磷酸二酯酶抑制剂

己酮可可碱（pentoxifylline，PTX）是一种非选择性磷酸二酯酶抑制剂，被广泛用于治疗血管性疾病。

Pentoxifylline ( PTX ), an unselective phosphodiesterase inhibitor , has been used widely to treat vascular disease .

目前营养和药物治疗包括低蛋白饮食并补充酮酸/氨基酸制剂，使用影响蛋白质/氨基酸代谢的药物生长激素、重组人促红细胞生成素和磷酸二酯酶抑制剂Pentoxifylline和Amrinone等。

Nutritional and drug treatment includes low protein diet plus amino acids / keto acids formulation and administration of growth hormone , recombinant human erythropoietin and phosphodiesterase inhibitor pentoxifylline and amrinone .

传统的正性肌力药物&儿茶酚胺类、磷酸二酯酶抑制剂、洋地黄制剂均通过增加细胞内cAMP和Ca2+浓度来提高心肌收缩力。

Common positive inotropic drugs & catecholamines , phosphodiesterase - ⅲ inhibitors and digoxin increased intracellular cAMP of Ca 2 + to enhance the contractility of myocardium .

磷酸二酯酶抑制剂Rolipram对NOD小鼠免疫应答的影响

The role of Rolipram in immune response in NOD mice

目前，较为确定的SIR治疗药物有：类固醇类药物、乌司他丁、肝素和其他葡萄糖胺聚糖、磷酸二酯酶抑制剂如米力农和氨力农、抗氧化剂以及硝普钠等。

At present , the more determined drugs consist of steroid drugs , Ulinastatin , heparin and other glucosamine glycan , phosphodiesterase inhibitors such as Milrinone and Amrinone , anti-oxidants , and Sodium Nitroprusside and so on .

目的为探讨磷酸二酯酶抑制剂在慢性粒细胞白血病细胞系增殖与凋亡中的作用，研究了非选择性磷酸二酯酶抑制剂氨茶碱对K562细胞系的影响。

Objective To investigate whether and how phosphodiesterase ( PDE ) inhibitors modulate the proliferation , cell cycle and apoptosis in K562 cells . The effects of aminophylline ( AM ), a non-specific PDE inhibitor on K562 cells were explored .

磷酸二酯酶抑制剂吡唑并[4,3-d]嘧啶-7-酮类衍生物的研究

Studies of phosphodiesterase inhibitors pyrazolo [ 4,3-d ] pyrimidin-7-one derivatives

磷酸二酯酶抑制剂的药理及临床应用进展

Pharmacology and application progress of the phosphodiesterase inhibitor

选择性磷酸二酯酶抑制剂研究进展

Progress in selective inhibitors of cyclic nucleotide phosphodiesterase

我也使用磷酸二酯酶抑制剂如巡能泰或己酮可可碱进行治疗。

I also use a medicine called Trental or Pentoxifylline as a phosphodiesterase inhibitor .

磷酸二酯酶抑制剂使用率为8.8%。

Phosphodiesterase inhibitor was used in 8.8 % .

磷酸二酯酶抑制剂与学习记忆相关信号转导通路研究进展

Progress in the relationship of phosphodiesterases inhibitors and signal transduction pathway associated with learning and memory

当前使用的正性肌力药仍以洋地黄强心甙类和磷酸二酯酶抑制剂（米力农、氨力农）为主。

Currently used inotropic drug digitalis glycosides still and phosphodiesterase inhibitors ( milrinone , amrinone ) dominated .

查阅近年来国内有关磷酸二酯酶抑制剂的文献资料。

The authors have done the research by consulting the relative domestic phosphodiesterase inhibitor literature published in recent years .

目的：观察非特异性磷酸二酯酶抑制剂己酮可可碱对热暴露大鼠的保护作用。

AIM : To observe the protective effect of pentoxifylline , a nonspecific phosphodiesterase inhibitor , on rats in heat exposure .

