非诺贝特

非诺贝特对自发性高血压大鼠心肌重构及NF-κB表达的影响

Effect of fenofibrate on myocardial remodeling and NF - κ B expression in spontaneous hypertensive rats

HPLC法测定非诺贝特软胶囊的有关物质及含量

Determination of Fenofibrate Soft Capsules by HPLC Method

非诺贝特长期治疗对9795例2型糖尿病患者心血管事件的影响（FIELD研究）：一项随机对照试验

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus ( the FIELD study ): Randomised controlled trial

非诺贝特及罗格列酮对高糖培养肾小球系膜细胞核因子κB信号通路调控的影响

Effects of fenofibrate and rosiglitazone on signal passway of nuclear factor - κ B in glomerular mesangial cells incubated with high concentration of glucose

吡格列酮和非诺贝特对SD大鼠体脂分布及能量代谢的调节作用

Regulatory effects of pioglitazone and fenofibrate on body fat distribution and energy homeostasis in SD rats

目的评定单用金刚烷胺、金刚烷胺与复方丹参或丙炔苯丙胺合用对早期帕金森病（PD）患者治疗的效果和安全性。非诺贝特单独治疗引起横纹肌溶解症临床分析（附3例报告）

Objective To assess the clinical efficacy and safety of amantadine monotherapy and concomitant amantadine with salvia miltiorrhiza compound or selegiline of the treatment of Parkinson 's disease .

而非诺贝特和AngⅡ几乎同时处理细胞时，则无明显效应。

In contrast , Fenofibrate had no significant effect on Ang ⅱ treated cardiac myocytes when Fenofibrate treatment was concomitant with Ang ⅱ .

HTG组非诺贝特治疗后，ISI较治疗前显著升高（18.35±1.76vs9.40±1.76，P＜0.01）；

As compared with pre-therapy in HTG group , ISI was significantly increased after fenofibrate treatment ( 18.35 ± 1.76 vs 9.40 ± 1.76 , P < 0.01 );

方法56例高脂血症的肾移植患者服用微粒化的非诺贝特200mg/d，一个月后观察其血脂、尿酸水平和CsA浓度的变化。

Methods : 56 hyperlipidemic cases were treated with fenofibrate ( 200mg / d ) for one month , the serum concentration of lipids and CsA were analyzed .

末次灌胃后1h异丙肾上腺素组和非诺贝特组给予异丙肾上腺素5mg/kg腹腔注射复制急性心肌缺血损伤模型；

After the last gastric perfusion for 1 hour the rats in the isoproterenol group and fenofibrate group were given 5 mg / kg isoproterenol with intraperitoneal injection to replicate acute myocardial ischemic damage models .

PEG4000十烷硫酸钠体，溶剂-熔融制备非诺贝特固体散体，再适辅混合压片制非诺贝特固体散片。

Fenofibrate solid dispersion tablets were prepared by solvent melting method using PEG4000 and sodium lauryl sulfate .

非诺贝特对高脂喂养的糖尿病大鼠骨骼肌UCP3基因表达的影响

Effect of fenofibrate on the expression of uncoupling protein 3 gene in skeletal muscle of diabetic rats fed with high fat diet

不同浓度的非诺贝特呈剂量依赖性降低OxLDL诱导的脂肪细胞TNF-α分泌及mRNA表达，而相应的PPARαmRNA的表达则无显著变化。

The pretreatment of adipocytes with fenofibrate inhibited TNF - α mRNA expression induced by OxLDL and reduced release of TNF - α in adipocytes with a dose-dependent manner . However , no significant changes were observed on PPAR α mRNA expression .

非诺贝特治疗后脂肪组织PAI-1mRNA表达明显低于高胆固醇组（P<0.01）。

Fenofibrate obviously inhibited PAI-1 mRNA expression in adipose tissue ( P < 0.01 ) .

结果①相同实验条件下，微粉化非诺贝特胶囊降低高血脂大鼠血清TC和TG的最低有效剂量为每天30mg·kg-1，而标准化非诺贝特胶囊为每天80mg·kg-1；

RESULTS 1 In the same experimental conditions , the minimal efficacious dose of the micronised fenofibrate is 30 mg · kg - 1 , but that of the standard fenofibrate is 80 mg · kg - 1 ;

三七总皂苷对大鼠肾小球系膜细胞CTGF表达及细胞外基质产生的影响非诺贝特和罗格列酮对高糖培养肾小球系膜细胞胞外基质产生和氧化应激的抑制作用

The Effects of PNS on Expressions of CTGF and Secretion Of ECM Of Cultured Rat Mesangial Cdis Inhibition of fenofibrate or rosiglitazone on production of extracellular matrix and oxidative stress of glomerular mesangial cells incubated with high concentration of glucose

目的观察长期高脂喂养对糖尿病（DM）大鼠骨骼肌解偶联蛋白3（UCP3）基因表达的影响以及非诺贝特治疗后其表达的变化。

Aim To explore the effect of long-term high fat diet on the expression of uncoupling ( UCP3 ) gene in skeletal muscle of diabetic mellitus ( DM ) rats , and the effect of the fenofibrate therapy .

方法：67例原发性高脂血症病人（男性51例，女性16例；年龄54a±s11a）给微粒化非诺贝特200mg，po，qn，疗程8wk。

METHODS : Sixty_seven patients ( M 51 , F 16 ; age 54 a ± s 11 a ) with hyperlipidemia received micronised fenofibrate 200 mg ( 200 mg / cap ), po , qn × 8 wk .

治疗组口服洛伐他汀胶囊，每日1粒，晚餐时一次顿服，对照组口服非诺贝特，每次1片（0.1g），每日3次；

In treating group , patients were given Lovastatin orally 1 tablet a time , once a day and taken after supper . In control group , patients were given Fenofibrate orally 1 tablet a time and 3 times a day .

非诺贝特减轻棕榈酸诱导的胰岛素分泌功能损害

Fenofibrate improves the impairment of insulin secretion caused by palmitic acid

替米沙坦与非诺贝特对高脂饮食大鼠血清脂联素水平的影响

Influence of Telmisartan and Fenofibrate on Adiponectin Level in High-fat-fed Rats

棕榈酸对胰岛的脂毒性及非诺贝特的保护作用

Lipotoxicity of palmitic acid on islets and protecting effect of fenofibrate

阿托伐他汀、非诺贝特、降脂通络软胶囊对混合型高脂血症患者血脂水平及肝功能的影响

The Influence of Statins Capsule for the Treatment of Combined Hyperlipidemia

非诺贝特对内皮细胞分泌E-选择素和细胞间黏附分子1的影响

The effects of fenofibrate on endothelial cell secretion of E-selectin and ICAM-1

降脂药非诺贝特的临床研究

A clinical investigation on a hyperlipemia remission drug & fenofibrate

微粒化非诺贝特对高三酰甘油血症患者血管内皮功能的作用

Effect of micronised fenofibrate on the endothelial function in patients with hypertriglyceridemia

中心复合设计法制备盐酸奈福泮微孔渗透泵控释片非诺贝特双层渗透泵制剂的处方优化

Preparation of nefopam hydrochloride controlled porosity osmotic pump by central composite design

微粒化非诺贝特治疗老年人高脂血症疗效观察

Treatment Efficacy of Micronized Fenofibrate in Elderly Patients with Hyperlipidemia

非诺贝特胶囊（微粒化）人体生物利用度研究

Bioavailability of Lipantil Capsule ( Micronized ) in Human Body

非诺贝特对脂肪组织凝血和纤溶因子表达的影响

Fenofibrate inhibits thrombogenic and fibrinolytic factors expression in adipose tissues