血管性血友病因子

血管性血友病因子Ala737→Glu突变体的构建和表达

Construction and transient expression of an Ala 737 → Glu mutant of vWF

目的研究在流体切应力作用下表达突变的细胞与固着的血管性血友病因子（vWF）相互作用中GPⅠbα突变（A156V）的意义。

Objective To study the importance of glycoprotein ( GP )ⅰ b α mutation ( A156V ) in interaction between mutant expressing cell and immobilized vWF under fluid shear stress .

结果：高脂血症患者治疗前与正常对照组比较，血浆血管性血友病因子及C反应蛋白含量显著增高（P<0.05）；

The results were compared before and after treatment .

高甲硫氨酸诱发高同型半胱氨酸血症对抗凝血酶-Ⅲ，蛋白C和血管性血友病因子的影响

Effects of methionine-induced hyperhomocysteinemia on protein C , antithrombin - ⅲ and von willebrand factor

急性肺损伤血管性血友病因子、抗凝血酶-Ⅲ和蛋白质C的变化

Changes of von Willebrand factor , anti-thrombin - ⅲ and protein C in acute lung injury

人血管性血友病因子A1区单克隆抗体的制备和应用研究

Preparation and Application of Monoclonal Antibodies Against Human Von Willebrand Factor A1 Domain

目的探讨川崎病患儿血浆中血管性血友病因子（vWF）的临床变化及意义。

Objective To observe the variety and meaning in Kawasaki disease on plasma vWF .

测定两组血浆P-选择素、内皮素-1（ET-1）及血管性血友病因子（vWF）水平。

Plasma P-selectin , endothelin-1 ( ET 1 ) and von willebrand factor ( vWF ) were measured .

血管性血友病因子体外对胃癌细胞BGC-823增殖和黏附的影响

Effect of Von Willebrand Factor on Proliferation and Adhesion of Human Gastric Cancer Cell Line BGC-823 in Vitro

在术前、术后隔天检测血浆可溶性血栓调节蛋白（STM）和血管性血友病因子（vWF）含量。

Plasma soluble thrombomodulin ( STM ) and von Willebrand factor ( vWF ) levels were measured before operation and every other day after operation .

血管性血友病因子基因19内含子MspⅠ多态性与冠心病危险因素的关系

The relationship between von Willebrand factor gene Msp ⅰ polymorphism in intron 19 and risk factors for cardiovascular disease in Chinese

方法采用ELISA法测定58例恶性血液病病人及30例健康体检者血浆血管性血友病因子（vWF）、凝血酶调节蛋白（TM）、P选择素、D二聚体（DD）水平。

Methods The levels of von willebrand factor ( vWF ), thrombomodulin ( TM ), P selectin and D dimer in 58 malignant blood patients and 30 normal controls were measured by ELISA .

方法：利用双抗体夹心ELISA法测定血浆血管性血友病因子抗原vWF∶Ag，血小板膜表面α颗粒膜蛋白GMP140水平；

METHODS : The plasma levels of von willebrand factor ∶ antigen ( vWF ∶ Ag ) and granule membrane protein-140 ( GMP-140 ) were measured by double sandwich ELISA .

两组患者分别在入院当时及治疗第2、5、7d用ELISA法检测血浆血栓调节蛋白（TM）及血管性血友病因子（VWF），并与正常者比较。

Plasma thrombomodulin ( TM ) and von Willebrand factor ( vWF ) were both measured with ELISA in all patients on admission to hospital and on the 2nd , 5th , 7th day respectively .

目的：克隆和表达血管性血友病因子裂解酶（vWF-cp）的金属蛋白酶域。

AIM : To clone and express the metalloproteinase domain of human von Willebrand factor-cleaving protease ( vWF-cp ) .

通过重组幼仓鼠肾细胞（BHK细胞）在不同温度下的批培养和脉冲培养，研究了温度对重组BHK细胞生长、代谢以及血管性血友病因子（vWF）蛋白表达的影响。

Effects of temperature on the growth , metabolism and vWF expression of recombinant baby hamster kidney ( rBHK ) cells were investigated in batch and pulse cultures .

