血小板生成

人血小板生成因子（TPO）的cDNA克隆及促血小板生成效应

Cloning and expression of human thrombopoietin ( TPO ) cDNA and stimulative effect of thrombopoietin on platelet production

用脾切除术和新的促血小板生成药剂来治疗慢性ITP，这些也正在研究中。

Splenectomy and newer agents to boost platelet production are also under study in chronic ITP .

最近研究表明，血小板生成减少可能与ITP发生有关。

Recent evidences suggest that decreased platelet production may also contribute to the development of ITP .

血小板生成素（thrombopoietin，TPO）是调节血小板生成最主要的细胞因子，其生物学效应由其受体c－MPL介导。

Thrombopoietin ( TPO ) is the major cytokine which is involved in platelet production and exerts its effects via the receptor c MPL .

结论神经母细胞瘤患儿强烈化疗后IL-11用量在50μg/（kg·d）时可有效刺激血小板生成，升高外周血小板数量。

Conclusion Administration of interleukin 11 at dosage of 50 μ g / ( kg · d ) after intensified chemotherapy is capable of stimulating platelet production in children with neuroblastoma .

目的了解TPO模拟肽L203对骨髓抑制后大鼠的促血小板生成作用及对大鼠巨核细胞分化、增殖的影响。

Objeactive To research on TPO analogue peptide L203 to the thrombopoiesis effective and cultural megakaryocyte differentiation , the multiplication influence in myelosuppressive rats .

该公司已在美国推出血小板生成因子类药物promacta，每月药费3000美元，同时声称，相对于市场上已有的更昂贵竞争产品，该药存在治疗上的改进。

GSK has launched promacta , its platelet-boosting drug , at $ 3000 a month in the US , while arguing it represents a therapeutic improvement on more expensive rival products already on the market .

NFE2则主要参与晚期巨核细胞分化和血小板生成的调控。

NF E2 regulates late stage of megakaryocytopoiesis and platelet production .

血小板生成刺激因子对巨核血小板系统体外生成的影响

Stimulation of megakaryocyte maturation and thrombopoiesis in vitro by thrombocytopoiesis-stimulating factor

重组人血小板生成因子注射液的I期临床药代动力学

Phase I clinical pharmacokinetics of recombinant human thrombopoietin in healthy volunteers

γ线全身照射对小鼠血小板生成的影响

Effect of γ - ray TBI on thrombopoiesis in mice

结果生血宁能促进红细胞、白细胞及血小板生成；

Results Sheng xue ning can enhance erythropoiesis , leukocytopoiesis and thrombopoiesis ;

血小板生成素基因注射促血小板生成作用的实验研究

TPO gene injection promoted platelet production : a primary study

慢性肝病血小板生成减少的机制探讨

Elementary study of mechanis of decrease production of Platelet in patients with liver diseases

血小板生成因子的研究进展

Recent advances in platelet growth factors

巨核细胞集落生成单位血小板生成型巨核细胞

Colony-forming unit-megakaryocyte platelet-producing megakaryocyte

血小板生成素是一种调节血小板生成的新型细胞因子。

Thrombopoietin ( TPO ) is a novel cytokine that is involved in the regulation of platelet production .

结论生血宁治疗缺铁性与失血性贫血效果明显，促进红细胞、白细胞及血小板生成。

Conclusions Sheng xue ning shows significant effects on treating iron deficiency anemia and hemorrhagic anemia , enhancing erythropoiesis , leukocytopoiesis and thrombopoiesis .

研究结果：正常骨髓中的CD8~+T细胞不影响血小板生成和巨核细胞凋亡。

The depletion or addition of autologous CD8 + T cells from normal bone marrow did not affect apoptotic megakaryocytes and platelet production .

普鲁卡因胺对小鼠肺栓塞和血小板MDA生成的影响

Effect of procainamide on pulmonary thromboembolism and platelet

APT102是一种十分有趣的药物，它可以减少一种叫做ADP的物质，这种物质是由肿瘤细胞释放出来的，并可以促进血小板的生成。

APT102 is an especially interesting drug because it gets rid of a compound called ADP , which tumor cells release and which stimulates platelets to clump .

通过本研究，作者认为兔出血症的出血机制，可能与病毒直接对骨髓巨核细胞的损伤，导致血小板的生成障碍有关。

The authors considered that the pathogenic mechnism of rabbit hemorrhagic disease was related to marrow megalocaryocyte lesions and blood platelet dyspoiesis directly caused by the virus .

应用克山病病区低硒粮饲料喂养大鼠14周，探讨补硒（亚硒酸钠或硒酵母）对血小板血栓素生成的影响。

Rats were fed with selenium ─ deficient diet composed of grains from a Keshan disease endemic area for 14 weeks to investigate the effects of selenium supplementations ( as sodium selenite or selenium ─ yeast ) on the platelet TXA2 formation .

噻氯匹定对ADP诱导的血小板TXB2生成也有显著抑制作用。

It was also shown thai ticlopidine could significantly inhibit platelet TXB2 formation stimulated by adenosine diphosphate ( ADP ) .

槲皮素二硫酸酯二钠对猪血小板F-肌动蛋白生成的影响

Effect of Disodium Quercetin Disulfate on the Formation of F-actin in Pig Platelet Induced by Thrombin

电脉冲介导的Tpo基因转移对正常及实验性血小板减少小鼠的促血小板生成作用

Thrombopoietic effect of recombinant human thrombopoietin gene transferred to mice mediated by electric pulse on normal and experimental thrombocytopenia mice

本文研究证明，川芎嗪在体外对由诱导剂二磷酸腺苷、胶原、凝血酶诱导所致的家兔血小板聚集有强烈抑制作用，同时也能抑制血小板丙二醛的生成。

Our in vitro study proved that Ligustrazine could strongly inhibit platelet aggregation induced by adp , collagen , thrombin , and reduce the production of MDA from platelets ;

血小板生长因子（TPO）是巨核细胞系唯一的特异性生理性正调控因子。它可诱导造血干、祖细胞向巨核细胞系分化，促进巨核细胞的发育成熟及血小板的生成和释放。

Thrombopoietin ( TPO ) is a normal physiological hematopoiesis factor which is able to stimulate the hematopoietic progenitor cells to proliferate and differentiate into megakaryocytes and to induce the production and release of platelets .