皮肤给药

新型的皮肤给药系统&脂质体

A New Topical and Transdermal Drug Delivery System & Liposomes

目的采用RPHPLC测定盐酸青藤碱灌胃和皮肤给药后不同时间大鼠体内血清浓度，计算出灌胃和皮肤给药途径主要药动学参数。

OBJECTIVE A RP-HPLC assay was developed to determine the concentration of sinomenine HCl in serum and its pharmacokinetics was studied in rats after ig and skin administration .

为根除我国牛皮蝇蛆病，试验了一种经皮肤给药透皮吸收的新药剂&点涂剂。

To eradicate bovine hypodermosis disease Fenthion spot-on as a new medicine absorbed percutaneously was tested and exploited .

目的研究格列美脲凝胶骨架控释贴剂的药剂学性质及其经大鼠皮肤给药的药代动力学和相对于口服水溶液的生物利用度。

Aim To study the pharmaceutical characterization , the pharmacokinetics and relative bioavailability of glimepiride gel-matrix controlled-release patch in rats .

研究发现脂质体作为新型的皮肤给药载体系统，与皮肤的角质层在组成和结构上具有高度的相似性，可以与角质层发生融合，增加药物在皮肤局部的积累，起到缓释作用；

The observations indicate as new-type vehicle , liposome is simular in the composition and structure to the stratum corneum lipids .

结果：家兔阴道和眼局部用药以及豚鼠皮肤给药和生理盐水对照组比较无明显差异。

Results : There is no significant difference between tested groups in stimulation and hypersensitivity compared with those of the NS group .

目的：观察和测定蜀羊泉凝胶长期连续经皮肤给药对实验动物大鼠的长期毒性。

Objective : To observe the long-term toxicity of rats which we had applied Solanum lyratum Thunb gel on their skins daily for90 days .

结论：结果表明，合理配制的中药复方制剂可以经皮肤给药，其有效成分能透皮吸收进入体内。

Conclusion : The results indicate that the main effective ingredients of ⅱ Recipe of Eliminating Effusion Ointment can be absorbed through mice ' skin .

研究了环孢素柔性脂质体经小鼠皮肤给药的药动学行为，并与用新山地明小鼠灌胃给药进行了比较。

The study was to investigate the pharmacokinetic behaviors of cyclosporin A in mice by transdermal delivery of flexible liposomes and oral administration of the marketed preparation .

目的：通过动物皮肤给药安全性实验，研究退黄外洗液的安全性，为临床用药提供参考依据。

OBJECTIVE : To study the safety of Jaundice-abating Chinese Herbal Lotion for External use through animal skin susceptibility test so as to provide references for its clinical application .

目的：通过家兔及豚鼠的皮肤给药急性毒性试验、皮肤刺激性试验及皮肤过敏性试验，以证实寒立消贴敷剂的安全性，也为进一步开发利用该药打下基础。

Purpose : To testify the safety of Han Li Xiao as well as its further development and utilization , the experiments of acute toxicity , skin irritation and the skin allergy were performed on rabbit and guinea pig by dermic administration . Methods : 1 .

本文利用脂质体包封FP进行皮肤局部给药，既有效地将FP渗透进入局部深层组织，同时又避免了较高的血药浓度，这对于减少FP副作用，增加疗效都有着很大的意义。

Therefore , liposome was selected to carry FP into local deeper tissues and avoid high plasma concentration . It is important to minimize the side effects of oral FP and increase curative effect .

脂质体作为皮肤局部给药载体的研究进展

The progresses of liposomes as carrier for dermal topical administration

目的：研究茶碱微乳在家兔不同皮肤部位给药后的经皮吸收及药代动力学。

Aim : To investigate the transdermal absorption and pharmacokinetics of theophylline microemulsions on the acupuncture points of rabbits .

结果脂质体作为皮肤局部给药的载体具有许多优点，但作用机制不一，影响因素很多，新型脂质体的研究使脂质体皮肤给药的前景更为广阔。

RESULTS The liposomes have many virtues as a carrier for dermal topical application and have various machanisms and influence factors . The study of novel liposomes brings a broad prospect for dermal application .

方法以大量有代表性的文献进行分析、归纳，阐述了脂质体作为皮肤局部给药载体的特点、机制、处方设计、实验研究及新型脂质体的研究。

METHOD A lot of typical literatures were cited to analyse and summarize , and the characters , mechanism , formulation design , experimental studies and novel liposomal substitutes of liposomes as a carrier for dermal topical application were presented .

用自制药膏高倍剂量涂布脱毛后的家兔皮肤，观察多次给药（每天3次，每次10g，连续7d）后对完整皮肤及受损皮肤的刺激性反应。

To daub this antiphlogistin on naked skin of rabbits with high dosage and 3 times a day , 10g each time for 7d continuously , the stimulation reaction of the antiphlogistin to healthy skin and damaged skin were observed .

近年来，以胰岛素为代表的多肽蛋白类药物的透皮给药和皮肤疾病治疗药物的皮肤靶向给药是经皮给药系统研究中的两个热点问题。

Much attention has been paid on transdermal delivery , topical delivery and dermal delivery in TDDS . The transdermal delivery of peptides and proteins with large molecular weights and skin targeting delivery of drugs for the therapy of skin diseases are attractive challenges in TDDS .

结论醇质体能显著促进脂溶性药物非那甾胺的经皮渗透，增加药物在皮肤中的蓄积，有望成为一类新型的皮肤给药制剂。

CONCLUSION Ethosomes can improve the transdermal permeation and skin accumulation of finasteride .

研制的EMP霜透皮吸收效果好，且对皮肤无刺激性和致敏性，适宜于皮肤外用给药。

The study prepared EMP cream ( O / W ) and explored its percutaneous penetration in vitro and irritation on skin .