药物疗效

增加干扰素β-1a剂量和频率治疗复发性多发性硬化症提高药物疗效的EVIDENCE研究

Enhanced benefit of increasing interferon beta-1a dose and frequency in relapsing multiple sclerosis : The EVIDENCE study

目的：建立用于评价药物疗效的较理想的Hp相关性慢性胃炎大鼠模型。

Objective : To establish a better rat model of H.pylori-associated chronic gastritis .

SD大鼠哮喘模型中平喘药物疗效观察

Observation of the effect of anti-asthmatics on asthmatic animal model of SD rat

HBV-DNA载量测定是反映HBV复制和判断药物疗效的最直接、可靠的指标。

Quantitative detection HBV - DNA is a direct , reliably index .

采用简易智力状态检查表（MMSE）和长谷川痴呆量表（HDS）对药物疗效进行评价。

MMSE and HDS were used to evaluate the therapeutic efficacy .

临床上利用双能X射线骨密度测量仪测定骨矿密度来判断药物疗效等课题设计时，要参考骨质疏松的严重程度及不同条件病例对样本规模有一个正确估计。

Quantitative detection sample size should be estimated correctly when measuring the changes of BMD with Dual-energy X-ray bone densometer in determining the therapeutic effects of drugs .

QTd对于抗心律失常药物疗效无预测价值。

QTd cannot predict the efficacy of ventricular arrhythmia treatment .

目的建立胶原诱发关节炎（CIA）的DBA/1小鼠模型，对其发病特点、临床表现特征及病理学变化分别予以分析，为相关药物疗效评价提供合适模型。

Aim To establish a collagen-induced arthritis ( CIA ) model in DBA / 1 mice and explore its characteristics .

恶唑酮小鼠结肠炎模型可作为研究UC发病机制和评估药物疗效的有益工具。

It is concluded that the oxazolone-induced mice colitis model is useful for the study of the pathogenesis of UC and the evaluation of the drug efficacy .

应用分级诊断标准可为科学研究OP及临床观察药物疗效，提供具体客观指标及科学依据；

The adopting of classification diagnoses criteria will provide scientific , objective , concrete index and grounds for researching OP and estimate OP medicine curative effect in clinic .

为CT机应用增加了新的功能，为骨质疏松症的检查诊断、预防治疗和药物疗效的观察提供了新的准确可靠的方法。

The system adds to the new applications of CT systems , and provides a new method with a good accuracy and reliability for the examination , diagnosis , prevention , treatment of osteoporosis diseases and the observation of curative effect of drugs .

结论：疏血通注射液对急性缺血性脑卒中的微栓子具有预防和治疗作用；TCD栓子自动监测有助于及时发现微栓子、评估药物疗效。

CONCLUSION : Shuxuetong injection has preventive and therapeutic effects on MES of AIS , TCD automatic embolus monitor helps to find MES in time and evaluate the effect of drugs .

从药物疗效来看，虫类中药有效率略高于对照组，两组无显著性差异（P0.05）。

The two groups showed no significant side effects occurred . Insects Chinese medicine from the efficacy point of view , efficiency is slightly higher than that in the control group , there was no significant difference ( P0.05 ) .

5-HT（2C）受体基因多态性与首发精神分裂症患者抗精神病药物疗效的关联分析4种非典型抗精神病药物对精神分裂症患者血糖及血脂代谢的影响

Association of 5-TH_ ( 2C ) Receptor Genes Polymorphism with Therapeutic Response to Antipsychotic Drugs in First-episode Schizophrenia ; Effects on Lipid and Glucose Metabolism among Four Different Atypical Antipsychotics Agents

目的研究检测尿I型胶原交联氨基末端肽（NTx）监测抗骨吸收药物疗效的作用。

Objective To investigate the effect of urine NTx in monitoring the effects of treatment osteoporosis with anti resorption drugs .

结论：dti可定量分析左室壁心肌收缩与舒张功能为临床观察药物疗效、合理选择药物及预后判断提供了定量指标。

Conclusion : dti can analyse quantitively the systolic and diastic Caidiac function of left ventricle and provide quantitive standards fox clinical drug effects observation , selection of drugs and prognosis of treatment .

