缓释药物

难溶性药物洛伐他汀缓控释制剂的研究缓释药物纤维的发展

Studies on Sustained-Release and Controlled-Release Tablets of Insoluble Lovastatin Development of slow-release iatric fiber

缓释药物纤维的发展

Development of slow-release iatric fiber

三种典型的聚合物微球（E、F和H-MS）的体外药物释放表明石杉碱甲的释放没有显著的突释，可缓释药物5～6周。

In vitro drug release from the three kinds of microspheres revealed sustained release of the drug for about 5-6 weeks without significant burst release .

转速、压片压力及PDN的特性粘度对缓释药物的释放均有一定的影响。

The effects of rotate speed , compression force and the intrinsic viscosity of PDN were significant .

磁导向甲氨蝶呤缓释药物对口底癌HSC-2细胞生长和起微结构的影响

Effects of magnetic methotrexate conjugates on the proliferation and ultrastructure of HSC-2 cells

特别是缓释药物涂层支架（drug-ElutingStent），成为近几年研究的热点，在国外已经有可喜的成果传出。

Among the coatings the drug-eluting stent has been the spotlight in recent years . Big achievements have been made abroad , but there is no complete study on coating materials within our country .

目的：探讨磁导向甲氨蝶呤缓释药物（FM-MTX）对人口底癌HSC-2细胞生长及细胞超微结构的影响。

Objective : To investigate the effects of magnetic methotrexate conjugates ( FM MTX ) on the multiplication and ultrastructure of human oral floor carcinoma HSC 2 cells .

结论：5-FU-Ab-NPs保持原5-FU-NPs缓释药物的特点，具有双重活性功能，即免疫导向和缓释药物，有利于提高肿瘤局部药物浓度。

CONCLUSION : The 5-FU-Ab-NPs possess the similar delayed released activity to 5-FU-NPs and have double activity of immune targeting and delayed releasing , which may increase the local concentration of 5-FU .

多孔微晶玻璃作为缓释药物载体的体外实验研究

In vitro drug release behavior of carrier made of porous glass ceramics

甲壳素及其衍生物在缓释药物中的应用

Application of chitin and its derivates in sustained release drugs

研究了一种新型铁炭复合磁靶向缓释药物载体材料的制备方法。

Preparation of iron-carbon magnetic powder for delivering chemotherapeutic drug were described .

缓释药物载体明胶微球酸水解影响因素的研究

Study on influence factor of acid degradation of gelatin-microsphere used as drug carrier

总结了超临界抗溶剂技术在微粉化药物和制备缓释药物微球方面的研究现状和发展。

The present research situation and development of drug micronization and embedment is summarized .

缓释药物&患者的福音

Controlled Release Drugs ── Good Tidings for Patients

纤维蛋白胶载体复合骨形态发生蛋白和庆大霉素缓释药物治疗感染性骨缺损的实验研究

Experimental Study of Treatment of Infected Bone Defects with Bone Morphogenetic Protein and Gentamicin-loaded Fibrin Glue Drug Delivery System

结论普罗帕酮微囊具有显著平稳缓释药物作用，达到抗心律失常缓释长效的治疗目的。

CONCLUSION the microcapsule propafenone has the stable slow-released drug effect and reaches the standards of long-acting treatment for anti-arrhythmia .

本文简单介绍了可控释放技术在医疗和农业中的应用及其原理，并阐述了缓释药物美好的前景。

This article introduces the applications of controlled release techniques in medicine and agriculture , and expounds their bright prospects .

交联补强硅橡胶包埋18-甲基炔诺酮的释放行为多孔微晶玻璃作为缓释药物载体的体外实验研究

Drug Release System Based on Silicone Rubber and Levo-norgestrel IN VITRO DRUG RELEASE BEHAVIOR OF CARRIER MADE OF POROUS GLASS CERAMICS

文章介绍了缓释药物纤维的发展、开发技术、分类及药物纤维价值。

The development technology , applied types and value of the slow & release iatric fiber were introduced in the article .

脂质体由于具有高度安全性、生物相容性、广泛的载药性等特点，是极具研发前景的靶向、缓释药物载体。

Liposomes are promising drug targeting and controlled release systems , because of their good safety , biocompatibility and drug loading capability .

结论布洛芬聚乳酸微球在一定浓度下可以作为一种局部缓释药物应用于颅内。

Conclusion : The ibuprofen polylactide microspheres could be used as a local slow release drug in cranial under a certain concentration .

结论含液体石蜡的海藻酸钙小丸经包衣处理可以达到胃内漂浮和局部缓释药物的目的。

Conclusion Coating floating beads made by Alginate-Na and liquid paraffin can be considered as a gastro-floating formulation releasing drug consistently and locally .

证实采用常规给药方法血清药物浓度较高且持续时间短，包埋缓释药物血清浓度较低、持续时间较长。

The serum drug is higher and shorter time by the routine methods . The serum concentration of FT-207 is lower and retarded by implanted .

结论该缓释药物植片在兔眼玻璃体内药代学数据符合眼内炎抗菌药物治疗要求。

Conclusion This kind of sustained release drug implant piece , according to its pharmacokinetics data in rabbit vitreous , conforms to antibacterial medication demand of endophthalmitis .

纳米粒载体可以增加药物的口服吸收、靶向药物、控释或缓释药物、穿透生理屏障等，从而增加药物疗效，减轻药物副作用。

Nanoparticles carriers could be used to increase the availability of drug for oral uptake , targeted release drugs , controlled or sustained release drugs , across the physical barriers and so on .

方法选用环丙沙星、双氯芬酸钠作为抗菌、抗炎药物，甲壳素、卡波姆作为缓释药物的骨架材料，直接压片法制得药物缓释片，并应用于伤道局部，观察伤道组织的抑菌效果；

Metheds The tablet which contains ciprofloxacin and diclofenac sodium was made by direct mechanical compression , in which Chitin and Carbomer as framework material were used for constant release of the drugs .

指出了缓释药物纤维今后研究的方向为准确控制缓释药物纤维药量、高温纺丝过程中有效保护药物性能，纤维降解时避免药物突释等。

The development trend of slow-release iatric fiber s focuses on the accurate control of drug release of slow-release iatric fiber , the efficient protection of pharmacological effect during high-temperature spinning process and the avoidance of the initial burst of medicines during fiber degradation .

进行了家犬体内VPA缓释片药物动力学研究和生物等效性评价。

The pharmacokinetics study and bioequivalence evaluation of the VPA sustained-release tablet in dogs were made .

人工神经网络预测别嘌醇HPMC缓释片药物释放D-苯丙氨酸和别嘌醇是两种具有重要药用价值的化合物。

Using Artificial Neural Network ( ANN ) to quantitatively predict allopurinol release from HPMC sustained release tablets D-phenylalanine and Allopurinol have been widely applied in the pharmaceutical field .

释放分割法体外评价释放特征符合Higuchi方程的缓释制剂药物动力学

The Release-Division method : a novel in vitro pharmacokinetic evaluation method for the sustained release dosage forms with a release profile characterized by the Higuchi equation