酪氨酸蛋白激酶

表皮生长因子受体酪氨酸蛋白激酶抑制剂筛选模型建立

Project Epidermal Growth Factor Receptor Tyrosine Protein Kinase Inhibitor Screen Model

黄芩素对人乳腺癌MCF-7细胞内酪氨酸蛋白激酶的抑制作用

Inhibitory Effect of Baicalein on Tyrosine Protein Kinase in Human Breast Cancer MCF-7 Cells

酪氨酸蛋白激酶受体B在人卵泡中的表达及意义

Expression of tyrosine kinase receptor B in human follicle

应用酪氨酸蛋白激酶（CKIT）免疫化学鉴定精原细胞。

Spermatogonium was identified by c-kit ( tyrosine protein kinase ) immunochemistry .

缺氧PC（12）细胞中细胞因子和酪氨酸蛋白激酶活性的变化

Changes of the cytokine and TPK activity in PC_ ( 12 ) cells after hypoxia injury

表皮生长因子受体（epidermalgrowthfactorreceptor，EGFR）家族是一类研究较多的酪氨酸蛋白激酶。

Epidermal growth factor receptor ( EGFR ) belongs to the family of trans-membrane growth factor receptor PTKs .

RNA干扰靶向抑制酪氨酸蛋白激酶对哮喘小鼠树突状细胞功能的影响

Small Interfering RNAs Specific for Spleen Tyrosine Kinase Inhibit Maturation of Dendritic Cells of Asthmatic Mice in Vitro

TNFα对小鼠骨骼肌和肝细胞膜胰岛素受体酪氨酸蛋白激酶活力影响

Effects of TNF α on Activity of Tyrosine Protein Kinase of Membrane Insulin Receptor of Muscle and Liver in Mouse

酪氨酸蛋白激酶抑制剂Genistein可以反转这种抑制效应。

Protein kinase inhibitor genistein could reverse the inhibitory effect .

Tec酪氨酸蛋白激酶的大鼠组织分布及参与的信号途径

Tissue distribution and signal transduction of Tec tyrosine kinase in rats

EGFR为受体型酪氨酸蛋白激酶，EGFR激活的关键步骤为二聚体形成及酪氨酸自身磷酸化。

EGFR is a tyrosine-protein kinase receptor ; the key steps of EGFR activation are the formation of dimers and their tyrosine phosphorylation .

Kit是位于细胞膜上的受体酪氨酸蛋白激酶，Myc是位于细胞核内的转录调节因子。

C-Kit is a receptor tyrosine protein kinase on the cellular membrane , while c-Myc is a transcription regulatory factor in the nucleus .

Bcr-Abl酪氨酸蛋白激酶域及其突变体的构建和表达

Production , expression and purification of Bcr - Abl tyrosine kinase domain and its mutants

survivin序列包含三个PKC活性位点、两个酪氨酸蛋白激酶位点和一个PKA位点。

The sequence of survivin include three phosphoric sites of PKC , two phosphoric sites of Tyr kinase and one phosphoric site of PKA .

原癌基因KIT，一种能被Gleevec抑制的酪氨酸蛋白激酶，在多数胃肠间质瘤中过度表达。

The proto-oncogene KIT , a tyrosine kinase that is inhibited by Gleevec , is overexpressed in a majority of GISTs .

设计并合成了四类共25个酪氨酸蛋白激酶（TPK）抑制剂。

Four classes of 25 tyrosine protein kinase ( TPK ) inhibitors were designed and synthesized .

胰岛素样生长因子I受体（insulin-likegrowthfactorIreceptor，IGF-IR）为跨膜蛋白，是酪氨酸蛋白激酶类受体家族的主要成员之一。

Type I insulin-like growth factor receptor ( IGF-IR ) is a transmembrane protein . And it is also one of the main members of the family of receptor protein tyrosine kinases ( PTKs ) .

目前研究认为IGF-I是神经干细胞增殖所必需，IGF-1可依循受体酪氨酸蛋白激酶途径作用与神经干细胞。

IGF-I was necessary for the proliferation of the nerve stem cells , which could affect the nerve stem cells through tyrosine protein kinase pathway .

