细胞衰老

筛选机制与细胞衰老的DNA损伤假说

Selective Mechanisms and the DNA Injury Hypothesis of Cell Senescence

端粒酶的主要功能是复制端粒末端DNA，维持端粒长度。端粒酶活性调节与肿瘤发生和细胞衰老有着密切关系。

The main function of telomerase is for the replication of telomere DNA , which is closely related with tumor and cell senescence .

加拿大的遗传学家已经发现了解开细胞衰老、死亡之谜的线索。

Geneticists in Canada have discovered a clue to the puzzle of why our cells get old and die

DNA去甲基化对细胞衰老的影响

The Effect of Demethylation of Genomic DNA on Cell Aging Process

DNA损伤监测及修复相关酶与细胞衰老

Cell Senescence and the Enzyme System for Surveillance and Repair of DNA Damage

这说明DNA合成障碍是皮肤细胞衰老的根本原因。

This shows the basic reason for skin aging is DNA synthesis obstruction of cells .

目的：研究DNA甲基化水平变化对细胞衰老进程和端区长度的影响。

Objective : The effect of DNA demethylation on aging process and telomere length was studied .

H2O2诱发人成纤维细胞衰老样变化的基因表达谱

Profile Gene Expression of H_2O_2-induced Premature Senescence of Human Fibroblasts

细胞衰老过程中P53表观遗传学修饰

Epigenetic modifications of P53 during cellular senescence

~（137）Csγ射线照射建立成骨细胞衰老模型的研究

Establishing an ageing model of osteoblasts with ~ ( 137 ) Cs γ - ray irradiation

Rb基因与细胞衰老的研究进展

Advances in the Study of Rb Gene and Cell Senescence

外源性Rb基因对神经细胞衰老的影响

Effect of exogenous Rb gene on senescence of neurocytes

AngⅡ诱导血管内皮细胞衰老相关基因表达的研究

Study on gene expression associated with senescence of endothelial cell induced by angiotensin ⅱ

本研究旨在研究增龄或限制能量摄入（CR）对胰岛细胞衰老及胰岛素分泌的影响。

We observed the influence of aging or caloric restriction ( CR ) on pancreatic beta cell senescence and its insulin secretion .

细胞衰老过程是借助于信号传导途径实现的，其中Rb和p53控制的信号途径起重要作用。

Cell senescence is implemented by signal transduction pathways among which Rb and p53 are extremely important .

藻红蛋白诱导人乳腺癌MCF-7细胞衰老研究

Study on the senescence induced by phycoerythrin in human breast cancer MCF-7

端粒酶是一种特殊逆转录酶，能合成DNA添加到染色体末端，以保持染色体稳定性，阻止细胞衰老、死亡。

Telomerase is a special reverse transcriptase , which synthetises and addes DNA to the end of chromosome to maintain its stability and prevent senesence and death of cells .

3个上调表达，其中1个为推定的AP蛋白，和植物细胞衰老、凋亡相关；

Were found to be up-regulated . They are 1 Putative aspartic protease concerning to plant cell senescence and apoptosis .

结论：在HUVEC中，端粒与细胞衰老之间存在联系；

Conclusions : In HUVEC there is some relation between MTL and senescence .

提示ROS是引起血管细胞衰老的重要机制之一。

These results suggest ROS is an important mechanism for inducing ageing of blood vessel cells . 2 .

最近发现miRNA参与调控细胞衰老。

Recently , miRNA has been found involving in the regulation of cell senescence .

人参皂甙Rg1对抗三丁基过氧化氢诱导的细胞衰老作用及其可能机制

Anti-aging Effect of Ginsenoside Rg1 on t-BHP-induced Premature Senescence and Its Possible Mechanism

近年来，许多研究发现miRNA参与调控细胞衰老。

Recently , it has been found that miRNA involves in the regulation of cell senescence .

红细胞衰老时P（50）改变、Hb和K~＋的外漏及麦芽醇的保护作用

The change in the level of P_ ( 50 ), Hb , K ~ + leaking out from human red cells during aging and the antioxidant action of maltol on erythrocyte aging

消减杂交筛选2BS细胞衰老过程中差异表达基因

Screening for Differentially Expressed Genes upon 2BS Fibroblasts Senescence by Subtractive Hybridization

说明天麻多糖具有较好的清除自由基，降低MDA的含量，延缓细胞衰老的作用。

These results demonstrate that the polysaccharide from the Gastrodia elata Blume possess the reliable function of eliminating free radicals and inhibiting the formation of MDA and delaying cell aging .

目的观察外源性Rb基因对神经细胞衰老的影响，并探讨Rb基因对神经细胞P21基因表达的调控。

Objective To investigate the effect of exogenous Rb gene on senescence of neurocytes and explore regulation of p21 gene expression by Rb gene .

t一BHP可诱导Wl一38细胞衰老，可用于建立体外细胞衰老模型。

Conclusion : t-BHP can be used to induce WI-38 cells senescence and to establish a model of premature senescence .

不同剂量睾酮干预心肌细胞衰老中p16~（INK4a）的表达

The role of p16 ~ ( INK4a ) in the intervention of testosterone on senescence of murine cardiac myocytes

为了探讨三七皂甙Rg1对D-半乳糖所致衰老模型鼠氧化损伤及星型胶质细胞衰老的保护作用。

In order to explore the protective effect of sanchi saponin Rg1 on oxidative injury and aging of astrocyte in D-galactose induced aging mice model .