硬下疳

目的探讨硬下疳的误诊情况和误诊因素。

Objective To explore misdiagnosis of hard chancre and its contributing factors .

梅毒硬下疳组织超微结构研究

The Investigation of the Ultrastructure of Syphilitic Chancre

梅毒硬下疳实验室检查策略初探

Primary Strategy of Study on Laboratory Methods for the Diagnosis of Primary Syphilis with Chancre

方法在透射电镜下观察梅毒硬下疳组织细胞超微病理变化。

Methods The ultrastructural pathological changes of syphilitic chancre were examined with transmission electron microscopy .

结果I期梅毒皮疹以硬下疳为主，Ⅱ期梅毒皮疹复杂。

Results Phase I syphilis manifests hard chancre . Phase II syphilis manifests rash which are complicated .

结果162例硬下疳患者中，48例曾发生误诊，误诊率为296%。

Results In these 162 cases of hard chancre , misdiagnosis occurred to 48 cases , accounting for 29.6 % .

早期梅毒的重要特征是感染梅毒螺旋体两周后在原始部位形成硬下疳。

The primary stage of syphilis is evident a couple of weeks after initial infection as a chancre at the site of inoculation .

结论病理检查对硬下疳、扁平湿疣、鳞屑性丘疹皮疹诊断有一定意义，而斑疹呈非特异性炎症改变。

Conclusion The histopathology is of great significance in the diagnosis of primary syphilis , condyloma datum and papulosquamous syphilide , but of limitid value for macular syphilide .

结论硬下疳和二期梅毒基本病理改变为梅毒性亚急性炎症，结节型三期梅毒为上皮样细胞肉芽肿。

Conclusion The fundamental pathologic changes of hard chancre and secondary syphilis are a subacute inflamation caused by pallidula spirochaeta , and those of nodular tertiary syphilis epithelioid cell granuloma .

硬下疳病变中央部表皮缺损，真皮中上部或全层显示弥漫性混合性炎细胞浸润和明显血管内膜炎。

Hard chancre showed that epidermis might be absent in the center of the disease focuses and a diffuse mixed inflammatory infiltration was present at upper and middle dermis or the whole dermis as well as the endoangiitis in the dermis .