肺炎链球菌感染

在实验室检查方面，单纯Q热柯克斯体感染患者血小板计数明显较肺炎链球菌感染患者高（p<0.05）；

In experiment examination , purely Q fever infection patients have a higher blood platelets counts ( p < 0.05 ) .

肺炎链球菌感染早期外源性白介素-18干预的实验研究

Experimental Research on Interference of Exogenous IL-18 in Early Stage of Streptococcus Pneumoniae Infection

肺炎链球菌感染性疾病在世界各地均导致很高的发病率和死亡率。

SP is the common cause of bacterial pneumoniae , and pneumococcal infectious diseases are the causes of high morbidity and mortality worldwide .

目的评价儿童流行性感冒人群中肺炎链球菌感染及耐药性，为临床提供准确可靠的诊疗依据。

OBJECTIVE To evaluate the state of Streptococcus pneumoniae infection in children with influenza , and to provide accurate and reliable basis for clinic .

感染模型建立是实验研究的基础，目前建立成年小鼠肺炎链球菌感染模型方法已经成熟，但是如何建立新生期小鼠非致死性肺炎链球菌感染模型的方法尚未见报道。

Establishment of adult mice to Streptococcus pneumoniae infection model is ripe , but how to create a model of neonatal mice non-letha S.pneumoniae infection has not been reported .

阿莫西林或阿莫西林/克拉维酸是临床治疗肺炎链球菌感染常用药物，尤其是儿科在治疗呼吸道感染的常用口服药物，所以本部分研究选取阿莫西林作为评价药物选择压力用药。

Amoxicillin and amoxicillin / clavulanic acid are commonly-used antibiotics in the treatment of pneumococcal infections , especially paediatric respiratory tract infection . Therefore , amoxicillin was selected to evaluate antibiotic selective pressure .

第二部分新生期肺炎链球菌感染对小鼠成年后哮喘影响的实验性研究支气管哮喘，是儿童最常见的慢性呼吸道疾病，其本质是气道的慢性炎症，其病理变化与免疫系统的情况密切相关。

PART TWO : EARLY-LIFE PNEUMOCOCCAL INFECTION LUNG INFECTION ENHANCES ALLERGIC AIRWAYS DISEASE THROUGH TH17 / IL17Bronchial asthma is the most common chronic respiratory disease in children . Its nature is a chronic inflammation of the airways . The pathological change of asthma is closely related with immune system .

目的了解肺炎链球菌在呼吸道感染患者和健康儿童中的分离率及对抗菌药物的耐药性。

Objective To investigate the prevalence of Streptococcus pneumoniae in patients with respiratory tract infection and healthy children and to determine the antibiotic susceptibility in S.pneumoniae .

目的：分析天津市10家医院近3年来肺炎链球菌下呼吸道感染患者的临床情况及对抗生素的敏感情况。

Objective : The clinical status of low respiratory tract infection sufferers who infect S.Pneumoniae and their sensitivities to the antibiotics was analysed in ten hospitals of Tianjin in recent three years .

肺炎链球菌所致下呼吸道感染的耐药性分析

Analysis of the drug resistance of Streptococcus pneumoniae induced lower respiratory infection

同时，侵袭性肺炎链球菌多重耐药情况严重，最多见的耐药模式为红霉素、复方新诺明、四环素的多重耐药，临床需慎用大环内酯药物作为治疗侵袭性肺炎链球菌感染的一线药物。

The multidrug resistance of invasive pneumococcal was severe . The main mode was erythromycin , trimethoprim-sulfamethoxazole and tetracycline multidrug resistance . Macrolides should be cautiously used to treat the infection of invasive pneumococcal .