致突变作用

人脐血造血干/祖细胞对裸鼠的致突变作用

Mutagenic Action of Hematopoietic Stem / Progenitor Cells from Human Umbilical Cord Blood in Nude Mice

通过清洁级昆明种小鼠骨髓嗜多染红细胞微核试验和染色体畸变试验，探讨了促性腺素释放素类似物5号（GnRH-A5）的致突变作用。

To study the mutagenic action of GnRH-A_5 , the mouse PCE micronucleus test and chromosomal aberration analysis were done .

多环芳烃DNA加合物致突变作用研究

Studies on Mutagenicity of Polycyclic Aromatic Hydrocarbon DNA Adduct

非程序DNA合成法评价厨房油烟凝聚物致突变作用

The assessment of mutagenicity of cooking oil fume condensate in kitchen by uds-test

亚硒酸钠和维生素E抗香烟烟雾的致突变作用

Effects of Sodium Selenite and Vitamin E Antagonizing Mutagenesis Caused by Cigarette Smoke Condensate

运用RAPD技术检测除草剂对草鱼的致突变作用

Detection on Mutagenicity of Herbicides to Grass Carp by RAPD Technique

研究表明这种突变是在DNA或DNA的转录水平上发生的。用S1可以简便、快速、灵敏地检测出EB的致突变作用。

The mutagenesis of EB could be detected with S1 dark variant , and this method was simple , rapid and sensitive .

硫芥的毒物动力学Ames试验检测硫芥的致突变作用

Study on mutagenicity of sulfur mustard by Ames test

微核、精子畸形和Ames试验表明无致突变作用。

Micronucleus assay , sperm deformity assay and Ames assay are not mutagenesis ;

目的：观察转基因细胞SPC－A－1／IL－2的致突变作用，为转基因肿瘤细胞作为瘤苗进行临床应用的安全性检测提供依据。

Objective : To investigate the safety of transgenic human lung adenocarcinoma cell line SPC-A-1 / IL-2 as tumor vaccine .

结果：转基因细胞SPC－A－1／IL－2的DNA及培养上清液均未显出致突变作用。

Results : The result indicated that mutagenesis of both the DNA and the supernatant of transgenic cell SPC-A-1 / IL-2 was not observed .

分窝（2,3,3天）实验也表明TNT对果蝇各阶段生殖细胞的致突变作用相同。

TNT has the same mutagenicity to the germ cell of different period ( 2,3,3 day ) .

小白鼠骨髓PCE微核试验结果也显示对小鼠无致突变作用。

Mini-caryon tests of marrow PCE showed that it has no mutagenicity effect about mice yet .

目的：研究猕猴桃果汁抗环磷酰胺（CP）的致突变作用及其可能的作用机制。

Objective : To observe the effect of kiwifruit juice on the mutagenicity induced by cyclophosphamide ( CP ) and the antioxidative mechanism in rats .

作者应用外周血姐妹染色单体交换率（SCE）技术估价多菌灵A的致突变作用。

The authors used technique of sister chromosome exchange ( SCE ) to assess the effect on mutation with BCMA .

rhEPO注射液致突变作用研究

The study on mutagenicity of rhEPO injections

在非整倍体检测实验中，X或Y染色体丢失率明显增加，也有明显的剂量反应关系。说明TNT对果蝇生殖细胞具有明显的致突变作用。

In aneuploidy detection test TNT did not induce X and Y chromosomal nondisjunction , but induced the loss of X or Y chromosome with a good dose-response relationship .

方法：采用修改的Ames试验，研究松茸提取物PME对强致癌物B（a）P致突变作用的影响。

METHODS : The antimutagenic effect of PME on benzo - ( a ) - pyrene ( B ( a ) P ) was studied by the revised Ames test .

多环芳烃（PAHs）是一类重要的环境污染物，其中大部分具有致癌、致畸和致突变作用。

Polycyclic aromatic hydrocarbons ( PAHs ) represent an important class of environmental pollutants , of which most are known to be carcinogenic , teratogenic and mutagenic .

以微核（MN）试验和淋巴细胞非特异性酸性萘酯酶（ANAE）染色法观察了不同浓度亚硒酸钠溶液对环磷酰胺（CP）致突变作用及对小鼠免疫细胞活性的影响。

Inhibitory effects on the mutagenic activity of cyclophosphamide and immune influences of selenium in different concentrations were observed with micronucleus test and ANAE staining in mice .

结果：风湿平Ames试验、小鼠骨髓细胞微核试验结果均为阴性；CHL细胞染色体畸变试验结果为阳性，经过S9代谢活化后致突变作用降低。

Results : The results of Ames and micronucleus tests were negative , but the result of chromosome aberration test was positive .

材料与方法：采用修改的Ames试验，研究真菌植物松茸提取物AMH（AntimutagenicHerb）对卷烟焦油致突变作用的影响。

MATERIAL AND METHODS : The antimutagenic effect of AMH ( Antimutagenic Herb ) on CSC was studied by the revised Ames test .

目的与方法：本文通过Ames试验和SOS显色试验比较了环磷酰胺（CP）与异环磷酰胺（IFO）的致突变作用。

Purpose and Methods : The mutagenicity of Cyclophosphamide ( CP ) and Ifosfamide ( IFO ) was studied using Ames test and SOS chromotest .

方法用Ames试验、胞质阻断微核试验（CBMN）及彗星试验（cometassay）检验Q流域地面水14个地面水样品的致突变作用。

Methods The mutagenicity of 14 samples from Q river surface water were detected by the method of Ames test , cytokinesis-block micronucleus test and comet assay .

天然植物制剂AMH体外抑制多种强致癌物的致突变作用

The inhibitory effect of the natural plant extract AMH on the mutagenicity of several carcinogens in vitro

本文采用原位缺口翻译技术，液闪计数测定，观察了兴安升麻总皂甙拮抗诱变剂丝裂霉素C（MMC）对人外周血细胞的致突变作用。

The antimutagenic effect of the total saponins of Cimicifuga dahurica on mutagenicity of normal human peripheral blood cells induced by MMC were quantitatively detected by using in situ nick translation method and liquid scintillation counting .

目的研究三苯基铋（TPB）的亚急性毒性、蓄积毒性和致突变作用，为其在固体推进剂中的应用及防护提供毒理学依据。

Objective To study the sub-acute toxicity , cumulative toxicity and mutagenicity of triphenyl bismuth ( TPB ) in mice .

大蒜提取液对ENNG和MNU致突变作用的抑制效应研究

Repressive effect of the extraction of garlic to the mutagenicity of ENNG and MNU

采用鼠伤寒沙门氏菌回复突变试验（Ames试验）、小鼠骨髓多染红细胞微核试验、小鼠睾丸精母细胞染色体畸变试验、V79细胞基因突变试验来检测有无致突变作用。

The Ames test , Erythrocyte micronucleus assay , Spermatogonial chromosomal aberrations test and In vitro mammalian cell gene mutation test were used .

目的与方法：本文研究顶体蛋白酶抑制剂KF-950对小鼠的急性毒性作用，以及Ames试验观察其致突变作用。

Purpose and Methods : The acute toxic and mutagenic effects of acrosin inhibitor KF-950 were evaluated in mice and Ames assay .