在真核细胞中，核小体的核心结构组蛋白被DNA紧密缠绕，但是这种紧密的结合有时也可能变得松散，以利于其他蛋白与DNA的结合。
Histone and DNA bind together to form the nucleosome , but this tight binding can loose at some times to facilitate other proteins to interact with DNA .
核小体核心