蟾毒灵

蟾毒灵对人肝癌BEL-7402细胞增殖的影响

Effect of Bufalin on proliferation of BEL-7402 human hepatocarcinoma cell line

DSC曲线表明蟾毒灵使磷脂膜相变温度降低，吸热峰变宽。

DSC as a bulk method showed that bufalin lowered the main phase transition temperatrue and broadened the phase transition peak .

结果蟾毒灵对ECV304细胞的生长有抑制作用，且呈浓度和时间的依赖性。

Result Bufalin had inhibition growth effect on ECV304 cells with different level , and had concentration and time dependence .

蟾毒灵诱导肿瘤细胞凋亡机制的研究进展

Progress of research on the mechanism of Bufalin-induced apoptosis in tumor cells

蟾毒灵诱导肝癌细胞凋亡及相关机理研究

Study on the Apoptosis and Associated Mechanisms of Hepatoma Cells Induced by Bufalin

蟾毒灵诱导人急性早幼粒细胞性白血病细胞凋亡的实验观察

Observation on Effect of Bufalin on Inducing Cell Apoptosis in Human Acute Promyelocytic Leukemia

结论蟾毒灵具有明确的抑制血管内皮细胞增殖、抗血管生成的作用。

Conclusion Bufalin can inhibit the proliferation of vascular endothelial cell and has anti-angiogenesis effect .

另有报道证明蟾毒灵可以增加骨肉瘤和肝癌细胞对常规化疗药物的敏感性。

Other reports have proved that bufalin could increase the sensitivity of hepatic cancer and osteosarcoma cells to regular chemotherapeutics .

已有相关报道证明蟾毒灵可在肝癌、膀胱癌、子宫内膜癌等肿瘤细胞中引起细胞周期阻滞抑制细胞增殖活性。

There have been reports demonstrating that induction of cell cycle arrest is one of the most important mechanisms of bufalin in hepatic cancer , bladder cancer and endometrial cancer cells .

蟾毒它灵对人胃癌BGC-823细胞的促凋亡作用

Effect of Bufotalin on the Apoptosis of BGC-823 Cells

结论蟾毒它灵对BGC-823细胞有明显的促凋亡作用，其作用机理可能通过caspase-3凋亡途径实现。

Bufotalin promoted BGC-823 cell apoptosis and increased the level of activated caspase-3.Conclusion Bufotalin can induce the apoptosis of BGC-823 cells and its mechanism may be through caspase-3 pathway .