胰岛细胞

胰岛细胞移植治疗成人Ⅰ型糖尿病的临床应用初探

Application of Pancreatic Islet Cell Transplantation in Diabetes Patients

胰岛细胞瘤的CT诊断（附12例分析）

CT Diagnosis of Islet Cell Tumor of the Pancreas ( Analysis of 12 Cases )

多层螺旋CT对无功能性胰岛细胞瘤与胰腺癌的鉴别

Non-functional Islet Cell Tumor : Differentiation from Pancreatic Cancer at MSCT

恶性胰岛细胞肿瘤很少产生第X因子。

Some benign insulinomas also presented factor X-like antigen .

前列腺素E2对四氧嘧啶处理的新生大鼠离体胰岛细胞内环核苷酸含量变化的影响

Effect of pge_2 on cyclic nucleotide content of isolated neonatal rat pancreatic islets treated with alloxan

Bcl-2对免疫抑制剂培养中胰岛细胞的保护作用

Study on protection of Bcl-2 on islet cells cultured in immunosuppressive drugs

铜对体外培养的仔猪胰岛细胞SS分泌的影响

Effection Of Copper On Porcine Pancreas Islet Cell Excreting SS In Vitro Culture

采用一种简单高效的互补脱氧核糖核酸（cDNA）克隆技术制备人胰岛细胞瘤的cDNA文库。

A cDNA library of human insulinoma was constructed by using a highly efficient and simplified cDNA cloning method .

Fas配体阳性睾丸细胞和环孢素A对移植胰岛细胞存活起协同保护作用

Synergetic protective effect of testicular cells expressing Fas ligand and cyclosporine A on the survival of islet allografts

胰腺外分泌部由浆液性腺泡组成，胰腺内分泌部胰岛细胞电镜下主要分为三种：A细胞、B细胞和D细胞。

Exocrine pancreas is made up of serous cells . Observed by transmission electron microscope pancreatic island is made up of three kinds of cells : A cell , B cell and D cell .

结论无功能胰岛细胞瘤症状缺乏特异性，Bus及CT应为首选的检查方法。

Conclusions Non-functional islet cell tumor lack specificity , Bus and CT are primary examination methods , immuno-histological analysis indicates various different hormones , but lacks the presence of related clinical symptoms .

结论实验结果可能反映了DM合并感染时扩大的炎症反应和胰腺损伤，可能潜在着胰岛细胞凋亡与TNF-α的正相关性。

Conclusion The study may reflect amplified inflammation reaction and function impairment of islet , especially in the rats with DM complicated infection .

STZ处理的大鼠胰岛细胞CSD基因的相对表达量下降。

The relative CSD gene expression in islet cells treated by STZ decreased . 3 .

结论他克莫司对体外培养的大鼠胰岛细胞有直接的损害作用，而Bcl-2能防治这种损害作用。

Conclusion Tacrolimus may directly damage to isolated rat islet cells and the expression of Bcl-2 can protect the cells from the damage of immunosuppressive drugs .

早期应用胰岛素治疗有助于保护部分LADA患者残存的胰岛细胞功能。

Early insulin intervention may preserve residual islet beta-cell function in LADA .

应用定量RT-PCR（QRT-PCR）检测培养后大鼠胰岛细胞和小鼠βTc3细胞bcl-2和BAXmRNA的表达；

MRNA expressions of bcl-2 and bax of cultured rat islet cells and mouse β Tc3 cells were detected by QRT-PCR .

在STZ破坏胰岛细胞，自身抗原存在的同时，导致了自身免疫糖尿病的发生。

STZ destroys insulin and existence of self-antigen , meanwhile , results in the occurrence of autoimmune diabetes mellitus .

采用AOPI双染色法对两组培养3d、7d、14d的胰岛细胞存活率进行检测；

Survival rate of islets cultured for days 3 ? 7 ? 14 in stationary flasks or microgravity bioreactors was measured by AO-PI double-staining .