目的：观察超声治疗对急性脑梗死患者血浆α颗粒膜蛋白-140（GMP-140）、血管性血友病因子（vWF）含量及血液流变学的影响和促进神经功能恢复的作用。

Objective : To observe the effect of ultrasonic therapy on plasma contents of GMP-140 and vWF and hemorheology and the recovery of neurological function in patients with acute cerebral infarction ( ACI ) .

血管性血友病因子（VWF）是存在于血浆中的一种重要的止血相关蛋白，主要由血管内皮细胞和巨核细胞/血小板合成和分泌，在初期止血和二期止血中均发挥重要作用。

Von Willebrand factor ( VWF ), the largest human plasma protein , is synthesized and secreted by platelets and endothelial cells . VWF plays an important role both in primary hemostasis and in secondary hemostasis .

目的评价氯沙坦（Losartan，Los）治疗老年人轻、中度高血压病的临床疗效及对内皮素1（ET1）和血管性血友病因子（vonwillebrandfactor，vWF）的影响。

Objective To evaluate the efficacy of Losartan ( Los ) in the elderly with mild to moderate essential hypertension ( EH ) and its effect on endothelin 1 ( ET 1 ) and von willebrand factor ( vWF ) .

方法对3例TTP患者进行了血管性血友病因子（vWF）裂解蛋白酶活性分析，外周血涂片连续动态计数破碎红细胞百分率；

Methods vWF cleaving protease ( vWF CP ) activity in 3 cases of TTP was detected by Western blot . The percentages of fragmented red cells ( FRC ) were counted throughout the entire clinical course .

目的了解恶性肿瘤患者血清可溶性尿激酶受体（suPAR）、胸腺肽α1（Tα1）水平和血管性血友病因子裂解酶（vWFcp）活性水平与患者预后的关系并作比较。

Objective To investigate and compare the prognostic impact of serum solube urokinase receptor ( suPAR ), thymosin alpha 1 ( T α 1 ) levels and von Willebrand factor-cleaving protease ( vWF-cp ) activity in cancer patients .

目的通过对2例血栓性血小板减少性紫癜（TTP）患者诊疗经过的回顾及对血管性血友病因子裂解酶（vWF-CP）活性研究，以提高对TTP发病机制及治疗的认识。

Objective In order to improve the knowledge of mechanism and therapy in thrombotic thrombocytopenic purpura ( TTP ), we reported 2 cases of TTP and analysis the activity of von Willebrand fac - tor-cleaving protease ( vWF-CP ) .

目的测定脑梗死患者血浆中总蛋白S（TPS）、组织型纤溶酶原激活剂（t-PA）、血管性血友病因子（vWF）及纤维连接蛋白（Fn）含量，以探讨这些分子标记物与脑梗死之间的关系。

Objective To measure the concentration of total proteinS ( TPS ), tissue plasminogen activator ( t-PA ), von Willebrand factor ( vWF ) and fibronection ( Fn ) in plasma in patients with cerebral infarction and to investigate the relationship between those molecular markers and cerebral infarction .

目的检测2型糖尿病患者血浆血管性血友病因子裂解酶（vWF-cp）活性，探讨其在糖尿病血管并发症中的意义。

Objective To investigate the change of plasma von Willebrand factor cleaving protease ( vWF-cp ) activity level in patients with type 2 diabetes mellitus ( T2DM ) and to study its clinical significance in diabetes mellitus vascular complications .

血管性血友病因子在心脑血管疾病中的表现

Manifestation of the von Willebrand Factor in the Cardiovascular and Cerebrovascular Disease

实验性急性肺血栓栓塞症前列环素和血管性血友病因子的研究

Study on Prostacyclin and Von Willebrand Factor in Experimental Acute Pulmonary Thromboembolism

血小板内血管性血友病因子裂解酶表达的鉴定

Identification of von Willebrand factor-cleaving protease in peripheral platelets

不稳定型心绞痛病人血管性血友病因子与可溶性补体激活产物的变化

Changes of von Willebrand factor and complement component in patients with unastable angina

血栓调节蛋白和血管性血友病因子判断肝移植排斥反应的价值

Values of soluble thrombomodulin and von Willebrand factor judging reject reaction in liver transplantation

老年非瓣膜心脏病心房颤动患者血小板功能及血管性血友病因子的改变

Platelet function and endothelial cell disturbance in older non-valve cardiac patients with atrial fibrillation