针对TP的靶向性抗血管新生治疗是个体化性的，根据TP的表达情况可预测化疗药物疗效并选择合理的治疗，改善并提高高表达TP患者的预后。

The anti-angiogenesis therapy targeted to TP is individual and knowing the expression of TP has a guide role in judging the prognosis , therapy response and establishing reasonable treatment strategy in order to improve the prognosis of the patients .

伊林特肯（CPT-11）对肺癌细胞的细胞毒作用、药物疗效预测及羧酸酯酶同工酶对伊林特肯增效作用的探讨

Investigation to the Cytotoxity of Irinotecan ( CPT-11 ) to Lung Cancer Cells , Prediction Method of Curative Effect and the Activation of Carboxylesterase Isoenzymes to Irinotecan

目的：对维持性血液透析（MHD）患者肾性贫血和健康相关生存质量进行研究，为其预后判断、药物疗效的分析及药品经济学评估提供依据。

Objective To investigate renal anemia and health-related quality of life ( HRQL ) among maintenance hemodialysis ( MHD ) patients and to provide evidences for the prognostic judgement , pharmacodynamic analysis and physic economic evaluation on this population .

K562细胞株系人CML急性变细胞株，既具有急性白血病的细胞生物学行为，又具有CML细胞特有的本质，因此是体外研究筛选抗白血病药物疗效及机制的良好细胞模型。

K562 cell line originated from human CML cells with blastic transformation * Because of the character of acute leukemia cells and the specific essence of CML cells , K562 cells are a good study model for researching anti-leukemia drug .

胎儿平均体重（242±049）kg，平均Apgar评分≥8分。结论在抑制宫缩治疗中利托君介导的孕妇心率增加可作为评价药物疗效的指标之一。

Average fetal weight was ( 2 42 ± 0 49 ) kg , and the average Apgar 's score was ≥ 8.Conclusion In the treatment of inhibiting uterine contractions , the increasing of maternal heart rate caused by ritodrine can be used as an indicator of therapeutic effect .

结论LAP-SLN和LAP-GSLN在体内具有良好的肝靶向性，对提高药物疗效，减少用量，降低毒副作用有一定意义。

Conclusion Both LAP-SLN and LAP-GSLN showed a good liver-targeting efficiency in vivo , which may reduce the side effects of LA , decrease dose and improve its efficacy .

培美曲塞（Alimta）是美国FDA2004年批准上市的抗代谢类抗肿瘤药。其作用机制是对叶酸代谢途径的多靶点阻断，因此，药物疗效高于其他抗叶酸类药物。

Pemetrexed ( Alimta ) is an antifolate drug approved by American FDA in 2004.As It can disrupt folate-dependent metabolic processes by multi-targets , the response rates are higher than other antifolate drugs available in clinical use .

背景与目的近年的研究结果显示COX2抑制剂具有抑制肿瘤生长、增强化疗药物疗效的作用。NS398是一种选择性COX2抑制剂，可抑制肺癌细胞的增殖并增强化疗药物的疗效。

Background and objective In recent years , many investigations have showed that COX-2 inhibitors not only inhibit the growth of tumor cells but also enhance the cytotoxicity of anticancer drugs , such as NS-398 , a selective COX-2 inhibitor .

常规化疗药物疗效预测分子与化疗选药

Routine Chemotherapeutic Drug Treatment Effectiveness Predictive Molecules and Chemotherapeutic Drug Selection

药物疗效与剂量呈正相关，腹腔给药优于口服给药。

Intraperitoneal administration of the drug was superior to oral one .

高血压合并高血脂治疗药物疗效及安全性监测

Efficacy and safety supervision in a hypertensive patient combined with hyperlipidemia

全民食用加碘盐对甲状腺机能亢进病人药物疗效的影响

Effect of universal salt iodization on the dosage of antithyroid drug

排除的146篇是重复的同一药物疗效研究。

The excluded were 146 papers of repeated drug effect study .

强电脉冲治疗肿瘤提高抗癌药物疗效的研究

Study of High-intensity Electric Pulse Inhibited Sarcoma for Improving Antitumor Drug Effect