目的探索酪氨酸蛋白激酶抑制剂Genistein对肝脏星状细胞（HSC）激活的抑制作用。

Objective To explore the effect of Genistein , a tyrosine protein kinase inhibitor , on inhibiting the activation of hepatic stellate cells ( HSC ) .

目的观察酪氨酸蛋白激酶抑制剂genistein对体外培养的正常人角质形成细胞增殖代谢的影响。

AIM To study the influence of tyrosine kinase inhibitor , genistein , on the proliferation , DNA synthesis and cell cycle of cultured human keratinocytes .

酪氨酸蛋白激酶（TyrosineProteinKinases，简称TPK）是一组酶系，催化ATP之γ-磷酸基转移到许多重要蛋白质的酪氨酸残基上。

Tyrosine Protein Kinases ( TPK ) constitute a family of enzymes that catalyze the transfer of phosphate from ATP to the hydroxyl group of tyrosine residue on many key proteins .

酪氨酸蛋白激酶（ProteinTyrosineKinase，PTK）是存在细胞膜或细胞浆中的蛋白激酶，它具有典型的羧基端催化区，当被激活后可以将其底物以及自身的酪氨酸残基磷酸化。

Protein Tyrosine Kinase ( PTK ) is a kind of kinase which exists in cellular membrane or cytoplasm . Having typical carboxyl-terminal , PTK can phosphorylate downstream molecules and also phosphorylate itself .

目的观察肿瘤坏死因子α（TNFα）对KM小鼠骨骼肌和肝细胞膜胰岛素受体酪氨酸蛋白激酶（TPK）活力的影响。

Objective To study the effects of TNF α on activity of TPK ( tyrosine protein kinase ) of the membrane insulin receptor of the muscle and liver in KM mouse .

目的探索肝硬化时肝组织细胞胰岛素受体（IR）和酪氨酸蛋白激酶（TPK）含量的变化规律。

Objective To investigate the relationship between the expression of insulin receptor ( IR ) and the content of tyrosine protein kinase ( TPK ) in patients with hepatic cirrhosis .

转化前后K-562细胞胰岛素受体酪氨酸蛋白激酶活性及内源性底物的研究

Comparative study of insulin receptor tyrosine kinase and its endogenous substrate in transformed and untransformed K-562 cells

应用图象分析系统对该12例肝细胞IR和TPK，进行抗胰岛素受体和酪氨酸蛋白激酶抗体免疫组化标记物定量测定。

The amount of IR and TPK have been evaluated by immunohistochemical quantitative analysis using image analyzer in hepatocyte of 12 patients positive for HBV markers with posthepatitic cirrhosis in serum .

脾酪氨酸蛋白激酶（Spleentyrosinekinase，Syk）是一种广泛表达在造血细胞、淋巴细胞、成纤维细胞、血管内皮细胞上的非受体蛋白质酪氨酸激酶，在细胞信号传导中起着重要的作用。

Spleen Tyrosine Kinase ( Syk ) is a non-receptor protein-tyrosine kinase . Its expression has been found in various cells such as the hematopoietic , lymphocyte , fibroblast and vascular endothelial cells .

FAK是一种非受体型酪氨酸蛋白激酶，是细胞存活，增殖，迁移以及侵袭等生物行为的重要调节分子，在胶质瘤细胞的侵袭中发挥重要作用。

FAK is a non-receptor protein-tyrosine kinase and functions as an important regulator in cellular processes such as cell survival , proliferation , migration and invasion .

c-Met属于受体酪氨酸蛋白激酶家族成员，常由上皮细胞（如肝、肾、消化道细胞）表达。

C-Met is one member of receptor tyrosine protien kinase family and often expresses in epithelial cell ( such as liver 、 kidney 、 enteron ) .

Src激酶家族是具有酪氨酸蛋白激酶活性的蛋白质。

Src kinase family have the activity of protein tyrosine kinase and play a pivotal role as a membrane-attached molecular switches that link a variety of extracellular cues to crucial intracellular signaling pathways .