组蛋白去乙酰化酶

这些结果显示，即使组蛋白去乙酰化酶可以作为治疗AD的潜在靶点，但是持续的用药还是必需的。

These results indicate that although histone deacetylase can be served as a potential target for treating AD , continuous drug administration may be required .

研究背景：组蛋白去乙酰化酶抑制剂（HDACi）是一类能够有效抑制抑制肿瘤细胞增殖、诱导细胞分化、促进细胞凋亡的抗肿瘤新药。

Background : Histone deacetylase inhibitor ( HDACi ) is a promising class of anticancer agents with high efficiency on inhibiting tumor growth , inducing cell differentiation and / or apoptosis .

靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。

Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials .

组蛋白去乙酰化酶抑制剂诱导HeLa细胞p21~（WAF1/CIP1）表达的分子机制研究

Molecular mechanism of p21 ~ ( WAF1 / CIP1 ) expression induced by histone deacetylase inhibitors in HeLa cell line

结果表明：组蛋白去乙酰化酶抑制剂TSA可有效的诱导MOLT-4细胞发生G2／M阻滞和凋亡，并且呈现明显的剂量效应关系和时间效应关系；

The results showed that TSA could effectively induce G2 / M arrest and apoptosis of MOLT-4 cells .

Raf激酶抑制蛋白介导的信号通路对肝癌侵袭转移的抑制作用组蛋白去乙酰化酶抑制剂及甲基转移酶抑制剂协同抑制造血干细胞分化

Inhibition Effects of Signal Transduction Mediated by Raf Kinase Inhibitor Protein on Invasion and Metastasis of Hepatocellular Carcinoma

目的：探讨组蛋白去乙酰化酶（HDAC）抑制剂对系统性红斑狼疮（SLE）患者外周血全血培养细胞中IL-10和IL-12分泌水平的影响。

Objective : To explore the effect of histone deacetylase inhibitors on the excretion levels of IL-10 and IL-12 in patients with SLE .

目的：改进组蛋白去乙酰化酶抑制剂SAHA的合成工艺。

Objective : To improve the synthetic procedure of the histone deacetylase ( HDAC ) inhibitor SAHA .

目的：研究组蛋白去乙酰化酶抑制剂曲古抑菌素A（TSA）对前列腺癌LNCaP细胞抑制作用的细胞信号机制。

AIM : To investigate the molecular mechanisms underlying the antitumor effect of trichostatin A ( TSA ) on LNCaP prostate cancer cells .

结论组蛋白去乙酰化酶引起的组蛋白H4去乙酰化与干扰素γ激活IP-10基因有关。

Conclusion The histone H4 deacetylation at the ISRE site is related with the activation of IP-10 by IFN-gamma .

丙戊酸（valproicacid，VPA）作为一种组蛋白去乙酰化酶抑制剂，能特异性抑制组蛋白去乙酰化酶的活性，提高细胞内组蛋白乙酰化水平，激活基因的表达。

Valproic Acid ( VPA ), a histone deacetylase inhibitor , could specifically inhibit the histone deacetylase activity , increase histone acetylation , and active gene expression in somatic cells .

本实验通过一种组蛋白去乙酰化酶抑制剂TSA来诱导不同时期胚胎核心组蛋白高乙酰化，观察其对早期胚胎发育能力及相关基因mRNA表达水平变化的影响。

Trichostatin A ( TSA ), one of the inhibitors of HDACs , was used to determine the effects of core histone hyperacetylation on development ability and expression level of relational gene mRNA in different developmental embryos .

另外，组蛋白去乙酰化酶抑制剂TSA诱导组蛋白超乙酰化，促进Sp1与mda-7启动子结合，进而激活mda-7的表达。

Moreover , HDAC inhibitor TSA induced histone hyperacetylation and stimulated Sp1 binding to mda-7 promoter , which in turn enhanced the expression of mda-7 .

已有报道证实组蛋白去乙酰化酶抑制剂（HDACi）可以引起哺乳动物基因组的去甲基化，这支持了DNA甲基化和组蛋白修饰可以相互作用调节基因的表达的观点。

Histone deacetylase inhibitor ( HDACi ) has been shown to demethylate mammalian genome , which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression .

