齐多夫定

金属离子对齐多夫定与牛血清白蛋白结合作用的影响

Effecting of Metal Ions on the Interaction between Zidovudine and Bovine Serum Albumin

世界卫生组织说应该用副作用较低的其他药物替代这种药物，例如泰诺福韦或齐多夫定。

The WHO says the drug should be replaced with less harmful alternatives such as tenofovir or zidovudine .

医生在用齐多夫定药物对他进行治疗。

Doctors are treating him with the drug AZT .

目的建立齐多夫定胶囊中AZT的含量测定方法。

OBJECTIVE To establish a method for determination AZT in AZT Capsule .

目的了解确山县抗艾滋病病毒（HIV）治疗过程中，接受治疗（治疗方案为齐多夫定胶囊、去羟基甘散和奈韦拉平片）的患者的免疫学和病毒学指标的变化和耐药毒株的出现情况。

Objective To find out the alterations of the immunological and virological indexes and the emergence of resistant strains in the patients undergoing anti-HIV therapy ( receiving Zidovudine , Didanosine and Nevirapine ) .

30min内脂质体组肝、脾、肾和脑（15min内）中齐多夫定的AUC值分别为溶液组的1.6倍、1.19倍、80%、1.8倍。

Compared to azidothymidine solution , the AUC ( 0-30 min ) in liver , spleen , kidney and brain ( 15 min ) were 1.6,1.19,0.8 and 1.8 times , respectively .

方法采用乙醇注入法制备齐多夫定棕榈酸酯脂质体；

Methods The azidothymidine palmitate was incorporated into liposomes by ethanol injection method .

齐多夫定的合成工艺改进

An Improved Synthetic Process of Zidovudine

国产齐多夫定胶囊的相对生物利用度为（102±11）%。

The relative bioavailability of domestic to imported capsule was ( 102 ± 11 ) % .

结论经统计学分析，国产齐多夫定胶囊与进口胶囊具有生物等效性。

CONCLUSION Statistic analysis showed that the domestic zidovudine capsule and imported zidovudine capsule were bioequivalent .

测定人血浆中齐多夫定的液相色谱-串联质谱法及生物等效性的应用

Determination of zidovudine in human plasma with LC / MS / MS method and application to a bioequivalence study