后逐渐演变成混合性通气功能障碍。

Results Clinical characteristics of COPD with pulmonary fibrosis were between COPD and pulmonary fibrosis . Lung function test showed mixed ventilation disturbance s or mixed ventilation disturbance appeared behind obstruction ventilation disturbance .

特发性肺间质纤维化病人外周血单核细胞中DcR3基因表达的意义

Significance of over expression of DcR_3 gene in peripheral blood mononuclear cells of the patients with idiopathic pulmonary fibrosis

结论与国外资料提示pSS患者死亡主要与恶性淋巴瘤相关不同，我国pSS患者最常见的死亡原因为肺间质纤维化伴感染。

Conclusion In China , lung interstitial fibrosis complicated with infection is the most common cause of death with pSS , which is different from other countries ′ malignant lymphoma .

目的探讨气泵雾化吸入普米克令舒治疗特发性肺间质纤维化（IPF）的临床疗效。

Objective To investigate the clinical effect of air compressor pump atomizing inhalation with pulmicort respules on idiopathic pulmonary fibrosis ( IPF ) .

结果7例患者接受TBLB，6例病理诊断为肺间质纤维化。

Results TBLB was performed in 7 patients in which 6 cases were diagnosed as interstitial pulmonary fibrosis .

目的探讨类风湿关节炎（RA）并发肺间质纤维化的发生情况、临床特点、肺功能、影像学检查及相关因素，加深对RA肺间质病变的认识。

Objective To explore the occurrence , clinical characteristics , pulmonary function , radiographic find - ings and the associated factors of pulmonary interstitial fibrosis in rheumatoid arthritis ( RA ) to build up knowledge for early diagnosis .

结果PSS发生内脏损害中以肺间质纤维化占首位，然后依次为肝脏损害、肺动脉高压、肾小管损害、血液系统病变等；

Results Pulmonary interstitial fibrosis took the first place among the visceral lesion manifestations , and then came liver involvement ( cirrhosis with ascites ), pulmonary hypertension , renal tubular abnormalities , leucocytopenia or thrombocytopenia .

方法：回顾性分析18例特发性肺间质纤维化（IPF）及20例继发慢性肺间质性疾病的临床及高分辨率CT（HRCT）表现特点。

Methods : Eighteen cases of idiopathic pulmonary fibrosis ( IPF ) and twenty cases of interstitial lung disease with other causes were retrospectively analyzed by clinical feature and high resolution computed tomography ( HRCT ) characteristics .

方法：应用生化方法检测11例特发性肺间质纤维化（IdiopathicPulmonaryFibrosis，IPF）、18例结节病患者及7例健康非吸烟者血清及支气管肺泡灌洗液一氧化氮（NitricOXide，NO）浓度。

Methods : With biochemical method , nitric oxide ( NO ) levels in the serum and BALF from 11 patients with idiopathic pulmonary fibrosis ( IPF ), 18 with sarcoidosis , and 7 normal subjects ( non smokers ) were determined .

近年来的研究证实，Fas信号转导及调节机制在肺间质纤维化中也起关键作用，对这一机制的认识可能为肺间质纤维化的治疗开辟新的方向。

It has also been proved that Fas signaling plays a critical role in pulmonary interstitial fibrosis in recent years . The recognition of this mechanism may provide a new method in the therapy of current - pulmonary interstitial fibrosis .