强心甙长期用药易发生中毒，磷酸二酯酶抑制剂长期应用毒副作用较大，死亡率较高。

Cardiac glycoside drugs prone to long-term toxicity , long-term application of phosphodiesterase inhibitors drug side effects , a higher mortality rate .

背景与目的西洛他唑是一种Ⅲ型磷酸二酯酶抑制剂，具有抗血小板聚集、抗血栓等作用。

BACKGROUND OBJECTIVE Cilostazol , a phosphodiesterase type ⅲ inhibitor , plays a role in inhibition of platelet aggregation , thrombosis and so on .

治疗急性心力衰竭的传统药物，如：利尿剂、血管扩张剂、肾上腺素能受体激动剂、磷酸二酯酶抑制剂等不仅作用单一，而且各有其局限性。

The conventional treatments for acute heart failure , such as diuretics , vasodilators , catecholamines , phosphodiesterase inhibitors , are not only single action treatments , but also limited .

磷酸二酯酶V抑制剂对肺循环血流增多大鼠模型离体肺动脉环的舒张作用

Effects of phosphodiesterase 5 inhibitor on the impaired relaxation of ex vivo pulmonic ring of rats with increased pulmonary blood flow

伐地那非是一种高选择性的新型磷酸二酯酶5抑制剂，是广泛ED人群的一线治疗药物。

Vardenafil , a novel and highly selective phosphodiesterase 5 inhibitor , is the first line therapy for the broad ED population .

另有报道指出，磷酸二酯酶-5抑制剂西地那非（sildenafil，伟哥）通过增加cGMP的积聚激活PKG，进而保护缺血／再灌注的心肌细胞。

It has also been reported that inhibition of phosphodiesterase-5 with sildenafil ( Viagra ) which can augment cGMP accumulation protects cardiomyocytes from ischemia / reperfusion injury via a PKG-dependent mechanism .

目的：评价磷酸二酯酶5抑制剂的进展与临床合理应用。

OBJECTIVE : To evaluate the research progress and clinical application of PGE5 inhibitor .

他达那非是一种口服的新型磷酸二酯酶5抑制剂，主要治疗男性勃起功能障碍。

Tadalafil is an oral selective PDE5 inhibitor indicated for the treatment of erection dysfunction .

磷酸二酯酶5抑制剂的研究进展

Advances in Type 5 Phosphodiesterase Inhibitors

目的：磷酸二酯酶Ⅲ抑制剂在治疗慢性充血性心力衰竭方面的研究近年内已成为热点。

Objective : The researches of phosphodiesterase ⅲ inhibitor for curing chronic congestive heart failure have been a focus point .

碱性磷酸酶&孔雀绿定磷法筛选磷酸二酯酶4抑制剂硝酸盐还原酶一步法测定血清中硝酸盐浓度

Screening of Cyclic Nucleotide Phosphodiesterase 4 Inhibitors via Malachite Green Assay of Inorganic Phosphate Released by Calf Intestinal Alkaline Phosphatase Determination of Serum Nitrate Concentration by Nitrate Reductase One Step Method

磷酸二酯酶亚型抑制剂与细胞周期蛋白抑制剂对绵羊卵母细胞体外成熟的影响蛋白磷酸酶1对HIV-1转录的调节作用及其抑制剂研究

Effect of the inhibitor of cdk and specific phosphodiesterase isoenzyme inhibitors on ovine oocytes meiotic maturation in vitro Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors

孔雀绿&磷钼杂多酸法测定磷酸二酯酶活性及其抑制剂的影响

Malachite Green-Phosphomolybdic Heteropoly Acid Determination of Phosphodiesterase Activity and the Impact of Inhibitors

磷酸二酯酶9及其抑制剂的研究进展

Research progress on phosphodiesterase 9 and its inhibitors

选择性磷酸二酯酶同功酶抑制剂与支气管哮喘的治疗

Isoenzyme-selective phosphodiesterase inhibitors and treatment of bronchial asthma