梓醇

HPLC法测定百合固金丸中梓醇的含量

Determination of Catalpol in Baihe Gujin Pills With HPLC Method

HPLC测定生地黄浓缩颗粒中梓醇的含量

Determination of Catalpol in Radix Rehmanniae enriched grain by HPLC

HPLC法测定地黄不同炮制品中梓醇的含量

Determination of catalpol in different processed products of Radix rehmanniae by HPLC

HPLC测定大鼠脑脊液中梓醇的含量

HPLC determination of catalpol in cerebrospinal fluid of rats

基于DFT的梓醇核磁共振谱的理论研究

Theoretical Study on NMR Spectrum of Catalpol by DFT

地黄活性成分梓醇对转基因CHO细胞M2受体的调节作用

Regulatory effect of catalpol from Radix Rehmanniae on M_2 receptor density in M_2 receptor transfected CHO cells

这些结果表明了在LPS介导的炎症损伤时，梓醇可以有效的抑制小胶质细胞的活化及炎症因子的产生，从而起到神经保护作用。

The results indicated that catalpol could effectively attenuated LPS-induced microglial activation , inhibited the production of inflammatory factors and subsequently protected the dopaminergic neurons .

梓醇可明显改善细胞形态结构，显著降低LDH释放量、降低P53蛋白的表达，提高Bcl-2蛋白的表达，降低细胞凋亡率。

Catalpol could improve the morphology of cells . It could increase bcl-2 protein expression , decrease P53 protein expression and the release of LDH , and reduce apoptotic rate .

接着观察了梓醇对血清饥饿、丙二酸钠损伤的PC12细胞增殖的影响。

Then we observed the effects of catalpol on proliferation in serum-starved and sodium malonate-intoxicated PC 12 cells .

结果显示梓醇可提高小鼠脾重指数，增加GSH、SOD和GSH-PX活力，降低GST活力和MDA含量。

The results proved that catalpol significantly elevated the splenic weights , increased the levels of GSH , GSH-PX and SOD , decreased GST activity and MDA level of mice .

以上研究结果表明，梓醇可抑制LPS及MPP~+引起的多巴胺能神经元的损伤，并且具有抗炎作用和抗氧化作用。

These-results suggest that catalpol may have the capacity to counteract the toxicity of MPP ~ + by attenuating change of the mitochondrial membrane permeability that is associated with oxidative stress damage .

结论：HPLC测定中药生地黄浓缩颗粒中梓醇含量方法简便，结果准确。目的：建立测定中药生地黄浓缩颗粒中有效成分梓醇含量的HPLC方法。

Conclusion : The method is constant and have a good concentration . It is good method for determination of catalpol in radix rehmanniae enriched grain . Objective : The catalpol in radix rehmanniae was determination by HPLC .

借助于高效液相考察梓醇对PD小鼠脑组织多巴胺（DA）及其代谢物（DOPAC）含量的影响，发现梓醇治疗10天能提高中脑、纹状体内多巴胺及其代谢物的含量。

Catalpol ( 10 mg / kg for 10 days ) improved the cognition of mice , increased the content of dopamine and DOPAC in mice midbrain and striatum .

本研究中，利用MPTP分别处理中脑神经元-星形胶质细胞混合培养体系，以进一步探索梓醇的神经保护作用及其潜在的保护机制。

In this study , we treated mesencephalic neuron-astrocyte with MPTP respectively to investigate the neuroprotective effects of catalpol and the underlying protective mechanisms .

首先，观察了梓醇对KM小鼠免疫器官指数、ConA刺激的脾淋巴细胞增殖反应、混合淋巴细胞反应、Balb／c小鼠异体移植皮片存活时间的影响。

Firstly , the effects of catalpol on the thymus index and spleen index in KM mice , the splenocyte proliferation stimulated by ConA , mixed lymphocyte reaction , survival time of allografts in Balb / c mice were investigated .

地黄属资源植物中梓醇的分布及积累动态

Distribution and Accumulation Trends of Catalpol in Resource Species of Rehmannia

梓醇对α葡萄糖苷酶活性及醛糖还原酶活性无抑制作用；

Catalpol has no inhibition effect of a-glucosidase and aldose reductase .

结论梓醇对缺血再灌注受损神经元有保护作用。

[ Conclusion ] Catalpol was of the effect of neuro protection .

地黄中梓醇的提取鉴定及其急性毒性试验

Separation and Identification of Catalpol from Rehmannia and its Acute Toxicity Test

液相层析法分离制备地黄活性成分梓醇

Separation and Preparation of Active Component of Radix Rehmanniae Catalpol by HPLC

毛细管区带电泳法测定地黄中梓醇的含量

Determination of Catalpol in Radix Rehmanniae by Capillary Zone Electrophoresis

结果：壳聚糖澄清法可较好地保存降糖通脉君药地黄中有效成分梓醇的含量。

Results : Catalpol can be well preserved by chitosan clarification method .

梓醇在帕金森病模型中保护作用的研究

Studies on Protective Effects of Catalpol in Models for Parkinson 's Disease

我们尝试了对地黄叶中的梓醇进行了开发利用。

We tried to utilize the catalpol in the leaves .

地黄梓醇脑保护的药理作用及机制研究进展

Progress in studies of pharmacological action and mechanisms of catalpol on brain diease

鲜地黄根梓醇含量与外形的相关性

Correlation between the content of catalpol and the appearance of the fresh Radix Rehmanniae

鲜地黄和生地黄的不同部位梓醇含量和可溶性糖的含量也不同。

The contents of catalpol and sugars were different between fresh earthnuts and processed earthnuts .

梓醇的制备方法。

The method for catalpol preparation .

结果梓醇与其他峰均能达到基线分离，其色谱峰形好。

RESULTS Catalpol and other peaks are separated well and the peak shape was presented well .

首先，本文采用高效液相色谱法测定不同发育时期的鲜地黄叶与块根中梓醇的含量，对地黄叶中梓醇的积累分布规律进行了探索。

At different developmental stages by HPLC , explored distribution and accumulation regularity of catalpol in leaves .