稳态血药浓度

稳态血药浓度峰值和谷值与体重剂量呈正相关；

There is positive correlation between peak and trough steady-state concentration and the body weight doses .

目的：研究硫酸吗啡控释片（CRMS）和即刻释放片（IRMS）在中国癌痛患者中多次给药后的稳态血药浓度，其波动性及与临床疗效的相关性。

OBJECTVE : To study the steady state plasma concentration of two formulations of morphine sulphate in Chinese cancer patients after multiple doses and their relations with clinical analgesic effect .

应用Bayesian反馈法，预测21例高血压病人口服阿替洛尔的个体药动学参数及稳态血药浓度C（pss），并与经典药动学方法估算的结果比较。

Bayesian approach was applied for predicting the individual pharmacokinetic pa-rameters and stead-state blood concentration of atenolol after oral administration in 21 patients with hypertension .

方法对126例癫痫患儿使用丙戊酸钠达稳态血药浓度后，采用荧光偏振免疫法（FPIA）测定其血药浓度，并分析结果。

Methods The drug serum concentration in126 epileptic cases was determined fluorescence polarization immunoassay ( FPIA ) . The results had been analyzed .

治疗第8天，随机抽取试验组13例和对照组12例UC患者血清，应用高效液相色谱分析法检测血清5ASA及其代谢产物Ac5ASA的稳态血药浓度。

Thirteen patients in 5 ASA group and 12 patients in SASP group were randomly picked out after 8 days of treatment to determine their serum concentration of 5 ASA by high performance liquid chromatographic assay .

使用高效液相色谱-荧光检测法（HPLC-FLD）测定高血压患者的稳态血药浓度，使用水银血压计测量治疗前、后高血压患者的血压值。

The plasma concentrations of telmisartan were determined by high performance liquid chromatograpy - Fluorescence detector ( HPLC-FLD ) . The blood pressures of the patients were measured before and after treatment .

女性的稳态血药浓度显著高于男性患者。

Stable plasma concentration of clozapine in female patients was statistically higher than that in male ones .

目的··：研究正常人单剂量口服北京产硫酸吗啡控释片的人体相对生物利用度，及多次给药的稳态血药浓度和波动性。

Objective : To study the pharmacokinetics and relative bioavailability of domestic controlled release morphine sulphate tablet .

结论：推荐单用氯氮平治疗精神分裂症的稳态血药浓度为400ug/L左右。

Conclusions : Stable blood concentration around 400u g / 1 is recommended for single dose of Clozapine for treatment schizophrenia .

目的研究氯氮平不同剂量时稳态血药浓度与临床效应的关系。

Objective The study investigated the relationship between serum level and clinical response to clozapine in different dose for treating schizophrenic patients .

结论多次服用缓释片的稳态血药浓度高于普通片的稳态血药浓度，原因在于缓释片可持续释放、持续吸收，从而保持血浆中较高的浓度。

CONCLUSION The higher levels of total coenzyme Q10 following the administration of sustained release tablets may be related to the slow release and continuous absorption .

结果：稳态血药浓度与给药剂量、给药时间、是否联合用药等有着密切的关系。

Results : There is a close relation between the drug serum concentration in stable state and the administration dosage , interval and weather associated with other epileptic drugs .