碱基堆积

详细的能量分析发现：在配合物插入碱基堆积过程中的空间位阻状况决定了识别作用的结果，静电相互作用也在一定程度上产生了影响。

Detailed energy analysis indicated that the steric interaction in the process of the complex inserting to base stacking determined the recognition results and the electrostatic interaction made an effect in some extent .

经H2O2处理后，DNA水溶液的A型构象有所增强，碱基堆积程度下降。

A-type conformation of DNA in aqueous solution is dominated after treatment of H_2O_2 for 48h .

双链DNA分子中碱基对的紧密堆积为电子传递提供了有利条件，DNA内的电子转移与许多生物学功能密切相关，可能诱发遗传信息的错读和引起DNA损伤，导致细胞的突变和癌变。

The closely-stacking base pairs in double helical DNA provide a favorable medium to facilitate electron transfer . The electron transfer in DNA relates to many biological functions , which may lead to genetic information misinterpretation and DNA damage resulting in cell mutation and cancerization .