硒蛋白

利用组织芯片技术检测硒蛋白P在胃癌组织中的表达

Expression of selenoprotein P in multiple carcinoma tissues with tissue microarray

小同功型人硒蛋白P的诱导凋亡活性

The apoptosis - inducing activity of human selenoprotein P shorter isoform

硒蛋白P凋亡功能结构域的确定及其突变体诱导人肝癌细胞BEL-7204凋亡的初步研究

Domain of Selenoprotein P Identification and Its Mutant Function Study

其它含硒蛋白（如硒蛋白P和硫氧还蛋白还原酶）也具有抗氧化特性。

Moreover , other selenoproteins ( e.g. selenoprotein P and thioredoxin reductase ) also have been shown to possess antioxidant properties .

大鼠脱碘酶、硒蛋白P和硒蛋白W正常表达所需的最低饲料硒水平

The least dietary selenium requirements for normal expression of deiodinase and selenoprotein P and W in rats

Se是含硒蛋白的一个组分，有维持酶蛋白催化功能的作用。

As a constituent of selenoproteins , selenium has effect in maintaining catalytic function of zymoprotein .

SDS－PAGE和HPLC－荧光检测分离鉴定恩施高硒区大豆中含硒蛋白

SDS-PAGE Seperation and HPLC - FID Identification of Selenoproteins in Soybean from Enshi Area Having a Higher Level of Selenium in Soil

结果：硒蛋白P在结肠癌组织中的阳性表达率（60.0%）低于其在正常结肠组织中的表达率（80.0%），二者相差有统计学意义（P<0.05）；

RESULTS : The expression rate of selenoprotein P in colon carcinoma ( 60.0 % ) was significantly lower than that of their control normal tissues ( 80.0 % , P < 0.05 ) .

介绍了硒的生理生化特性，重点阐述了硒与谷胱甘肽系统在抗氧化防御体系中的作用以及硒蛋白的研究进展。硒和谷胱甘肽（GSH）系统在氧化防御反应中起着关键性作用。

In the context of dense against pro-oxidants , selenium and the glutathione ( GSH ) system play key functions .

硒是哺乳动物最重要的必需微量营养元素之一，它主要以硒代半胱氨酸（Sec）的形式存在于硒蛋白中。

Selenium is one of the most important essential micronutrient elements in mammal , which mainly was shown to be incorporated as selenocysteine ( Sec ) in selenoprotein .

一种独特的tRNA、某些特殊蛋白质因子以及硒蛋白mRNA的特殊二级结构是UGA解读为硒代半胱氨酸所必需的。

The decoding of UGA as selenocysteine requires a unique tRNA , some proteins , and special secondary structure in the mRNA .

分别采用ICP-MS法和苯酚硫酸法及考马斯亮蓝法对硒多糖和硒蛋白中硒、多糖及蛋白含量进行测定；

The contents of selenium , polysaccharide and protein in Se-polysaccharide and Se-protein were determined by ICP-MS , phenol-sulfuric acid method and Coomassie brilliant blue method .

实验得到结论：Se-GL-P是一种新的硒蛋白，并属于功能性DING蛋白家族的一员。

A conclusion was drawn that Se-GL-P was a kind of new selenium-containing protein , and it was one member of DING protein family .

硒蛋白W（SelW）是硒蛋白家族的一员，在多种动物的不同组织中均可表达，并且哺乳动物SelW可以作为一种氧化还原酶。

Selenoprotein W ( SelW ) is a member of the selenoprotein families , expressed in various tissues of many animals and acted as an oxidoreductase in mammals .

利用生物软件在基因组数据库中通过识别SECIS元件检索硒蛋白基因是一种重要的方法。

It is an important method for searching the selenoprotein in genome databases by identifying the SECIS element with the bio-softwares .

针对上述表达区段没有发现TGA碱基区的问题，再次对目标序列进行了更为全面的搜索和分析研究，又发现另一段同时具有与衣藻硒蛋白相似结构特征和TGA碱基区的序列段。

Aiming at the query that there was no TGA in the above-mentioned sequence , more full-scale searching work was made and another expressed sequence which has TGA and the similar structural character with the selenoproteins of Chlamydomonas was found .

方法采用75Se活体标记、SDS-PAGE和γ射线探测等技术研究睾丸组织中含硒蛋白的分布。

Methods The Se containing proteins in testis of the rat were investigated by in vivo labeling with 75 Se selenite , separation of the tissue homogenate proteins by SDS PAGE , and determination of the labeled proteins by γ detector and γ counter .

本文就硒代半胱氨酸插入元件（SECIS）结构特征、从基因组中寻找硒蛋白的生物信息学方法及其研究进展作了简要介绍，并对未来的发展趋势进行了展望。

The structural character of the selenocysteine insertion sequences ( SECIS ), the bioinformatics methods of searching selenoprotein from genome and their research progress are introduced .

研究结果显示：1.硒蛋白多糖中，蛋白质、多糖及硒含量分别为16.32%、81.20%、7.01mg/g。

The content of protein , selenium and polysaccharide , which are active ingredient of rich A blazei , were 16.32 % , 81.20 % and 7.01mg/g respectively .

动物硒蛋白种类及其生化功能的研究进展

Progress of Study on Animal Selenium Proteins and Their Biochemical Functions

硒的主要生物功能是通过硒蛋白实现的。

The biological function of selenium is mainly exerted through selenoproteins .

硒蛋白对小鼠抗辐射损伤作用的研究

Resistance of selenium protein to the radiation harm in rats

硒蛋白对心血管疾病辅助治疗的临床评价

Clinical evaluation of the supplementary treatment of selenium protein for cardiovascular disease

微量元素硒代谢及硒蛋白基因表达调控最新研究进展

Recent Advances of Se Metabolism and Gene Expression of Selenoprotein

人肝脏组织亚细胞组分中含硒蛋白的分离与测定

Isolation and Determination of Selenium-containing Proteins in Subcellular Fractions of Human Liver

硒蛋白的分子生物学及与疾病的关系

The Molecular Biology of Selenoproteins and Their Effects on Diseases

大豆硒蛋白的生物学功能初探

A preliminary approach to biological function of soybean Selenoprotein

低硒大鼠不同组织硒蛋白利用硒的优先性

Preference of selenium incorporating into selenoproteins in different tissues in selenium depleted rats

一种新的人血浆中含硒蛋白测定方法

A New Method for Separation and Identification of Selenium-containing Proteins in Human Plasma

大鼠睾丸组织中的含硒蛋白

A study on testis selenium-containing proteins of male rats