和对照组相比，高糖组胰岛细胞凋亡率显著增加（P＜0.05）。脂联素干预治疗可使细胞凋亡率显著下降（P＜0.05）。

Compared with the control group , the number of apoptosis cells in the high glucose treated group were significantly increased than the control group ( P0.05 ), but it significantly decreased with adiponectin intervention ( P 0.05 ) . 5 .

胰岛细胞凋亡过程中，诱导凋亡基因bax的mRNA表达水平明显升高，抵抗凋亡基因bcl-2mRNA表达水平明显下降，致使bcl-2/bax比率明显降低；

MRNA expression of apoptosis-induced gene bax increased significantly and that of apoptosis-resistant gene bcl-2 decreased significantly in the islet cell apoptosis process , and bcl-2 / bax ratio decreased significantly .

目的免疫组化技术检测胰岛细胞抗体（ICA）是临床对糖尿病的诊断、分型、预测的重要免疫学指标之一。

Objective : ICA detected by immunohistochemical technique is one of the important index for the clinical diagnosis 、 classification and prognosis of the diabetes mellitus .

目的：研究和探讨1,25-（OH）2D3对于STZ诱导的大鼠离体胰岛细胞损伤的影响及其可能的作用机制。

OBJECTIVE : In this study we investigated the effect of 1,25 - ( OH ) 2D3 on streptozotocin-induced damage to rat pancreatic islet cells .

方法用胶原酶P两步法消化分离胰腺，用试管法通过不连续密度梯度HC-A-Ficoll纯化液纯化人胰岛细胞。

Methods Pancreata was enzymatically digested by two-step digestion method and purified by discontinuous gradient centrifugation on four layers of HC-A-Ficoll solutions by tube method .

NO-1886对培养的胰岛细胞凋亡和β细胞功能的影响

Effect of NO-1886 on cultured islet cell apoptosis and β - cell function

其作用机制可能是与其通过促进GLP-1分泌进而促进胰岛细胞增殖有关。

One of DC treatment mechanisms is associated with its enhanced the islet cell proliferation by increasing the incretion of GLP-1 .

目的研究甘油三酯（triglycerides，TG）对胰岛细胞的作用，并探讨NO1886对TG诱导的胰岛细胞凋亡的作用和对胰岛β细胞功能的作用。

AIM To elucidate the effect of triglyceride on the cultured islet cells and study the effect of NO 1886 on triglyceride induced islet cells apoptosis and the function of islet cells .

结论①新生儿及婴幼儿期反复出现抽搐、低血糖症状要考虑由于胰岛细胞增生所致的高胰岛素血症，需作血糖胰岛素比值测定及B超、CT检查排除胰腺占位性病变；

Conclusions ( 1 ) When convulsion and hypoglycemia occurred frequently in newborns and infants , hyperinsulinemia caused by nesidioblastosis should be considered . The ratio of blood glucose and insulin should be examined and B-mode ultrasound and CT performed to exclude space-occupying lesions of pancreas .

方法：应用TUNEL法检测高浓度葡萄糖培养后大鼠胰岛细胞和小鼠βTc3细胞凋亡百分率；

Methods : Apoptosis percentages of primary rat islet cells and β Tc3 cells cultured with high concentration glucose medium were measured by TUNEL method .

目的：探讨在2型糖尿病患者中联合检测谷氨酸脱羧酶抗体（GADA）和胰岛细胞自身抗体（ICA）的临床意义。

Objective : To study clinical significance of glutamic decarboxylase autoantibody ( GADA ) and islet cell cytoplasm autoantibody ( ICA ) in type 2 diabetes mellitus .

结果胰腺与肾脏经HC-A液原位灌注满意，胰岛细胞的活性与冷缺血时间呈负相关，冷保存指数和胰岛细胞活性呈正相关。

RESULT Activity of islets and the cold ischemia preservation time is in a negative correlation ;