致癌作用

DNA加合物的致癌作用研究进展

Progress of Studying Carcinogenesis of DNA Adducts

综述了遗传毒性化学物质与DNA的加合作用，以及DNA加合物形成后在致癌作用中的影响。

Review on combination of genotoxic chemicals with DNA and the effects of DNA adduct formation on carcinogenesis were presented .

丙型肝炎病毒核心蛋白致癌作用的研究B和C基因型HBV核心蛋白促细胞凋亡的比较

Comparison of effect on hepatocellular apoptosis between core proteins of hepatitis B virus genotype B and C

所有HCV感染者均伴有HBV感染，二者可能有协同致癌作用。

All patients with HCV infection were overlapped with HBV infection .

结论镉诱导毒性和致癌作用的影响可能涉及能量代谢、防御保护、DNA修复多个方面；

CONCLUSION : The cadmium-reduced toxicity carcinogenic effects involved energy metabolism , defense mechanisms and DNA repair of the cell .

HBV－NC1株X基因在真核细胞中表达，基因调控与致癌作用的初探

Study on the Expression in Eukaryote Cell , Gene Regulation Effect and Carcinogenesis of the HBV X Gene

蕨粉的实验研究I.蕨粉致癌作用的实验研究

The Experimental Research on Fern Powder ⅰ

DON与NOC对胃组织致癌作用的实验研究

Carcinogenic effects on gastric tissues caused by DON and NOC

目的：探讨草苁蓉（BR）对大鼠肝脏化学致癌作用的抑制效应。

Objective : To investigate the inhibitory effect of Boschniakia rossica ( BR ) on hepatocarcinogenesis in rats .

乙肝病毒X蛋白通过与survivin和HBXIP形成复合物发挥致癌作用

Hepatitis B Virus X Protein Leads to Carcinogenesis by Forming a Complex with Survivin and HBXIP

目的观察胡麻油烟凝聚物（SOFA）对人胚肺二倍体细胞增殖及DNA含量的影响，为研究胡麻油烟潜在致癌作用提供实验依据。

Objective To study the influence of siritch oil fume aggregates ( SOFA ) on the proliferation and cell cycle of human embryo lung diploid cell .

T-2毒素对小鼠致癌作用的病理形态学观察

Pathomorphological observation on carcinogenicity of T-2 toxin in mice

目的：探讨幽门螺杆菌HP引起胃粘膜上皮细胞凋亡和增殖改变及HP致癌作用的可能机制。

Objective : To investigate the bcl-2 and bax protein expression and its association with apoptosis and cell proliferation in Helicobacter pylori ( HP ) related gastritis .

目的检测二氯乙酸和三氯乙酸对大鼠p53基因的DNA损伤作用，证实其遗传毒性并探讨其致癌作用的分子机制。

Objective To study on the DNA damage of p53 induced by dichloroacetic acid ( DCA ) and trichloroacetic acid ( TCA ), approve their genotoxicity and discuss molecular mechanism of their carcinogenic action .

目的对应用表面化学着色工艺研制的彩色正畸不锈钢弓丝进行鼠伤寒沙门氏菌回复突变试验（Ames试验），研究材料是否具有遗传危害和潜在的致癌作用。

Objective To study the potential mutagenicity of colored stainless steel applying chemical coloration technology for orthodontic wire by Ames test .

染色体4q21≈23等位基因丢失与HBV相关致癌作用以及甲胎蛋白升高相关

Allelic loss of chromosome 4q21 ≈ 23 associates with hepatitis B virus-rel ated hepatocarcinogenesis and elevated alpha-fetoprotein

世界卫生组织（WorldHealthOrganization）的国际癌症研究机构（InternationalAgencyforResearchonCancer）基于人和动物身上的有限证据，将手机辐射列为“可能”对人类有致癌作用的物质，与咖啡和咸菜属于同一级别。

The International Agency for Research on Cancer , part of the World Health Organization , rates cellphone radiation a " possible " " human carcinogen , based on limited evidence in both people and animals . It gives the same rating to coffee and pickled vegetables .

文中讨论了PCBs对人类健康的影响，阐述了人体暴露于PCBs污染可能存在致癌作用，影响内分泌和生殖系统，以及刺激皮肤等。

The influence of PCBs upon human health has been discussed in this article . The health risks of exposures to PCBs include carcinogenic effects , endocrine effects , reproductive effects and dermal effects .

邻苯二甲酸二辛酯（DOP）被美国癌症研究所（NCI）怀疑有致癌作用后，其使用范围受到限制。

After DOP was suspected that there was carcinogenic function by the cancer research institute of U. S. A. ( NCI ), its scope of application was limited .

其中，Cr（Ⅵ）毒性极强，对人体有致畸致癌作用。目前，利用生物和矿物材料（铝硅酸盐矿物、碳酸盐矿物和铁的氢氧化物等）去除重金属是研究者们关注的热点。

And Cr (ⅵ) is most toxic and carcinogenic to organism . Presently , it is hot topic noticed by researchers that the biology and mineral materials such as alumino-silicates minerals , carbonate minerals and iron oxyhydroxides , are utilized to remove the heavy metals .

DCNPA的遗传毒作用／致癌作用需要哺乳动物体内活化；

The metabolic activation in mammalian was needed for the genotoxicity / carcinogenicity of DCNPA ;

目的研究胃癌组织中HPV16的感染及p21基因突变是否存在协同致癌作用及其与胃癌患者预后的关系。

Objective : To investigate whether there is a synergistic carcinogenesis between the infection of human papilloma virus ( HPV ) and the P21 gene mutation in gastric cancer tissue and their relationship with prognosis of the patients with gastric cancer .

为探明人乳头状瘤病毒（HPV）和促癌剂对食管上皮致癌作用，人胚食管上皮细胞转染HPV协同60钴（60Co）放射观察其恶性转化。

To explore the effect of human papillomavirus and tumor promoter on the tumorigenicity of esophageal epithelium , the human embryonic esophageal epithelial cells were infected with human papillomavirus ( HPV ) in synergy with ~ ( 60 ) cobalt radiation to observe their malignant transformation .

石油沥青致突变和致癌作用的实验研究

Experimental Research of the Carcinogenic and Mutagenic Effects of Petroleum Asphalt

这是因为在致癌作用的石棉粒子。

This is because of the carcinogenic effect of asbestos particles .

结论颗粒状铁石棉粉尘具有致癌作用。

Conclusion Amosite granular dust has the effects of causing carcinoma .

但是臭氧氧化后会产生具有致癌作用的溴酸盐副产物。

But ozonation will generate bromate , a by-product which is carcinogenic .

已被认为对人类有致癌作用的物质。

Substances which are known to be carcinogenic in humans .

幽门螺杆菌的致癌作用尚不清楚。

The mechanism of H.pylori induced carcinogenesis is not clear .

白僵菌对小白鼠致癌作用的实验研究

An experimental study on the carcinogenic effect of Beauveria bassiana in mice