蛇床子素

其主要成分为乙酸龙脑酯、D-烯、丙酸香芹酯、蛇床子素、β-雪松烯、α-金合欢烯、α-蒎烯等。

The major chemical components were Bornyl acetate , D-Limonene , Carvyl propionate , Osthole ,β - Himachalene ,α - Farnesene and α - Pinene , etc.

方中厚朴酚、和厚朴酚、蛇床子素、欧前胡素及甘草酸为主要有效成分。

The principal active constituent is made up of Magnolol , Honokiol , Osthole , imperatorin and glycyrrhizic acid . The prescription has the effective of warming the kidney to improve inspiration , relieving cough and asthma .

超临界CO2萃取工艺对蛇床子素的影响

Influence of supercritical CO_2 extraction technology on osthol content from fruits of Cnidium monnieri

HPLC法测定妇洁洗液中蛇床子素的含量

Determination the Content of Osthole in FuJin Lotion by HPLC

蛇床子素也可降低酒精性脂肪肝大鼠肝组织中MDA含量（P＜0.01），显著升高高脂性脂肪肝肝组织中GSH-PX活性（P＜0.05或P＜0.01）。

In alcohol-induced fatty liver rats , level of MDA in liver was decreased ( P < 0.01 ) .

采用HPLC法对独活中蛇床子素和伞形花内酯建立含量测定方法；

HPLC is used to set up the determine method of Osthol in Tetrandra Root and umbel lectone .

结果：蛇床子素对新生大鼠颅盖骨成骨细胞的增殖、ALP的活性和胶原合成都有促进作用。

Results : Osthole significantly promoted osteoblast proliferation , alkaline phosphatase activity and collagen synthesis .

蛇床子素100mg/kg对致炎大鼠NOS活性有明显抑制效应，其水平接近空白对照组。

In the presence of Ost 100 mg / kg , NOS activities remained at near blank control levels .

结果：蛇床子素体外经皮渗透为零级过程，Q与t呈良好线性关系。

Result : The penetration process of osthole could be described by zero - order kinetics , linear relation of Q and T is good .

以豚鼠离体回肠和结肠带为标本，观察蛇床子素（Ost）的作用与Ca~（2+）的关系。

Effects of osthole ( Ost ) anti verapamil ( Vet ) were investigated in the isolated guinea-pig ileum and taeniae coli .

将三维荧光光谱技术用于药物经皮渗透研究，研究了OPA经离体皮肤渗透后皮肤不同皮层的蛇床子素的分布。

The innovative 3-D fluorescence spectra technology was applied to study the distribution of osthol in different skin layers after the isolated skin being treated with the osthol patches .

【结论】蛇床子素具有逆转T24/ADM细胞多药耐药性的活性，机制与OST抑制T24/ADM细胞膜P-gp蛋白表达有关。

【 Conclusion 】 Osthole has the reversal effect on Multidrug Resistance of T24 / ADM cell , the mechanism of reversion is related with down regulation of expression of P-gp .

材料与方法：体外蛇床子素对人肺腺癌细胞A549和人肝癌细胞Bel-7402的抗肿瘤实验采用MTT法，并计算IC50；

MATERIALS AND METHODS : In vitro , anti-tumor assay was performed with human pulmonary adenoma cells A549 and liver cancer cells Bel-7402 , MTT method was employed , and half-inhibitory concentration ( IC50 ) were recorded .

结果在体猪和兔耳静脉灌注模型在实验8h内灌注部位组织有较高生物活性，蛇床子素经在体兔耳皮肤吸收速率较在体猪耳大。

RESULTS It was indicated that the model was highly viable during the 8 hour perfusion . And the percutaneous absorption rate of osthol in the rabbit ear was higher than that in the pig ear .

采用醋酸氢化可的松肾阳虚小鼠模型，观察蛇床子素（osthol）和蛇床子总香豆素（TCR）对肾阳虚小鼠免疫功能的影响。

Mice were injected intraperitoneally with hydrocortisone acetate to replicate the animal model of Kidney Yang Deficiency ( KYD ) . Osthol and total-coumarins ( TCR ) from the fruit of Cnidium monnieri were administered orally to model mice .

结果在去卵巢大鼠模型上，蛇床子素10mg/kg和20mg/kg，可使血清TG和LDL-C/HDL-C比值明显降低，但对血清LDL-C仅有一定的降低作用。

Results In ovariectomized rat model , the serum TG and LDL-C / HDL-C ratio in the groups with doses of osthole at doses of 10 mg / kg and 20 mg / kg were depressed evidently , but the decrement of serum LDL-C level was not evident .

结论蛇床子素对AlCl3致急性衰老模型小鼠记忆障碍有保护作用，其作用机制可能是通过增强抗氧化酶GSHpx和SOD活性来清除氧自由基对中枢神经系统神经细胞的损伤。

CONCLUSION Osthol shows protective effect on brain memory impairment of mice in acute senile model induced by AlCl 3 . Perhaps the mechanism is involved in enhancing the activities of GSH-PX and SOD , clearing away the free radical , protecting the brain neuron from the harm of lipoperoxide .

YL-200中总香豆素的含量为7.31～8.09%，其中蛇床子素的含量1.16～1.18%，异欧前胡素的含量为1.04～1.19%。

The contents of total coumarins in YL-200 were 7.31 ~ 8.09 % , of them , osthol 1.16 ~ 1.18 % and isoimperatorin 1.04 ~ 1.19 % respectively .

蛇床子素对家兔主动脉条的钙拮抗作用

Calcium - antagonistic effects of osthole on isolated rabbit aortic strips

三维荧光光谱法测定蛇床子素在离体皮肤中不同深度的分布

Determination of Osthol in the Skin by Three Dimensional Fluorescence Assay

蛇床子素在正常与急性肾功能衰竭兔体内的分布研究

Distribution in vivo of osthole in normal and renal failure rabbits

蛇床子素抑制血栓形成和血小板聚集的实验研究

Experimental study of osthole on inhibition of thrombosis and platelet aggregation

1%蛇床子素粉剂对三种储粮害虫的防效

Control effect of 1 % Osthol powder to three stored-grain pests

蛇床子素的结构修饰与钙拮抗活性研究

Studies on Semi-Synthesis of Osthol Derivatives and Their Calcium Rivalry Activities

蛇床子素抗心律失常作用实验研究

Experimental Studies on the Anti - arrhythmia Effects of Osthol

蛇床子素在老年性痴呆模型大鼠血浆的药代动力学研究

Pharmacokinetics of osthol in plasma in rats of Alzheimer 's Disease model

蛇床子素水醇凝胶治疗亚急性湿疹的临床疗效观察

Clinical Efficacy of Hydroalcoholic Gel of Osthol for Subacute Eczema

目的：测定血浆中蛇床子素的浓度。

Objective : To measure the content of Osthole in blood plasma .

天然化合物蛇床子素防治草莓白粉病

Control of Strawberry Powdery Mildew with the Natural Compound Osthol

蛇床子素的药理作用和作为生物农药的研究

Pharmacological Effects and Research of Osthole as a Biological Pesticide