组蛋白去乙酰化酶（HDACs）通过调节转录因子的活性等影响成骨发育。

Histone deacetylases are enzymes ( HDACs ) that can regulate the activity of transcription factors and affect bone development .

本研究运用RNA干扰技术对小鼠HDAC2进行了干扰，通过抑制组蛋白去乙酰化酶的表达提高乙酰化修饰水平，以探索表观遗传修饰影响哺乳动物胚胎早期发育的可能机制。

This study was designed to improve the level of acetylation by knock down the expression of histone deacetylase expression with RNA interference technology . A possible mechanism was provided for improving epigenetic modifications and exploring the early development of mammalian embryos . 1 .

因此，本试验以TSA为代表药物，研究组蛋白去乙酰化酶抑制剂对猪卵巢颗粒细胞的作用，并就其机理作初步探讨，以为临床用药提供一定的参考。

Therefore , this study aims to investigate the effect of histone deacetylase inhibitors on porcine granulosa cells and its preliminary mechanism . All the results can provide a reference for clinical use .

组蛋白去乙酰化酶（HDAC）对染色质分布和基因调节起着重要的作用，也是治疗癌症和其它疾病的新靶点。

Histone deacetylase ( HDAC ) greatly affects the chromatin topology and gene expression , and HDAC can be a new strategy in human cancer or tumour therapy .

目的：本研究探讨组蛋白去乙酰化酶抑制剂TrichostatinA（TSA）联合化疗药物顺铂（DDP）处理人卵巢癌顺铂耐药株C13的协同效应。

Objective : To investigate the synergistic effects of a histone deacetylase inhibitor , trichostatin A ( TSA ), combined with cisplatin ( DDP ) on cisplatin-resistant ovarian epithelial cancer cell line C13 .

目的：观察组蛋白去乙酰化酶（HDAC）抑制剂曲古霉素A（TSA）对体外培养膀胱癌细胞生长情况及相关基因表达的影响，并探讨其可能的作用机制。

Objective : To investigate the influence of trichostatin A ( TSA ), a histone deacetylase ( HDAC ) inhibitor , on the growth of human bladder cancer cells and on the expression of related genes , and to explore the mechanism involved .

相对于其它种类的组蛋白去乙酰化酶抑制剂，环肽类组蛋白去乙酰化酶抑制剂对组蛋白去乙酰化酶表现出了高效的抑制作用。

Cyclic tetrapeptide histone deacetylases inhibitor is one of effective types .

羟肟酸类抑制剂是目前研究最多的组蛋白去乙酰化酶抑制剂。

Hydroxamic acid compounds are component of most of the HDAC inhibitors .

组蛋白去乙酰化酶1在肺腺癌发生发展中的作用

Role of Histone Deacetylase 1 in Human Lung Adenocarcinoma Carcinogenesis

靶向组蛋白去乙酰化酶新型化合物的体外抗肿瘤活性筛选

Screening the in Vitro Anti-tumor Activities of Novel Synthetics Targeting to Histone Deacetylases

组蛋白去乙酰化酶1在人肺癌组织中的表达

Expression of Histone Deacetylase 1 in Human Lung Cancer

以组蛋白去乙酰化酶为靶点的异羟肟酸类小分子抑制剂的设计、合成及生物活性研究

Design , Synthesis and Bioactivity Study of Novel Small-molecule Hydroxamates as Histone Deacetylases Inhibitors

基于结构的组蛋白去乙酰化酶抑制剂虚拟筛选

Structure based virtual screening of HDAC inhibitors

组蛋白去乙酰化酶1在气管干细胞增殖分化过程中的时空表达

Dynamic Changes of Histone Deacetylase 1 during Regulated Growth of Bronchial Stem Cells in Human Bronchial Regeneration

慢性阻塞性肺病外周血单个核细胞中的组蛋白去乙酰化酶活性与全身炎症的关系

Relationship Between Systemic Inflammation and Activity of Histone Deacetylase in Peripheral Blood Mononuclear Cells from COPD Patients

组蛋白去乙酰化酶是一类通过调节组蛋白乙酰化的程度来影响细胞周期、分化和凋亡的蛋白。

Histone deacetylase is protein that can influence the cell cycle , differentiation and apoptosis through the modification of acetyl level of histones .