非受体酪氨酸激酶

非受体酪氨酸激酶ARG与过氧化氢酶相互作用机制的初步研究

Interaction of non-receptor tyrosine kinase Arg and catalase

凋亡诱导因子与非受体酪氨酸激酶c-Abl的相互作用

Study on Interaction Between Apoptosis-Inducing Factor and Non-Receptor Tyrosine Kinase C-Abl

非受体酪氨酸激酶c-Abl与Siva-1相互作用及在细胞凋亡中的功能研究

Interaction between non-receptor tyrosine kinase c-Abl and Siva-1 in cell apoptosis

c-Abl激酶是一种非受体酪氨酸激酶，它参与多种受体引起的信号转导，并且参与了F-肌动蛋白依赖的细胞骨架变化。

C-Abl kinase as a non-receptor protein tyrosine kinase plays an essential role in signaling transduction from various receptors and in F-actin reassembly .

非受体酪氨酸激酶c-Abl广泛表达于人和哺乳动物等的细胞中并受到严格调控，通过蛋白之间相互作用、与DNA相互作用及其酪氨酸激酶活性在一系列的重要生命活动中发挥调节作用。

The c-abl gene is expressed ubiquitously as a non-receptor tyrosine kinase in mammalian and human cells . c-Abl is implicated in many important cellular process by multiple protein-protein , protein-DNA interaction and its tyrosine kinase activity .

非受体酪氨酸激酶c-Ab1的在哺乳动物细胞内的编码基因c-abl是v-abl的同源基因，v-ab1是Abelson鼠白血病病毒原癌基因。c-Ab1蛋白属于非受体酪氨酸激酶Abl家族的成员，在哺乳动物细胞中能够广泛表达。

The non-receptor tyrosine kinase c-Abl in mammalian is the homeotic gene of v-abl which is proto-oncogene of Abelson in murine leukemia virus ; it belongs to the family members of the Abl , and can be widely expressed in mammalian cells .

其受体和非受体酪氨酸激酶途径受金属离子、细胞因子、氧化应激、原癌基因等的调节。

These pathways including receptor and non-receptor tyrosine kinase pathways are mediated by metallic cations , cytokines , oxidative stress , oncogene / pro-oncogene etc.

在中性粒细胞中，粘附引起的β2整合素的交联能够活化多种非受体酪氨酸激酶，这些激酶与细胞的骨架重排、生长、存活、运动密切相关。

In neutrophils , adhesion-induced ligation of β 2 integrin activates various non-receptor tyrosine kinases , which have been demonstrated critical in integrin signaling and leads to cytoskeleton rearrangements , cell growth , survival , and motility .

cCbl可以介导受体酪氨酸激酶和非受体酪氨酸受体激酶的降解。

Some studies reported that c Cbl exerted the negative regulation to receptor tyrosine kinases and non receptor tyrosine kinases by promoting their degradation .

脾酪氨酸蛋白激酶（Spleentyrosinekinase，Syk）是一种广泛表达在造血细胞、淋巴细胞、成纤维细胞、血管内皮细胞上的非受体蛋白质酪氨酸激酶，在细胞信号传导中起着重要的作用。

Spleen Tyrosine Kinase ( Syk ) is a non-receptor protein-tyrosine kinase . Its expression has been found in various cells such as the hematopoietic , lymphocyte , fibroblast and vascular endothelial cells .

SHP-1主要通过对生长因子受体或非受体蛋白酪氨酸激酶的脱磷酸作用起着重要的负性调节作用。

The important negative regulatory role of SHP-1 mainly affected the dephosphorylation of growth factor receptors or non-receptors protein tyrosine kinase .

Src蛋白是一种分子量约60KDa的非受体酪氨酸蛋白激酶。

Src is a kind of non-receptor protein tyrosine kinase of molecular weight ( Mr ) 60,000 that has two categories .

Lck激酶是非受体蛋白酪氨酸激酶Src家族的成员之一，特异性地在T淋巴细胞中表达，并且在T淋巴细胞的活化及发育过程中发挥着重要作用。

Lck kinase is a member of the Src family of non-receptor protein tyrosine kinases , which is expressed primarily in T lymphocytes and plays an important role in T cell activation and development .

非受体酪氨酸蛋白激酶Src是最早发现的原癌基因表达蛋白之一。其以两种形式存在：病毒原癌基因表达蛋白v-Src和细胞原癌基因表达蛋白c-Src，两者在进化上具有高度同源性。

The nonreceptor tyrosine kinase c-Src , first identified as an oncogenic protein , has two categories , including virus-Src ( v-Src ) and cell-Src ( c-Src ), Both of which are highly homologous with similar structures and protein tyrosine kinase ( PTK ) activity .

精了获能期蛋白酪氨酸磷酸化程度增高与sAC/cAMP/PKA途径、受体酪氨酸激酶途径和非受体蛋白酪氨酸激酶途径调节有关。

The increase in protein tyrosine phosphorylation during capacitation has been shown to be regulated by cAMP / PKA-dependent pathway , receptor tyrosine kinase pathway , and non-receptor protein tyrosine kinase pathway .